Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder

Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder

<b>Methods</b>: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder. <b>Results</b>: Processing parameters, specifically granulation temperature and screw speed,...

Full description

Saved in:

Bibliographic Details
Main Authors:	Zoltán Márk Horváth, Kirils Kukuls, Alīna Jaroslava Frolova, Marta Žogota, Elżbieta Maria Buczkowska, Līga Pētersone, Valentyn Mohylyuk
Format:	Article
Language:	English
Published:	MDPI AG 2025-05-01
Series:	Pharmaceutics
Subjects:	granulation melt granulation twin-screw melt granulation effervescent granules effervescent tablets sorbitol
Online Access:	https://www.mdpi.com/1999-4923/17/5/676
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Development of Effervescent Granules with Solid Dispersion of Furazolidone
by: A. O. Elagina, et al.
Published: (2022-02-01)

Development of standardized green coffee bean extract (Coffea canephora) into effervescent granules as an antioxidant supplement
by: Andre Wijaya, et al.
Published: (2024-11-01)

Development of Technology and Composition of the Medicinal Product for Oral Cavity Based on Phytosubstances
by: O. N. Abrosimova, et al.
Published: (2021-12-01)

The effect of processing mode on the characteristics of crystalline sorbitol powder
by: YU Shankai, et al.
Published: (2024-08-01)

Comparison of synthetic and natural binders supporting formation of granulated activated carbon
by: Skoczko Iwona, et al.
Published: (2025-04-01)

Feasibility of Hot Melt Extrusion in Converting Water-Based Nanosuspensions into Solid Dosage Forms
by: Erasmo Ragucci, et al.
Published: (2025-05-01)

Scaling of the Granulation Process in the Conditions of GMP Training Center and Assessment of Possible Risks
by: O. N. Abrosimova, et al.
Published: (2021-08-01)

Twin Screw Melt Granulation of Simvastatin: Drug Solubility and Dissolution Rate Enhancement Using Polymer Blends
by: Rasha M. Elkanayati, et al.
Published: (2024-12-01)

VITAMIN C AND CRANBERRY EXTRACT EFFERVESCENT TABLET FORMULATION, CHARACTERIZATION, AND EVALUATION
by: Haider Ali Gillani, et al.
Published: (2023-03-01)

Mathematical Model of Whey-Based Granulation Dispersed Mixtures Process in Disk-Type Devices
by: Maytakov Anatolij L.
Published: (2020-10-01)

Changes in the granulometric composition of a product overgranulated by balling with the use of "fattening" technology
by: Yu. A. Taran, et al.
Published: (2014-06-01)

Immature morphology of adult-born granule cells alters responsiveness and excitability in a multi-compartmental conductance-based model
by: Bahar Sert, et al.
Published: (2025-07-01)

The Effect of Disaccharide Concentration in a Liquid Binder on The Mechanisms and Kinetics of Disc Granulation
by: Obraniak Andrzej, et al.
Published: (2017-06-01)

GRANULATION OF POWDER MATERIALS WHEN USING «FATTENING» TECHNOLOGY
by: R. V. Morozov, et al.
Published: (2013-08-01)

Granulation and Convectional Driving on Stellar Surfaces
by: Johannes Tschernitz, et al.
Published: (2025-01-01)

Inhibition and evasion of neutrophil microbicidal responses by Legionella longbeachae
by: Hannah E. Hanford, et al.
Published: (2025-02-01)

Review of Intoxication: An Ethnography of Effervescent Revelry by Sébastien Tutenges
by: Ian Goodwin
Published: (2024-12-01)

Comparison of granulated lactose properties produced by various wet granulation methods without the use of binders
by: A. E. Baldaev, et al.
Published: (2025-06-01)

Selection of disintegrants for wet granulation method of “Angiolin” tablets
by: I. A. Mazur, et al.
Published: (2016-10-01)

