An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice
Currently, vaccination with influenza vaccines is still an effective strategy to prevent infection by seasonal influenza virus. However, seasonal influenza vaccines frequently fail to induce effective immune protection against rapidly changing seasonal influenza viruses and emerging zoonotic influen...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/21645515.2025.2453304 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850108847138537472 |
|---|---|
| author | Liang Xu Zhihao Yu Yifan Xu Qin Wang Guiqin Wang Benchi Li Qian Weng Yongxiang Yi Junwei Li |
| author_facet | Liang Xu Zhihao Yu Yifan Xu Qin Wang Guiqin Wang Benchi Li Qian Weng Yongxiang Yi Junwei Li |
| author_sort | Liang Xu |
| collection | DOAJ |
| description | Currently, vaccination with influenza vaccines is still an effective strategy to prevent infection by seasonal influenza virus. However, seasonal influenza vaccines frequently fail to induce effective immune protection against rapidly changing seasonal influenza viruses and emerging zoonotic influenza viruses. In addition, seasonal influenza vaccines may not confer potent protection in elderly and immunocompromised individuals. There is an urgent need to develop potent broad-spectrum influenza vaccines to address this problem. Herein, we designed an mRNA-based broad-spectrum influenza vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses. In both adult and aged mice, this universal influenza mRNA vaccine candidate stimulated robust T-cell and humoral immune responses and conferred effective protection against broad-spectrum influenza viruses in both adult and aged mice. |
| format | Article |
| id | doaj-art-e821385b4f8f403dae2c434171b04cf6 |
| institution | OA Journals |
| issn | 2164-5515 2164-554X |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj-art-e821385b4f8f403dae2c434171b04cf62025-08-20T02:38:14ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2025-12-0121110.1080/21645515.2025.2453304An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged miceLiang Xu0Zhihao Yu1Yifan Xu2Qin Wang3Guiqin Wang4Benchi Li5Qian Weng6Yongxiang Yi7Junwei Li8Department of Infectious Disease, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Infectious Disease, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Infectious Disease, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Infectious Disease, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, ChinaNanjing Advanced Academy of Life and Health, Nanjing, ChinaDepartment of Infectious Disease, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Infectious Disease, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Infectious Disease, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, ChinaDepartment of Infectious Disease, The Second Hospital of Nanjing, Affiliated to Nanjing University of Chinese Medicine, Nanjing, ChinaCurrently, vaccination with influenza vaccines is still an effective strategy to prevent infection by seasonal influenza virus. However, seasonal influenza vaccines frequently fail to induce effective immune protection against rapidly changing seasonal influenza viruses and emerging zoonotic influenza viruses. In addition, seasonal influenza vaccines may not confer potent protection in elderly and immunocompromised individuals. There is an urgent need to develop potent broad-spectrum influenza vaccines to address this problem. Herein, we designed an mRNA-based broad-spectrum influenza vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses. In both adult and aged mice, this universal influenza mRNA vaccine candidate stimulated robust T-cell and humoral immune responses and conferred effective protection against broad-spectrum influenza viruses in both adult and aged mice.https://www.tandfonline.com/doi/10.1080/21645515.2025.2453304mRNA vaccinebroad-spectrum influenza vaccinecholera toxin subunit BHA2M2eaged mice |
| spellingShingle | Liang Xu Zhihao Yu Yifan Xu Qin Wang Guiqin Wang Benchi Li Qian Weng Yongxiang Yi Junwei Li An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice Human Vaccines & Immunotherapeutics mRNA vaccine broad-spectrum influenza vaccine cholera toxin subunit B HA2 M2e aged mice |
| title | An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice |
| title_full | An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice |
| title_fullStr | An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice |
| title_full_unstemmed | An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice |
| title_short | An mRNA vaccine candidate encoding cholera toxin subunit B and conserved antigens of influenza viruses confers cross-protection against influenza a viruses in adult and aged mice |
| title_sort | mrna vaccine candidate encoding cholera toxin subunit b and conserved antigens of influenza viruses confers cross protection against influenza a viruses in adult and aged mice |
| topic | mRNA vaccine broad-spectrum influenza vaccine cholera toxin subunit B HA2 M2e aged mice |
| url | https://www.tandfonline.com/doi/10.1080/21645515.2025.2453304 |
| work_keys_str_mv | AT liangxu anmrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT zhihaoyu anmrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT yifanxu anmrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT qinwang anmrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT guiqinwang anmrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT benchili anmrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT qianweng anmrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT yongxiangyi anmrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT junweili anmrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT liangxu mrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT zhihaoyu mrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT yifanxu mrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT qinwang mrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT guiqinwang mrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT benchili mrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT qianweng mrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT yongxiangyi mrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice AT junweili mrnavaccinecandidateencodingcholeratoxinsubunitbandconservedantigensofinfluenzavirusesconferscrossprotectionagainstinfluenzaavirusesinadultandagedmice |