A temperature-sensitive metabolic valve and a transcriptional feedback loop drive rapid homeoviscous adaptation in Escherichia coli

Abstract All free-living microorganisms homeostatically maintain the fluidity of their membranes by adapting lipid composition to environmental temperatures. Here, we quantify enzymes and metabolic intermediates of the Escherichia coli fatty acid and phospholipid synthesis pathways, to describe how...

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Main Authors: Loles Hoogerland, Stefan Pieter Hendrik van den Berg, Yixing Suo, Yuta W. Moriuchi, Adja Zoumaro-Djayoon, Esther Geurken, Flora Yang, Frank Bruggeman, Michael D. Burkart, Gregory Bokinsky
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53677-5
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