Engineering a genome‐reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo

Engineering a genome‐reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo

Abstract Bacteria present a promising delivery system for treating human diseases. Here, we engineered the genome‐reduced human lung pathogen Mycoplasma pneumoniae as a live biotherapeutic to treat biofilm‐associated bacterial infections. This strain has a unique genetic code, which hinders gene tra...

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Bibliographic Details
Main Authors: Victoria Garrido, Carlos Piñero‐Lambea, Irene Rodriguez‐Arce, Bernhard Paetzold, Tony Ferrar, Marc Weber, Eva Garcia‐Ramallo, Carolina Gallo, María Collantes, Iván Peñuelas, Luis Serrano, María‐Jesús Grilló, María Lluch‐Senar
Format: Article
Language:English
Published: Springer Nature 2021-10-01
Series:Molecular Systems Biology
Subjects:
bacterial therapy
biofilm
in vivo
Mycoplasma
synthetic biology
Online Access:https://doi.org/10.15252/msb.202010145
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