The Role of Gut Microbiota in Modulating Cancer Therapy Efficacy
Gut microbiota substantially impacts pathogenic and normal immune responses and is associated with common chronic diseases. Moreover, it has a considerable effect on the efficacy of cancer therapy. Variant gut microbiota is linked with immune checkpoint inhibitors, chemo drugs, and radiotherapy resi...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Advanced Gut & Microbiome Research |
| Online Access: | http://dx.doi.org/10.1155/2024/9919868 |
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| author | Mostafa A. Madkour Rawan A. Altaf Zeinab S. Sayed Noha S. Yasen Hanan A. Elbary Reem A. Elsayed Esraa N. Mohamed Mohamed Toema Al-Hassan Soliman Wadan Mohamed H. Nafady Sanaa A. El-Benhawy |
| author_facet | Mostafa A. Madkour Rawan A. Altaf Zeinab S. Sayed Noha S. Yasen Hanan A. Elbary Reem A. Elsayed Esraa N. Mohamed Mohamed Toema Al-Hassan Soliman Wadan Mohamed H. Nafady Sanaa A. El-Benhawy |
| author_sort | Mostafa A. Madkour |
| collection | DOAJ |
| description | Gut microbiota substantially impacts pathogenic and normal immune responses and is associated with common chronic diseases. Moreover, it has a considerable effect on the efficacy of cancer therapy. Variant gut microbiota is linked with immune checkpoint inhibitors, chemo drugs, and radiotherapy resistance. Therefore, a comprehensive interpretation of the interactions between microbiota and cancer therapies is required to encourage researchers to develop new cancer prevention strategies and weaken the consequences of the different cancer therapies. This review discusses the modulating role of gut microbiota that impacts the efficacy of cancer therapies and focuses on its influence on each treatment method, in addition to delivering an overview of the gut microbiota’s role and forming relationships between bacteria, inflammation, and cancer therapies. Highlighting the mechanism of action of probiotics, antibiotics, fecal microbiota transplantation, and prebiotics promotes cancer therapies’ efficacy. Consequently, this makes the gut microbiota essential as a new adjunct augmenting the cancer therapeutic response. |
| format | Article |
| id | doaj-art-e80a923abd414b45a8c223e3ca2c1046 |
| institution | OA Journals |
| issn | 2755-1652 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Gut & Microbiome Research |
| spelling | doaj-art-e80a923abd414b45a8c223e3ca2c10462025-08-20T02:22:15ZengWileyAdvanced Gut & Microbiome Research2755-16522024-01-01202410.1155/2024/9919868The Role of Gut Microbiota in Modulating Cancer Therapy EfficacyMostafa A. Madkour0Rawan A. Altaf1Zeinab S. Sayed2Noha S. Yasen3Hanan A. Elbary4Reem A. Elsayed5Esraa N. Mohamed6Mohamed Toema7Al-Hassan Soliman Wadan8Mohamed H. Nafady9Sanaa A. El-Benhawy10Faculty of MedicineFaculty of Applied Health ScienceFaculty of Applied Health ScienceFaculty of Applied Health ScienceFaculty of Applied Health ScienceFaculty of Applied Health ScienceFaculty of Applied Health ScienceFaculty of Applied Health ScienceOral Biology DepartmentFaculty of Applied Health ScienceRadiation Sciences DepartmentGut microbiota substantially impacts pathogenic and normal immune responses and is associated with common chronic diseases. Moreover, it has a considerable effect on the efficacy of cancer therapy. Variant gut microbiota is linked with immune checkpoint inhibitors, chemo drugs, and radiotherapy resistance. Therefore, a comprehensive interpretation of the interactions between microbiota and cancer therapies is required to encourage researchers to develop new cancer prevention strategies and weaken the consequences of the different cancer therapies. This review discusses the modulating role of gut microbiota that impacts the efficacy of cancer therapies and focuses on its influence on each treatment method, in addition to delivering an overview of the gut microbiota’s role and forming relationships between bacteria, inflammation, and cancer therapies. Highlighting the mechanism of action of probiotics, antibiotics, fecal microbiota transplantation, and prebiotics promotes cancer therapies’ efficacy. Consequently, this makes the gut microbiota essential as a new adjunct augmenting the cancer therapeutic response.http://dx.doi.org/10.1155/2024/9919868 |
| spellingShingle | Mostafa A. Madkour Rawan A. Altaf Zeinab S. Sayed Noha S. Yasen Hanan A. Elbary Reem A. Elsayed Esraa N. Mohamed Mohamed Toema Al-Hassan Soliman Wadan Mohamed H. Nafady Sanaa A. El-Benhawy The Role of Gut Microbiota in Modulating Cancer Therapy Efficacy Advanced Gut & Microbiome Research |
| title | The Role of Gut Microbiota in Modulating Cancer Therapy Efficacy |
| title_full | The Role of Gut Microbiota in Modulating Cancer Therapy Efficacy |
| title_fullStr | The Role of Gut Microbiota in Modulating Cancer Therapy Efficacy |
| title_full_unstemmed | The Role of Gut Microbiota in Modulating Cancer Therapy Efficacy |
| title_short | The Role of Gut Microbiota in Modulating Cancer Therapy Efficacy |
| title_sort | role of gut microbiota in modulating cancer therapy efficacy |
| url | http://dx.doi.org/10.1155/2024/9919868 |
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