Transcriptomic analysis of intracellular RNA granules and small extracellular vesicles: Unmasking their overlap in a cell model of Huntington's disease
by: Deepti Kailash Nabariya, et al.
Published: (2025-06-01)

Memenin Granüler Hücreli Tümörü: Olgu Sunumu
by: Celalettin Vatansev, et al.
Published: (2013-01-01)

Experimental and Numerical Study to Enhance Granule Control and Quality Predictions in Pharmaceutical Granulations
by: Maroua Rouabah, et al.
Published: (2025-03-01)

Development and study of reactive hot-melt extruded granules based on interpolymer combinations of Eudragit® copolymers for indomethacin delivery
by: S. F. Nasibullin, et al.
Published: (2025-03-01)

In-Vitro Cholesterol Reduction Using Three Dosages of Chitosan from Mangrove Crab Shells (Scylla serrata) in Effervescent Granules Suspension
by: Erna Sri Novyanti, et al.
Published: (2025-03-01)

Collective Effervescence as Self-Organization and Enaction
by: Christian Kronsted
Published: (2025-05-01)

Formulation and Evaluation of Antioxidant Activity of Instant Granules from 70% Ethanol Extract of Single Black Garlic (Allium sativum L.)
by: Abdul Aziz Setiawan, et al.
Published: (2025-05-01)

Formulation and Evaluation of Antioxidant Activity of Instant Granules from 70% Ethanol Extract of Single Black Garlic (Allium sativum L.)
by: Abdul Aziz Setiawan, et al.
Published: (2025-05-01)

GEOMETRICAL APPROACH TO THE DATA MODELS DESIGN, BASED ON THE GRANULATION THEORY
by: S. A. Butenkov, et al.
Published: (2016-08-01)

Development of Celecoxib Granules for Manufacturing of Prolonged Release Celecoxib Capsules and Tablets
by: A. Alkhodri, et al.
Published: (2022-02-01)

MORPHOLOGICAL AND ANATOMICAL STUDY OF GRANULES WITH SEEDS EPIDERMIS OF PLANTAGO OVATA FORSSK
by: J. V. Daironas, et al.
Published: (2017-07-01)

Identification of Sago-Pulp Amylolytic Bacteria and Its Utilization for Granulated Fertilizer
by: Uswatun Hasanah, et al.
Published: (2021-06-01)

A method for estimating the polymer gel granule volume by an optical technique
by: M.G. Tokmachev
Published: (2023-12-01)

Energy saving schemes in the technologies of manufacturing products granulated by crystallization of melts drops
by: Y. A. Taran, et al.
Published: (2011-02-01)

Numerical investigation of the two-phase flow behavior inside the effervescent atomizer at high aeration ratios
by: Z. Alizadeh kaklar, et al.
Published: (2025-05-01)

Intelligent Systems Model For Selective Laser Melting (Slm) Additive Modeling Of The Damping Of Ti-6al-4v In Turbulent Flow During Powder Bed Melting In The Manufacturing Process
by: Rihab Rihab Belgada
Published: (2024-12-01)

Size matters: Anaerobic granules exhibit distinct ecological and physico-chemical gradients across biofilm size
by: Anna Trego, et al.
Published: (2025-05-01)

The Effect of Wetting on The Course of The Drum Granulation
by: Błaszczyk Michał, et al.
Published: (2017-06-01)

SUBSTANTIATION OF A RATIONAL METHOD FOR DRYING WHEAT GLUTEN GRANULES IN A FLUIDIZED BED AND INSTALLATION FOR ITS IMPLEMENTATION
by: A. A. Pokoptseva, et al.
Published: (2023-01-01)

Changes the state of secretory granules of the superficial epitheliocytes of the pyloric mucous membrane in the stomach of rats under the action of epichlorohydrin
by: A. S. Smirnov, et al.
Published: (2016-10-01)

Cholesterol-activated stress granules reduce the membrane localization of DRD2 and promote prolactinoma dopamine agonists resistance
by: Yuyang Peng, et al.
Published: (2025-04-01)