BOLD-Perfusion Coupling during Monocular and Binocular Stimulation
Previous studies have suggested that during selective activation of a subset of the zones comprising a columnar system in visual cortex, perfusion increases uniformly in all columns of the system, while increases in oxidative metabolism occur predominantly in the activated columns. This could lead t...
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | International Journal of Biomedical Imaging |
| Online Access: | http://dx.doi.org/10.1155/2008/628718 |
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| author | Claudine Gauthier Richard D. Hoge |
| author_facet | Claudine Gauthier Richard D. Hoge |
| author_sort | Claudine Gauthier |
| collection | DOAJ |
| description | Previous studies have suggested that during selective activation of a subset of the zones comprising a columnar system in visual cortex, perfusion increases uniformly in all columns of the system, while increases in oxidative metabolism occur predominantly in the activated columns. This could lead to disproportionately large blood oxygenation level-dependent (BOLD) signal increases for a given flow increase during monocular (relative to binocular) stimulation, due to contributions from columns which undergo large increases in perfusion with little or no change in oxidative metabolism. In the present study, we sought to test this hypothesis by measuring BOLD-perfusion coupling ratios in spatially averaged signals over V1 during monocular and binocular visual stimulation. It was found that, although withholding input to one eye resulted in statistically significant decreases in BOLD and perfusion signals in primary visual cortex, the ratio between BOLD and perfusion increases did not change significantly. These results do not support a gross mismatch between spatial patterns of flow and metabolism response during monocular stimulation. |
| format | Article |
| id | doaj-art-e80f809b3b344aeca8b87aac31d78b55 |
| institution | OA Journals |
| issn | 1687-4188 1687-4196 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomedical Imaging |
| spelling | doaj-art-e80f809b3b344aeca8b87aac31d78b552025-08-20T02:22:15ZengWileyInternational Journal of Biomedical Imaging1687-41881687-41962008-01-01200810.1155/2008/628718628718BOLD-Perfusion Coupling during Monocular and Binocular StimulationClaudine Gauthier0Richard D. Hoge1Unité de Neuroimagerie Fonctionnelle, Institut Universitairy of Gériatrie de Montréal, Montreal, QC, H3W 1W5, CanadaUnité de Neuroimagerie Fonctionnelle, Institut Universitairy of Gériatrie de Montréal, Montreal, QC, H3W 1W5, CanadaPrevious studies have suggested that during selective activation of a subset of the zones comprising a columnar system in visual cortex, perfusion increases uniformly in all columns of the system, while increases in oxidative metabolism occur predominantly in the activated columns. This could lead to disproportionately large blood oxygenation level-dependent (BOLD) signal increases for a given flow increase during monocular (relative to binocular) stimulation, due to contributions from columns which undergo large increases in perfusion with little or no change in oxidative metabolism. In the present study, we sought to test this hypothesis by measuring BOLD-perfusion coupling ratios in spatially averaged signals over V1 during monocular and binocular visual stimulation. It was found that, although withholding input to one eye resulted in statistically significant decreases in BOLD and perfusion signals in primary visual cortex, the ratio between BOLD and perfusion increases did not change significantly. These results do not support a gross mismatch between spatial patterns of flow and metabolism response during monocular stimulation.http://dx.doi.org/10.1155/2008/628718 |
| spellingShingle | Claudine Gauthier Richard D. Hoge BOLD-Perfusion Coupling during Monocular and Binocular Stimulation International Journal of Biomedical Imaging |
| title | BOLD-Perfusion Coupling during Monocular and Binocular Stimulation |
| title_full | BOLD-Perfusion Coupling during Monocular and Binocular Stimulation |
| title_fullStr | BOLD-Perfusion Coupling during Monocular and Binocular Stimulation |
| title_full_unstemmed | BOLD-Perfusion Coupling during Monocular and Binocular Stimulation |
| title_short | BOLD-Perfusion Coupling during Monocular and Binocular Stimulation |
| title_sort | bold perfusion coupling during monocular and binocular stimulation |
| url | http://dx.doi.org/10.1155/2008/628718 |
| work_keys_str_mv | AT claudinegauthier boldperfusioncouplingduringmonocularandbinocularstimulation AT richarddhoge boldperfusioncouplingduringmonocularandbinocularstimulation |