Missed rifampicin and isoniazid resistance by commercial molecular assays
Drug-resistant tuberculosis (TB) has poor outcomes unless resistance is detected early, ideally by commercially available molecular tests. We present a case of occult multidrug-resistant TB where both rifampicin and isoniazid resistance were missed by molecular testing and were only identified...
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| Format: | Article |
| Language: | English |
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South African Medical Association
2024-07-01
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| Series: | South African Medical Journal |
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| Online Access: | https://samajournals.co.za/index.php/samj/article/view/1779 |
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| _version_ | 1823860611811901440 |
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| author | L Richards F Ismail J Nel S V Omar |
| author_facet | L Richards F Ismail J Nel S V Omar |
| author_sort | L Richards |
| collection | DOAJ |
| description |
Drug-resistant tuberculosis (TB) has poor outcomes unless resistance is detected early, ideally by commercially available molecular tests. We present a case of occult multidrug-resistant TB where both rifampicin and isoniazid resistance were missed by molecular testing and were only identified by phenotypic testing.
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| format | Article |
| id | doaj-art-e8256ceec15e488a9774ceeb734b8b45 |
| institution | Kabale University |
| issn | 0256-9574 2078-5135 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | South African Medical Association |
| record_format | Article |
| series | South African Medical Journal |
| spelling | doaj-art-e8256ceec15e488a9774ceeb734b8b452025-02-10T12:25:51ZengSouth African Medical AssociationSouth African Medical Journal0256-95742078-51352024-07-01114710.7196/SAMJ.2024.v114i17.1779Missed rifampicin and isoniazid resistance by commercial molecular assaysL Richards0https://orcid.org/0000-0003-1723-0382F Ismail1https://orcid.org/0000-0003-3070-9806J Nel2S V Omar3https://orcid.org/0000-0001-6983-1636Division of Infectious Diseases, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaCentre for Tuberculosis, National Institute for Communicable Diseases, Division of the National Health Laboratory Service, Johannesburg, South Africa; Department of Medical Microbiology, School of Medicine, University of Pretoria, South AfricaDivision of Infectious Diseases, Department of Internal Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South AfricaCentre for Tuberculosis, National Institute for Communicable Diseases, Division of the National Health Laboratory Services, Johannesburg, South Africa, Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa and Department of Molecular Medicine, University of Witwatersrand, Johannesburg, South Africa; Department of Molecular Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa Drug-resistant tuberculosis (TB) has poor outcomes unless resistance is detected early, ideally by commercially available molecular tests. We present a case of occult multidrug-resistant TB where both rifampicin and isoniazid resistance were missed by molecular testing and were only identified by phenotypic testing. https://samajournals.co.za/index.php/samj/article/view/1779Multidrug resistant TBTB diagnostics |
| spellingShingle | L Richards F Ismail J Nel S V Omar Missed rifampicin and isoniazid resistance by commercial molecular assays South African Medical Journal Multidrug resistant TB TB diagnostics |
| title | Missed rifampicin and isoniazid resistance by commercial molecular assays |
| title_full | Missed rifampicin and isoniazid resistance by commercial molecular assays |
| title_fullStr | Missed rifampicin and isoniazid resistance by commercial molecular assays |
| title_full_unstemmed | Missed rifampicin and isoniazid resistance by commercial molecular assays |
| title_short | Missed rifampicin and isoniazid resistance by commercial molecular assays |
| title_sort | missed rifampicin and isoniazid resistance by commercial molecular assays |
| topic | Multidrug resistant TB TB diagnostics |
| url | https://samajournals.co.za/index.php/samj/article/view/1779 |
| work_keys_str_mv | AT lrichards missedrifampicinandisoniazidresistancebycommercialmolecularassays AT fismail missedrifampicinandisoniazidresistancebycommercialmolecularassays AT jnel missedrifampicinandisoniazidresistancebycommercialmolecularassays AT svomar missedrifampicinandisoniazidresistancebycommercialmolecularassays |