Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective study
Purpose Early prediction of the prognosis of viral-related cirrhosis patients after transjugular intrahepatic portosystemic shunt (TIPS) is beneficial for clinical decision-making. The aim of this study is to explore a comprehensive prognostic assessment model for evaluating the survival outcomes of...
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Taylor & Francis Group
2025-12-01
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| Series: | Annals of Medicine |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2025.2484460 |
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| author | Sai Li Yong Li Chunhui Zhou Haiping Li Yazhuo Zhao Xiaoping Yi Changyong Chen Changli Peng Tianming Wang Fei Liu Juxiong Xiao Liangrong Shi |
| author_facet | Sai Li Yong Li Chunhui Zhou Haiping Li Yazhuo Zhao Xiaoping Yi Changyong Chen Changli Peng Tianming Wang Fei Liu Juxiong Xiao Liangrong Shi |
| author_sort | Sai Li |
| collection | DOAJ |
| description | Purpose Early prediction of the prognosis of viral-related cirrhosis patients after transjugular intrahepatic portosystemic shunt (TIPS) is beneficial for clinical decision-making. The aim of this study is to explore a comprehensive prognostic assessment model for evaluating the survival outcomes of patients post-TIPS.Materials and methods A total of 155 patients treated with TIPS were included in the study. The data were collected from electronic records. The nutritional status of the patient is evaluated using imaging examinations measuring by the axial CT images from the L3 vertebral level. The primary endpoint was set as death within 1 year after TIPS. Multivariate Cox regression was performed to determine the factors associated with mortality.Results The Cox regression analysis revealed that the lower PMFI was associated with a lower risk of all-cause mortality after TIPS (hazard ratio [HR] 1.159, 95% confidence interval [CI] 1.063–1.263, p = 0.001). Furthermore, subgroup analyses according to gender revealed the PMFI was associated with postoperative death both in male (HR 2.125, 95% CI, 1.147–3.936, p = 0.017) and female patients (HR 1.070, 95% CI, 1.001–1.144, p = 0.047). The area under the curve (AUC) for predicting death within 1 year was 0.807. The clinical impact curve analysis showed that PMFI had higher levels of risk threshold probability and a smaller gap between actual and predicted curves.Conclusions In viral-related cirrhosis patients with portal hypertension, increased muscle fat content might be a potential prognostic marker and associated with postoperative death after TIPS. |
| format | Article |
| id | doaj-art-e82efa2facee4255a40dd496aea1fc0a |
| institution | DOAJ |
| issn | 0785-3890 1365-2060 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj-art-e82efa2facee4255a40dd496aea1fc0a2025-08-20T03:08:23ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602025-12-0157110.1080/07853890.2025.2484460Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective studySai Li0Yong Li1Chunhui Zhou2Haiping Li3Yazhuo Zhao4Xiaoping Yi5Changyong Chen6Changli Peng7Tianming Wang8Fei Liu9Juxiong Xiao10Liangrong Shi11Interventional Radiology Center, Department of Radiology, The Third Xiangya Hospital of Central South Hospital, Changsha, Hunan, ChinaDepartment of Gastroenterology, Xiangya Hospital, Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaInterventional Radiology Center, Department of Radiology, Xiangya Hospital Central South University, Changsha, Hunan, ChinaPurpose Early prediction of the prognosis of viral-related cirrhosis patients after transjugular intrahepatic portosystemic shunt (TIPS) is beneficial for clinical decision-making. The aim of this study is to explore a comprehensive prognostic assessment model for evaluating the survival outcomes of patients post-TIPS.Materials and methods A total of 155 patients treated with TIPS were included in the study. The data were collected from electronic records. The nutritional status of the patient is evaluated using imaging examinations measuring by the axial CT images from the L3 vertebral level. The primary endpoint was set as death within 1 year after TIPS. Multivariate Cox regression was performed to determine the factors associated with mortality.Results The Cox regression analysis revealed that the lower PMFI was associated with a lower risk of all-cause mortality after TIPS (hazard ratio [HR] 1.159, 95% confidence interval [CI] 1.063–1.263, p = 0.001). Furthermore, subgroup analyses according to gender revealed the PMFI was associated with postoperative death both in male (HR 2.125, 95% CI, 1.147–3.936, p = 0.017) and female patients (HR 1.070, 95% CI, 1.001–1.144, p = 0.047). The area under the curve (AUC) for predicting death within 1 year was 0.807. The clinical impact curve analysis showed that PMFI had higher levels of risk threshold probability and a smaller gap between actual and predicted curves.Conclusions In viral-related cirrhosis patients with portal hypertension, increased muscle fat content might be a potential prognostic marker and associated with postoperative death after TIPS.https://www.tandfonline.com/doi/10.1080/07853890.2025.2484460Muscle fat contentcirrhosistransjugular intrahepatic portosystemic shuntpostoperative survival |
| spellingShingle | Sai Li Yong Li Chunhui Zhou Haiping Li Yazhuo Zhao Xiaoping Yi Changyong Chen Changli Peng Tianming Wang Fei Liu Juxiong Xiao Liangrong Shi Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective study Annals of Medicine Muscle fat content cirrhosis transjugular intrahepatic portosystemic shunt postoperative survival |
| title | Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective study |
| title_full | Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective study |
| title_fullStr | Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective study |
| title_full_unstemmed | Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective study |
| title_short | Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective study |
| title_sort | muscle fat content correlates with postoperative survival of viral related cirrhosis patients after the tips a retrospective study |
| topic | Muscle fat content cirrhosis transjugular intrahepatic portosystemic shunt postoperative survival |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2025.2484460 |
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