Serological response to avian influenza viruses among occupationally exposed population in Taiwan, a longitudinal cohort study, 2021–2023
The Taiwan Centers for Disease Control (TCDC) initiated longitudinal sero-epidemiological surveillance of avian influenza viruses (AIVs) targeting poultry workers exposed on affected farms since 2021. Convalescent-phase serum samples were collected from these workers 21–28 days post-outbreak identif...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Journal of the Formosan Medical Association |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S092966462400576X |
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| author | Tsung-Pei Tsou Chieh-Yu Lin Shu-Er Yang Hui-Tzu Wang I-Ling Yu Ming-Tsan Liu Yi-Chien Chih |
| author_facet | Tsung-Pei Tsou Chieh-Yu Lin Shu-Er Yang Hui-Tzu Wang I-Ling Yu Ming-Tsan Liu Yi-Chien Chih |
| author_sort | Tsung-Pei Tsou |
| collection | DOAJ |
| description | The Taiwan Centers for Disease Control (TCDC) initiated longitudinal sero-epidemiological surveillance of avian influenza viruses (AIVs) targeting poultry workers exposed on affected farms since 2021. Convalescent-phase serum samples were collected from these workers 21–28 days post-outbreak identification. TCDC recontacted participants in subsequent years for repeat serological sampling. Hemagglutination inhibition (HI) assays were used to test against representative strains of AIV A/H5 2.3.4.4c and A/H5 2.3.4.4b. By the end of 2023, a 2-year cohort of 59 participants and a 3-year cohort of 61 participants were established. None of them had laboratory-confirmed infection. HI titers against AIV A/H5 2.3.4.4c remained low from 2021 to 2023. For AIV A/H5 2.3.4.4b, HI titer remained low from 2021 to 2022 but increased in more than half of the participants (60%, 72/120) in 2023. This change parallels the increasing AIV A/H5 2.3.4.4b burden indicated by increased outbreaks and warrants continuous monitoring. |
| format | Article |
| id | doaj-art-e83345e90e044e719a8c9bacb5d782a0 |
| institution | OA Journals |
| issn | 0929-6646 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of the Formosan Medical Association |
| spelling | doaj-art-e83345e90e044e719a8c9bacb5d782a02025-08-20T02:37:41ZengElsevierJournal of the Formosan Medical Association0929-66462025-06-01124657858110.1016/j.jfma.2024.12.017Serological response to avian influenza viruses among occupationally exposed population in Taiwan, a longitudinal cohort study, 2021–2023Tsung-Pei Tsou0Chieh-Yu Lin1Shu-Er Yang2Hui-Tzu Wang3I-Ling Yu4Ming-Tsan Liu5Yi-Chien Chih6Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan, ROCCenters for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan, ROCCenters for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan, ROCCenters for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan, ROCCenters for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan, ROCCenters for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan, ROCCorresponding author. Division of Preparedness and Emerging Infectious Diseases, No. 6, Linsen South Road, Jhongjheng District, Taipei, 10050, Taiwan, ROC.; Centers for Disease Control, Ministry of Health and Welfare, Taipei, Taiwan, ROCThe Taiwan Centers for Disease Control (TCDC) initiated longitudinal sero-epidemiological surveillance of avian influenza viruses (AIVs) targeting poultry workers exposed on affected farms since 2021. Convalescent-phase serum samples were collected from these workers 21–28 days post-outbreak identification. TCDC recontacted participants in subsequent years for repeat serological sampling. Hemagglutination inhibition (HI) assays were used to test against representative strains of AIV A/H5 2.3.4.4c and A/H5 2.3.4.4b. By the end of 2023, a 2-year cohort of 59 participants and a 3-year cohort of 61 participants were established. None of them had laboratory-confirmed infection. HI titers against AIV A/H5 2.3.4.4c remained low from 2021 to 2023. For AIV A/H5 2.3.4.4b, HI titer remained low from 2021 to 2022 but increased in more than half of the participants (60%, 72/120) in 2023. This change parallels the increasing AIV A/H5 2.3.4.4b burden indicated by increased outbreaks and warrants continuous monitoring.http://www.sciencedirect.com/science/article/pii/S092966462400576XInfluenza A virusHumanInfluenzaAvianSeroprevalence |
| spellingShingle | Tsung-Pei Tsou Chieh-Yu Lin Shu-Er Yang Hui-Tzu Wang I-Ling Yu Ming-Tsan Liu Yi-Chien Chih Serological response to avian influenza viruses among occupationally exposed population in Taiwan, a longitudinal cohort study, 2021–2023 Journal of the Formosan Medical Association Influenza A virus Human Influenza Avian Seroprevalence |
| title | Serological response to avian influenza viruses among occupationally exposed population in Taiwan, a longitudinal cohort study, 2021–2023 |
| title_full | Serological response to avian influenza viruses among occupationally exposed population in Taiwan, a longitudinal cohort study, 2021–2023 |
| title_fullStr | Serological response to avian influenza viruses among occupationally exposed population in Taiwan, a longitudinal cohort study, 2021–2023 |
| title_full_unstemmed | Serological response to avian influenza viruses among occupationally exposed population in Taiwan, a longitudinal cohort study, 2021–2023 |
| title_short | Serological response to avian influenza viruses among occupationally exposed population in Taiwan, a longitudinal cohort study, 2021–2023 |
| title_sort | serological response to avian influenza viruses among occupationally exposed population in taiwan a longitudinal cohort study 2021 2023 |
| topic | Influenza A virus Human Influenza Avian Seroprevalence |
| url | http://www.sciencedirect.com/science/article/pii/S092966462400576X |
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