18F-NaF PET/CT identifies muscular and subcutaneous calcifications in both dermatomyositis- and systemic sclerosis-related calcinosis
BackgroundCalcinosis is a morbid complication of dermatomyositis (DM) and systemic sclerosis (SSc) with no effective pharmacologic treatment or validated whole-body assessment modality. 18F-NaF PET/CT may help to quantify and characterize calcinosis.MethodsIn this pilot study, we enrolled three adul...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Nuclear Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnume.2025.1593825/full |
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| author | Carrie Richardson Carrie Richardson Mehrbod S. Javadi Ami A. Shah Caoilfhionn Connolly Lilja B. Solnes Fredrick M. Wigley Laura K. Hummers Lisa Christopher-Stine |
| author_facet | Carrie Richardson Carrie Richardson Mehrbod S. Javadi Ami A. Shah Caoilfhionn Connolly Lilja B. Solnes Fredrick M. Wigley Laura K. Hummers Lisa Christopher-Stine |
| author_sort | Carrie Richardson |
| collection | DOAJ |
| description | BackgroundCalcinosis is a morbid complication of dermatomyositis (DM) and systemic sclerosis (SSc) with no effective pharmacologic treatment or validated whole-body assessment modality. 18F-NaF PET/CT may help to quantify and characterize calcinosis.MethodsIn this pilot study, we enrolled three adults with DM and three with SSc, all with new calcinosis deposits. Each underwent 18F-NaF PET/CT and clinical examination with semi-quantitative scoring of calcinosis. We described the 18F-NaF PET/CT findings and compared these to CT imaging alone as well as to clinical examination.ResultsCalcinosis was noted on 18F-NaF PET/CT in the subcutaneous tissue in all patients and the muscle in three patients, including two with SSc. The average semi-quantitative score was 23.5 by 18F-NaF PET/CT and 20 by clinical exam. Wilcoxon signed rank test indicated greater scores by 18F-NaF PET/CT than by clinical exam (p = 0.0264). 18F-NaF uptake varied among calcinosis deposits and occurred without corresponding calcifications on CT.Conclusions18F-NaF PET/CT appears to be a sensitive method of detecting and characterizing calcinosis that provides both quantitative and qualitative data beyond what can be obtained by physical examination or CT alone. 18F-NaF uptake occurs in muscle in both SSc and DM, suggesting the possibility that myositis may be driving calcinosis in a subset of patients with SSc. |
| format | Article |
| id | doaj-art-e80edbd7409e4fe7ac7db08fbf14bfc9 |
| institution | OA Journals |
| issn | 2673-8880 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nuclear Medicine |
| spelling | doaj-art-e80edbd7409e4fe7ac7db08fbf14bfc92025-08-20T02:34:51ZengFrontiers Media S.A.Frontiers in Nuclear Medicine2673-88802025-05-01510.3389/fnume.2025.1593825159382518F-NaF PET/CT identifies muscular and subcutaneous calcifications in both dermatomyositis- and systemic sclerosis-related calcinosisCarrie Richardson0Carrie Richardson1Mehrbod S. Javadi2Ami A. Shah3Caoilfhionn Connolly4Lilja B. Solnes5Fredrick M. Wigley6Laura K. Hummers7Lisa Christopher-Stine8Division of Rheumatology, Johns Hopkins University, Baltimore, MD, United StatesDivision of Rheumatology, Northwestern University, Chicago, IL, United StatesDepartment of Radiology, Johns Hopkins University, Baltimore, MD, United StatesDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, United StatesDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, United StatesDepartment of Radiology, Johns Hopkins University, Baltimore, MD, United StatesDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, United StatesDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, United StatesDivision of Rheumatology, Johns Hopkins University, Baltimore, MD, United StatesBackgroundCalcinosis is a morbid complication of dermatomyositis (DM) and systemic sclerosis (SSc) with no effective pharmacologic treatment or validated whole-body assessment modality. 18F-NaF PET/CT may help to quantify and characterize calcinosis.MethodsIn this pilot study, we enrolled three adults with DM and three with SSc, all with new calcinosis deposits. Each underwent 18F-NaF PET/CT and clinical examination with semi-quantitative scoring of calcinosis. We described the 18F-NaF PET/CT findings and compared these to CT imaging alone as well as to clinical examination.ResultsCalcinosis was noted on 18F-NaF PET/CT in the subcutaneous tissue in all patients and the muscle in three patients, including two with SSc. The average semi-quantitative score was 23.5 by 18F-NaF PET/CT and 20 by clinical exam. Wilcoxon signed rank test indicated greater scores by 18F-NaF PET/CT than by clinical exam (p = 0.0264). 18F-NaF uptake varied among calcinosis deposits and occurred without corresponding calcifications on CT.Conclusions18F-NaF PET/CT appears to be a sensitive method of detecting and characterizing calcinosis that provides both quantitative and qualitative data beyond what can be obtained by physical examination or CT alone. 18F-NaF uptake occurs in muscle in both SSc and DM, suggesting the possibility that myositis may be driving calcinosis in a subset of patients with SSc.https://www.frontiersin.org/articles/10.3389/fnume.2025.1593825/fullcalcinosisscleroderma (or systemic sclerosis)dermatomyositis18F-NaF PET/CTimaging |
| spellingShingle | Carrie Richardson Carrie Richardson Mehrbod S. Javadi Ami A. Shah Caoilfhionn Connolly Lilja B. Solnes Fredrick M. Wigley Laura K. Hummers Lisa Christopher-Stine 18F-NaF PET/CT identifies muscular and subcutaneous calcifications in both dermatomyositis- and systemic sclerosis-related calcinosis Frontiers in Nuclear Medicine calcinosis scleroderma (or systemic sclerosis) dermatomyositis 18F-NaF PET/CT imaging |
| title | 18F-NaF PET/CT identifies muscular and subcutaneous calcifications in both dermatomyositis- and systemic sclerosis-related calcinosis |
| title_full | 18F-NaF PET/CT identifies muscular and subcutaneous calcifications in both dermatomyositis- and systemic sclerosis-related calcinosis |
| title_fullStr | 18F-NaF PET/CT identifies muscular and subcutaneous calcifications in both dermatomyositis- and systemic sclerosis-related calcinosis |
| title_full_unstemmed | 18F-NaF PET/CT identifies muscular and subcutaneous calcifications in both dermatomyositis- and systemic sclerosis-related calcinosis |
| title_short | 18F-NaF PET/CT identifies muscular and subcutaneous calcifications in both dermatomyositis- and systemic sclerosis-related calcinosis |
| title_sort | 18f naf pet ct identifies muscular and subcutaneous calcifications in both dermatomyositis and systemic sclerosis related calcinosis |
| topic | calcinosis scleroderma (or systemic sclerosis) dermatomyositis 18F-NaF PET/CT imaging |
| url | https://www.frontiersin.org/articles/10.3389/fnume.2025.1593825/full |
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