EPYSQLI (SB12; Biosimilar to Reference Eculizumab) in Asian and Non‐Asian Patients With Paroxysmal Nocturnal Hemoglobinuria: Subgroup Analysis of a Global Phase III Randomized Controlled Trial

EPYSQLI (SB12; Biosimilar to Reference Eculizumab) in Asian and Non‐Asian Patients With Paroxysmal Nocturnal Hemoglobinuria: Subgroup Analysis of a Global Phase III Randomized Controlled Trial

ABSTRACT Introduction SB12 demonstrated equivalence to reference eculizumab (ECU) in complement inhibitor‐naïve patients with paroxysmal nocturnal hemoglobinuria (PNH) in the previous randomized, double‐blind, multi‐national, crossover, Phase III study. Methods The scope of this post‐hoc study was s...

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Main Authors: Jun Ho Jang, Ciprian Tomuleasa, Hanna Oliynyk, Theerin Lanamtieng, Jihye Park, Younsoo Kim, Jinah Jung, Paola Russo, Soo Min Lim, Régis Peffaultde Latour
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:eJHaem
Subjects:
Asian
clinical trial
paroxysmal nocturnal hemoglobinuria
PNH
SB12
subgroup analysis
Online Access:https://doi.org/10.1002/jha2.70020
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Summary:ABSTRACT Introduction SB12 demonstrated equivalence to reference eculizumab (ECU) in complement inhibitor‐naïve patients with paroxysmal nocturnal hemoglobinuria (PNH) in the previous randomized, double‐blind, multi‐national, crossover, Phase III study. Methods The scope of this post‐hoc study was subgroup analysis by race to compare the efficacy and safety of SB12 and ECU in PNH patients in the Asian and Non‐Asian subgroups of the Phase III study. Results Results including lactate dehydrogenase (LDH), number of units of packed red blood cells and safety as primary and secondary endpoints demonstrated comparable efficacy and safety of SB12 and ECU in Asian and Non‐Asian PNH patients, in line with the study results in the overall population. In addition, transfusion avoidance (68.1% for SB12 vs. 72.9% for ECU, p‐value of 0.4492) and hemoglobin stabilization (SB12–ECU: 6.3%, 95% confidence interval [CI] [‐21.5, 34.1] and SB12–ECU: 2.5%, 95% CI [‐24.8, 29.8] using stringent criteria) as post‐hoc endpoints were not substantially different between SB12 and ECU treatment groups in the overall population as well as in Asians and Non‐Asians. Conclusion In conclusion, this subgroup analysis by race (Asians and Non‐Asians) supports comparable efficacy and safety between SB12 and reference eculizumab in global PNH patients including no difference in transfusion avoidance effect.
ISSN:2688-6146

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