Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry—Lungenemphysemregister e.V.
Background Clinical trials have shown beneficial results from lung volume reduction with endobronchial coils in patients with emphysema, but comprehensive safety data are not yet available for a new coil type, Coil #4. The objective of this study is to generate real-world data (RWD) on the safety an...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-05-01
|
| Series: | COPD |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/15412555.2025.2468328 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850256061267705856 |
|---|---|
| author | Christian Grah Shiao Li Oei Joanna Krist Björn Wiesemann Bernd Schmidt Andreas Fertl Björn Schwick Ralf-Harto Hübner Birgit Becke Karl-Josef Franke Christian Geltner Stephan Eisenmann Franz Stanzel Grit Barten-Neiner Thomas Sgarbossa Katarzyna Blazejczyk Hannah Wüstefeld |
| author_facet | Christian Grah Shiao Li Oei Joanna Krist Björn Wiesemann Bernd Schmidt Andreas Fertl Björn Schwick Ralf-Harto Hübner Birgit Becke Karl-Josef Franke Christian Geltner Stephan Eisenmann Franz Stanzel Grit Barten-Neiner Thomas Sgarbossa Katarzyna Blazejczyk Hannah Wüstefeld |
| author_sort | Christian Grah |
| collection | DOAJ |
| description | Background Clinical trials have shown beneficial results from lung volume reduction with endobronchial coils in patients with emphysema, but comprehensive safety data are not yet available for a new coil type, Coil #4. The objective of this study is to generate real-world data (RWD) on the safety and efficacy of endobronchial Coil #2 and Coil #4.Methods This is a cohort study of prospectively collected data from the multicenter German Lung Emphysema Registry e.V. (LE-Registry) for patients with advanced lung emphysema undergoing lung volume reduction. All patients treated with Coil #2 or Coil #4 were evaluated at baseline and at 3 months for pulmonary function tests (FEV1, FVC, RV, DLCO, pCO2), exercise capacity, quality of life (mMRC, CAT, SGRQ), and adverse events. Descriptive statistics were used to analyze response rates and changes in clinical outcomes.Results Data from 73 patients (37 Coil #2, 36 Coil #4) enrolled between 2017 and 2024 were evaluated. At 3 months, outcome data were available for 32 Coil #2 and 26 Coil #4 patients. In the Coil #2 cohort significant improvements in RV and SGRQ were observed. The Coil #4 cohort shows significant improvements in FVC, RV, SGRQ, and CAT. Complications occurred in 37% of Coil #2 and 37% of Coil #4 patients, with 26% of patients treated with Coil #4 experiencing pneumothorax.Conclusions The outcomes observed in this RWD study are consistent with other published coil studies. The higher pneumothorax rate with Coil #4 is surprising and should be minimized by adapting the technique.Trial registration DRKS00021207 registered on 29/05/2020. |
| format | Article |
| id | doaj-art-e81efa29c5a64d8c891bdd4ccf14f253 |
| institution | OA Journals |
| issn | 1541-2555 1541-2563 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj-art-e81efa29c5a64d8c891bdd4ccf14f2532025-08-20T01:56:42ZengTaylor & Francis GroupCOPD1541-25551541-25632025-05-0122110.1080/15412555.2025.2468328Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry—Lungenemphysemregister e.V.Christian Grah0Shiao Li Oei1Joanna Krist2Björn Wiesemann3Bernd Schmidt4Andreas Fertl5Björn Schwick6Ralf-Harto Hübner7Birgit Becke8Karl-Josef Franke9Christian Geltner10Stephan Eisenmann11Franz Stanzel12Grit Barten-Neiner13Thomas Sgarbossa14Katarzyna Blazejczyk15Hannah Wüstefeld16Department of Respiratory Medicine, Clinic Havelhöhe Berlin, Berlin, GermanyResearch Institute Havelhöhe, Clinic Havelhöhe Berlin, Berlin, GermanyDepartment of Respiratory Medicine, Lung Clinic Heckeshorn, Helios Klinikum Emil von Behring, Berlin, GermanyCenter of Respiratory Medicine, Lung Clinic Immenhausen, Immenhausen, GermanyDepartment of Respiratory Medicine, DRK-Klinikum, Berlin-Mitte, GermanyDepartment of Internal Medicine and Respiratory Medicine, Krankenhaus Martha-Maria München, München, GermanyDepartment of Respirartory Medicine, Luisenhospital Aachen, GermanyDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Respiratory Medicine, Johanniter-Krankenhaus Treuenbrietzen, Treuenbrizen, GermanyDepartment of Respiratory Medicine and Critical Care Medicine, Klinikum Lüdenscheid and Witten/Herdecke University, Witten, GermanyDepartment of Respiratory Medicine, Donau-Isar-Klinikum, GermanyDepartment of Respiratory Medicine, Universitätsklinikum Halle, Halle, GermanyDepartment of Respiratory Medicine, Lungenklinik Hemer, Hemer, GermanyCAPNETZ STIFTUNG, Hannover, GermanyDepartment of