Mathematical Modelling of the Inhibitory Role of Regulatory T Cells in Tumor Immune Response
The immune system against tumors acts through a complex dynamical process showing a dual role. On the one hand, the immune system can activate some immune cells to kill tumor cells (TCs), such as cytotoxic T lymphocytes (CTLs) and natural killer cells (NKs), but on the other hand, more evidence show...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Complexity |
| Online Access: | http://dx.doi.org/10.1155/2020/4834165 |
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| author | Zhongtao Yang Cuihong Yang Yueping Dong Yasuhiro Takeuchi |
| author_facet | Zhongtao Yang Cuihong Yang Yueping Dong Yasuhiro Takeuchi |
| author_sort | Zhongtao Yang |
| collection | DOAJ |
| description | The immune system against tumors acts through a complex dynamical process showing a dual role. On the one hand, the immune system can activate some immune cells to kill tumor cells (TCs), such as cytotoxic T lymphocytes (CTLs) and natural killer cells (NKs), but on the other hand, more evidence shows that some immune cells can help tumor escape, such as regulatory T cells (Tregs). In this paper, we propose a tumor immune interaction model based on Tregs-mediated tumor immune escape mechanism. When helper T cells’ (HTCs) stimulation rate by the presence of identified tumor antigens is below critical value, the coexistence (tumor and immune) equilibrium is always stable in its existence region. When HTCs stimulation rate is higher than the critical value, the inhibition rate of effector cells (ECs) by Tregs can destabilize the coexistence equilibrium and cause Hopf bifurcations and produce a limit cycle. This model shows that Tregs might play a crucial role in triggering the tumor immune escape. Furthermore, we introduce the adoptive cellular immunotherapy (ACI) and monoclonal antibody immunotherapy (MAI) as the treatment to boost the immune system to fight against tumors. The numerical results show that ACI can control TCs more, while MAI can delay the inhibitory effect of Tregs on ECs. The result also shows that the combination of both immunotherapies can control TCs and reduce the inhibitory effect of Tregs better than a single immunotherapy can control. |
| format | Article |
| id | doaj-art-e825cc043ab74339997eb2adfb09d9ba |
| institution | DOAJ |
| issn | 1076-2787 1099-0526 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Complexity |
| spelling | doaj-art-e825cc043ab74339997eb2adfb09d9ba2025-08-20T03:21:00ZengWileyComplexity1076-27871099-05262020-01-01202010.1155/2020/48341654834165Mathematical Modelling of the Inhibitory Role of Regulatory T Cells in Tumor Immune ResponseZhongtao Yang0Cuihong Yang1Yueping Dong2Yasuhiro Takeuchi3School of Mathematics and Statistics, Central China Normal University, Wuhan 430079, ChinaSchool of Mathematics and Statistics, Central China Normal University, Wuhan 430079, ChinaSchool of Mathematics and Statistics, Central China Normal University, Wuhan 430079, ChinaCollege of Science and Engineering, Aoyama Gakuin University, Sagamihara 252-5258, JapanThe immune system against tumors acts through a complex dynamical process showing a dual role. On the one hand, the immune system can activate some immune cells to kill tumor cells (TCs), such as cytotoxic T lymphocytes (CTLs) and natural killer cells (NKs), but on the other hand, more evidence shows that some immune cells can help tumor escape, such as regulatory T cells (Tregs). In this paper, we propose a tumor immune interaction model based on Tregs-mediated tumor immune escape mechanism. When helper T cells’ (HTCs) stimulation rate by the presence of identified tumor antigens is below critical value, the coexistence (tumor and immune) equilibrium is always stable in its existence region. When HTCs stimulation rate is higher than the critical value, the inhibition rate of effector cells (ECs) by Tregs can destabilize the coexistence equilibrium and cause Hopf bifurcations and produce a limit cycle. This model shows that Tregs might play a crucial role in triggering the tumor immune escape. Furthermore, we introduce the adoptive cellular immunotherapy (ACI) and monoclonal antibody immunotherapy (MAI) as the treatment to boost the immune system to fight against tumors. The numerical results show that ACI can control TCs more, while MAI can delay the inhibitory effect of Tregs on ECs. The result also shows that the combination of both immunotherapies can control TCs and reduce the inhibitory effect of Tregs better than a single immunotherapy can control.http://dx.doi.org/10.1155/2020/4834165 |
| spellingShingle | Zhongtao Yang Cuihong Yang Yueping Dong Yasuhiro Takeuchi Mathematical Modelling of the Inhibitory Role of Regulatory T Cells in Tumor Immune Response Complexity |
| title | Mathematical Modelling of the Inhibitory Role of Regulatory T Cells in Tumor Immune Response |
| title_full | Mathematical Modelling of the Inhibitory Role of Regulatory T Cells in Tumor Immune Response |
| title_fullStr | Mathematical Modelling of the Inhibitory Role of Regulatory T Cells in Tumor Immune Response |
| title_full_unstemmed | Mathematical Modelling of the Inhibitory Role of Regulatory T Cells in Tumor Immune Response |
| title_short | Mathematical Modelling of the Inhibitory Role of Regulatory T Cells in Tumor Immune Response |
| title_sort | mathematical modelling of the inhibitory role of regulatory t cells in tumor immune response |
| url | http://dx.doi.org/10.1155/2020/4834165 |
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