The analysis of impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources
The impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources was analyzed. On engineering software MATHCAD the program for calculation of absorbed dose produced by grid of microsources was created. To verify this algorithm the c...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"
2015-09-01
|
| Series: | Biomedical Photonics |
| Subjects: | |
| Online Access: | https://www.pdt-journal.com/jour/article/view/74 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850025246814371840 |
|---|---|
| author | N. A. Nerosin A. P. Pyshko V. V. Shapovalov A. A. Goverdovskiy |
| author_facet | N. A. Nerosin A. P. Pyshko V. V. Shapovalov A. A. Goverdovskiy |
| author_sort | N. A. Nerosin |
| collection | DOAJ |
| description | The impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources was analyzed. On engineering software MATHCAD the program for calculation of absorbed dose produced by grid of microsources was created. To verify this algorithm the calculation model for MCNP code was established and represented the area consisted of soft biological tissue or any other tissue in which the grid of microsources was incorporated. Using the developed system the value of possible systematic irregular coating of radioactivity on the microsource’s core was analyzed. The distribution of activity along the surface of microsource was simulated to create distribution of absorbed dose rate corresponding to experimental data on radiation injury. The obtained model of microsource with irregular distribution of activity was compared to conventional microsource with core coated regularly along the entire area of the silver stem by main dosimetry characteristics. The results showed that even for extremely irregular distribution of activity the distribution of dose rate produced by microsource in the tumor area was not substantially different from dose-rate field obtained for microsource with regularly coated activity. The differences in dose rates (up to 10%) in areas which were the nearest to the center of the grid were significantly lower than its decline from center to periphery of the grid. For spatial distribution of absorbed dose for specific configuration of microsource set and tracing of curves of equal level by selected cut-off the program SEEDPLAN was developed. The developed program represents precisely enough the spatial distribution of selected configuration set of microsources using results of calculation data for absorbed dose around the single microsource as basic data and may be used for optimal planning of brachytherapy with microsources. |
| format | Article |
| id | doaj-art-e8082e61e195404aaa72ea0961bb49aa |
| institution | DOAJ |
| issn | 2413-9432 |
| language | Russian |
| publishDate | 2015-09-01 |
| publisher | Non-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association" |
| record_format | Article |
| series | Biomedical Photonics |
| spelling | doaj-art-e8082e61e195404aaa72ea0961bb49aa2025-08-20T03:00:54ZrusNon-profit partnership for development of domestic photodynamic therapy and photodiagnosis "Russian Photodynamic Association"Biomedical Photonics2413-94322015-09-0143102310.24931/2413-9432-2015-4-3-10-2372The analysis of impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsourcesN. A. Nerosin0A. P. Pyshko1V. V. Shapovalov2A. A. Goverdovskiy3State Science Center of the Russian Federation – A.I. Leypunsky Institute of Physics and Power Engineering», Obninsk, RussiaState Science Center of the Russian Federation – A.I. Leypunsky Institute of Physics and Power Engineering», Obninsk, RussiaState Science Center of the Russian Federation – A.I. Leypunsky Institute of Physics and Power Engineering», Obninsk, RussiaState Science Center of the Russian Federation – A.I. Leypunsky Institute of Physics and Power Engineering», Obninsk, RussiaThe impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources was analyzed. On engineering software MATHCAD the program for calculation of absorbed dose produced by grid of microsources was created. To verify this algorithm the calculation model for MCNP code was established and represented the area consisted of soft biological tissue or any other tissue in which the grid of microsources was incorporated. Using the developed system the value of possible systematic irregular coating of radioactivity on the microsource’s core was analyzed. The distribution of activity along the surface of microsource was simulated to create distribution of absorbed dose rate corresponding to experimental data on radiation injury. The obtained model of microsource with irregular distribution of activity was compared to conventional microsource with core coated regularly along the entire area of the silver stem by main dosimetry characteristics. The results showed that even for extremely irregular distribution of activity the distribution of dose rate produced by microsource in the tumor area was not substantially different from dose-rate field obtained for microsource with regularly coated activity. The differences in dose rates (up to 10%) in areas which were the nearest to the center of the grid were significantly lower than its decline from center to periphery of the grid. For spatial distribution of absorbed dose for specific configuration of microsource set and tracing of curves of equal level by selected cut-off the program SEEDPLAN was developed. The developed program represents precisely enough the spatial distribution of selected configuration set of microsources using results of calculation data for absorbed dose around the single microsource as basic data and may be used for optimal planning of brachytherapy with microsources.https://www.pdt-journal.com/jour/article/view/74radionuclidesmicrosourcesabsorbed dose distribution |
| spellingShingle | N. A. Nerosin A. P. Pyshko V. V. Shapovalov A. A. Goverdovskiy The analysis of impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources Biomedical Photonics radionuclides microsources absorbed dose distribution |
| title | The analysis of impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources |
| title_full | The analysis of impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources |
| title_fullStr | The analysis of impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources |
| title_full_unstemmed | The analysis of impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources |
| title_short | The analysis of impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources |
| title_sort | analysis of impact of irregularity in radionuclide coating of scaffold on the distribution of absorbed dose produced by grid of microsources |
| topic | radionuclides microsources absorbed dose distribution |
| url | https://www.pdt-journal.com/jour/article/view/74 |
| work_keys_str_mv | AT nanerosin theanalysisofimpactofirregularityinradionuclidecoatingofscaffoldonthedistributionofabsorbeddoseproducedbygridofmicrosources AT appyshko theanalysisofimpactofirregularityinradionuclidecoatingofscaffoldonthedistributionofabsorbeddoseproducedbygridofmicrosources AT vvshapovalov theanalysisofimpactofirregularityinradionuclidecoatingofscaffoldonthedistributionofabsorbeddoseproducedbygridofmicrosources AT aagoverdovskiy theanalysisofimpactofirregularityinradionuclidecoatingofscaffoldonthedistributionofabsorbeddoseproducedbygridofmicrosources AT nanerosin analysisofimpactofirregularityinradionuclidecoatingofscaffoldonthedistributionofabsorbeddoseproducedbygridofmicrosources AT appyshko analysisofimpactofirregularityinradionuclidecoatingofscaffoldonthedistributionofabsorbeddoseproducedbygridofmicrosources AT vvshapovalov analysisofimpactofirregularityinradionuclidecoatingofscaffoldonthedistributionofabsorbeddoseproducedbygridofmicrosources AT aagoverdovskiy analysisofimpactofirregularityinradionuclidecoatingofscaffoldonthedistributionofabsorbeddoseproducedbygridofmicrosources |