Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography
Abstract Background This study was to evaluate the features of choroidal Sattler’s and Haller’s layer (CSHL) vessels in adults and explore its relationship with factors such as age, axial length (AL) and body mass index (BMI) by using ultra-widefield swept-source optical coherence tomography angiogr...
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BMC
2024-12-01
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| Online Access: | https://doi.org/10.1186/s12886-024-03784-0 |
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| author | Yuyao Qu Jixian Ma Rong Di Yue Bian Yuchen Li Hanze Zhang Yazhou Qin Qiuping Liu Jianqin Lei Jingming Li |
| author_facet | Yuyao Qu Jixian Ma Rong Di Yue Bian Yuchen Li Hanze Zhang Yazhou Qin Qiuping Liu Jianqin Lei Jingming Li |
| author_sort | Yuyao Qu |
| collection | DOAJ |
| description | Abstract Background This study was to evaluate the features of choroidal Sattler’s and Haller’s layer (CSHL) vessels in adults and explore its relationship with factors such as age, axial length (AL) and body mass index (BMI) by using ultra-widefield swept-source optical coherence tomography angiography (ultra-widefield SS-OCTA). Methods 24mm × 20mm fovea centered rectangular SS-OCTA scans were acquired. They were divided into 9 identical grids, with each equal size of 8 mm × 6.7 mm. OCTA artifacts were evaluated. Three-dimensional choroidal vascularity volume index (CVI) and choroidal vascular volume per unit area (CVV/a or CVV) of CSHL were calculated. The correlations of CVI and CVV with age, AL, and BMI were analyzed. Results Artifacts account for 19.30%, 18.60%, 30.23% of three inferior grids, respectively. CVI and CVV of left eyes were 30.82 ± 0.28% and 76.76 ± 2.19μm, respectively. Similary, CVI and CVV of right eyes were 31.16 ± 0.34% and 80.49 ± 3.10μm. Strong relationships of CVI (0.877, P = 0.000) and CVV (0.866, P = 0.000) were found between the two eyes in the same individual. The covariance of CVI is lower than that of CVV. Higher CVI was associated with younger age and shorter AL. Neither CVI nor CVV has association with BMI. Conclusions CVI can be a more stable parameter for describing choroidal medium and large-sized vessels compared to CVV. Aging and longer AL were associated with attenuated CSHL’s vascularity. Taken together, these findings may provide helpful and referential CSHL vascular parameters for retinal specialists to reveal risk factors of choroidal diseases. |
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| institution | OA Journals |
| issn | 1471-2415 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
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| series | BMC Ophthalmology |
| spelling | doaj-art-e81890064b68433aa63666dc31e88aff2025-08-20T01:57:09ZengBMCBMC Ophthalmology1471-24152024-12-012411810.1186/s12886-024-03784-0Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiographyYuyao Qu0Jixian Ma1Rong Di2Yue Bian3Yuchen Li4Hanze Zhang5Yazhou Qin6Qiuping Liu7Jianqin Lei8Jingming Li9Department of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Ophthalmology, First Affiliated Hospital of South China UniversityDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong UniversityDepartment of Ophthalmology, First Affiliated Hospital of Xi’an Jiaotong UniversityAbstract Background This study was to evaluate the features of choroidal Sattler’s and Haller’s layer (CSHL) vessels in adults and explore its relationship with factors such as age, axial length (AL) and body mass index (BMI) by using ultra-widefield swept-source optical coherence tomography angiography (ultra-widefield SS-OCTA). Methods 24mm × 20mm fovea centered rectangular SS-OCTA scans were acquired. They were divided into 9 identical grids, with each equal size of 8 mm × 6.7 mm. OCTA artifacts were evaluated. Three-dimensional choroidal vascularity volume index (CVI) and choroidal vascular volume per unit area (CVV/a or CVV) of CSHL were calculated. The correlations of CVI and CVV with age, AL, and BMI were analyzed. Results Artifacts account for 19.30%, 18.60%, 30.23% of three inferior grids, respectively. CVI and CVV of left eyes were 30.82 ± 0.28% and 76.76 ± 2.19μm, respectively. Similary, CVI and CVV of right eyes were 31.16 ± 0.34% and 80.49 ± 3.10μm. Strong relationships of CVI (0.877, P = 0.000) and CVV (0.866, P = 0.000) were found between the two eyes in the same individual. The covariance of CVI is lower than that of CVV. Higher CVI was associated with younger age and shorter AL. Neither CVI nor CVV has association with BMI. Conclusions CVI can be a more stable parameter for describing choroidal medium and large-sized vessels compared to CVV. Aging and longer AL were associated with attenuated CSHL’s vascularity. Taken together, these findings may provide helpful and referential CSHL vascular parameters for retinal specialists to reveal risk factors of choroidal diseases.https://doi.org/10.1186/s12886-024-03784-0Choroidal vascularity volume index (CVI)Choroidal vascular volume per unit area (CVV/a or CVV)Choroidal Sattler’s and Haller’s layer (CSHL)Ultra-widefield SS-OCTA |
| spellingShingle | Yuyao Qu Jixian Ma Rong Di Yue Bian Yuchen Li Hanze Zhang Yazhou Qin Qiuping Liu Jianqin Lei Jingming Li Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography BMC Ophthalmology Choroidal vascularity volume index (CVI) Choroidal vascular volume per unit area (CVV/a or CVV) Choroidal Sattler’s and Haller’s layer (CSHL) Ultra-widefield SS-OCTA |
| title | Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography |
| title_full | Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography |
| title_fullStr | Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography |
| title_full_unstemmed | Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography |
| title_short | Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept-source optical coherence tomography angiography |
| title_sort | grid based analysis of three dimensional choroidal sattler s and haller s layer vascularity volume index and its relation to age and axial length in adults by ultra widefield swept source optical coherence tomography angiography |
| topic | Choroidal vascularity volume index (CVI) Choroidal vascular volume per unit area (CVV/a or CVV) Choroidal Sattler’s and Haller’s layer (CSHL) Ultra-widefield SS-OCTA |
| url | https://doi.org/10.1186/s12886-024-03784-0 |
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