Infectious Diseases, Respiratory Medicine and Critical Care, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, GermanyDepartment of Respiratory Medicine, Clinic Havelhöhe Berlin, Berlin, GermanyDepartment of Respiratory Medicine, Clinic Havelhöhe Berlin, Berlin, GermanyBackground Clinical trials have shown beneficial results from lung volume reduction with endobronchial coils in patients with emphysema, but comprehensive safety data are not yet available for a new coil type, Coil #4. The objective of this study is to generate real-world data (RWD) on the safety and efficacy of endobronchial Coil #2 and Coil #4.Methods This is a cohort study of prospectively collected data from the multicenter German Lung Emphysema Registry e.V. (LE-Registry) for patients with advanced lung emphysema undergoing lung volume reduction. All patients treated with Coil #2 or Coil #4 were evaluated at baseline and at 3 months for pulmonary function tests (FEV1, FVC, RV, DLCO, pCO2), exercise capacity, quality of life (mMRC, CAT, SGRQ), and adverse events. Descriptive statistics were used to analyze response rates and changes in clinical outcomes.Results Data from 73 patients (37 Coil #2, 36 Coil #4) enrolled between 2017 and 2024 were evaluated. At 3 months, outcome data were available for 32 Coil #2 and 26 Coil #4 patients. In the Coil #2 cohort significant improvements in RV and SGRQ were observed. The Coil #4 cohort shows significant improvements in FVC, RV, SGRQ, and CAT. Complications occurred in 37% of Coil #2 and 37% of Coil #4 patients, with 26% of patients treated with Coil #4 experiencing pneumothorax.Conclusions The outcomes observed in this RWD study are consistent with other published coil studies. The higher pneumothorax rate with Coil #4 is surprising and should be minimized by adapting the technique.Trial registration DRKS00021207 registered on 29/05/2020.https://www.tandfonline.com/doi/10.1080/15412555.2025.2468328BronchoscopyCOPDemphysemaendobronchial coilslung volume reduction |
| spellingShingle | Christian Grah Shiao Li Oei Joanna Krist Björn Wiesemann Bernd Schmidt Andreas Fertl Björn Schwick Ralf-Harto Hübner Birgit Becke Karl-Josef Franke Christian Geltner Stephan Eisenmann Franz Stanzel Grit Barten-Neiner Thomas Sgarbossa Katarzyna Blazejczyk Hannah Wüstefeld Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry—Lungenemphysemregister e.V. COPD Bronchoscopy COPD emphysema endobronchial coils lung volume reduction |
| title | Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry—Lungenemphysemregister e.V. |
| title_full | Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry—Lungenemphysemregister e.V. |
| title_fullStr | Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry—Lungenemphysemregister e.V. |
| title_full_unstemmed | Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry—Lungenemphysemregister e.V. |
| title_short | Efficacy and Safety of Lung Volume Reduction with Endobronchial Coil #2 and Coil #4 Results of the German Emphysema Registry—Lungenemphysemregister e.V. |
| title_sort | efficacy and safety of lung volume reduction with endobronchial coil 2 and coil 4 results of the german emphysema registry lungenemphysemregister e v |
| topic | Bronchoscopy COPD emphysema endobronchial coils lung volume reduction |
| url | https://www.tandfonline.com/doi/10.1080/15412555.2025.2468328 |
| work_keys_str_mv | AT christiangrah efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT shiaolioei efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT joannakrist efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT bjornwiesemann efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT berndschmidt efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT andreasfertl efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT bjornschwick efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT ralfhartohubner efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT birgitbecke efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT karljoseffranke efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT christiangeltner efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT stephaneisenmann efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT franzstanzel efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT gritbartenneiner efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT thomassgarbossa efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT katarzynablazejczyk efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev AT hannahwustefeld efficacyandsafetyoflungvolumereductionwithendobronchialcoil2andcoil4resultsofthegermanemphysemaregistrylungenemphysemregisterev |