Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder

Effervescent Tablet Preparation by Twin-Screw Melt Granulation with Sorbitol as a Melt Binder

<b>Methods</b>: Effervescent granules containing citric acid and sodium bicarbonate were successfully prepared for the first time via TS-MG using a polyol (sorbitol) as a melt binder. <b>Results</b>: Processing parameters, specifically granulation temperature and screw speed,...

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Bibliographic Details
Main Authors: Zoltán Márk Horváth, Kirils Kukuls, Alīna Jaroslava Frolova, Marta Žogota, Elżbieta Maria Buczkowska, Līga Pētersone, Valentyn Mohylyuk
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceutics
Subjects:
granulation
melt granulation
twin-screw melt granulation
effervescent granules
effervescent tablets
sorbitol
Online Access:https://www.mdpi.com/1999-4923/17/5/676
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