Myricetin and chlorogenic acid from globe artichoke (Cynara cardunculus var. scolymus) as negative modulators of human Interferon I-α
The major phenolics of Cynara cardunculus var. scolymus were determined in extracts from leaves and edible parts of four genotypes named Gauchito, Madrigal, Gurí and Opal. The extracts were evaluated for their antioxidant capacity and the potential to inhibit the human recombinant alpha interferon (...
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| Language: | English |
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Elsevier
2025-07-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844025018742 |
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| author | Rosana Rotondo Milagros Bürgi Marianela Masin Ana Adalid-Martínez Jaime Prohens Gustavo R. Rodríguez Andrea M. Escalante |
| author_facet | Rosana Rotondo Milagros Bürgi Marianela Masin Ana Adalid-Martínez Jaime Prohens Gustavo R. Rodríguez Andrea M. Escalante |
| author_sort | Rosana Rotondo |
| collection | DOAJ |
| description | The major phenolics of Cynara cardunculus var. scolymus were determined in extracts from leaves and edible parts of four genotypes named Gauchito, Madrigal, Gurí and Opal. The extracts were evaluated for their antioxidant capacity and the potential to inhibit the human recombinant alpha interferon (rhIFN-α). The extracts of edible parts of Madrigal, Opal and Gurí genotypes exhibited the highest antioxidant capacity in the autographic assay, while the highest levels of chlorogenic and di-caffeoylquinic acids were in Gurí extracts. Among the flavonoids -apigenin, luteolin, myricetin and quercetin-, the Gurí and Opal genotypes showed the highest myricetin content. Leaf extracts of Gurí and Madrigal reduced the expression of fluorescent protein representing the inhibition of rhIFN-α activity by 78 % and 65 %, respectively. The inhibition is greater when the extracts have as minimum content of chlorogenic acid (600 mg kg−1) and myricetin (6 mg kg−1) in the edible part. These results indicate that these artichoke genotypes may be of great interest as functional foods for their antioxidant activity and for inhibiting IFN-α, with possible new applications in preventing oxidative processes and alleviating diseases resulting from high levels of IFN-α. |
| format | Article |
| id | doaj-art-e80799cd3be040c1966542c7109f57cb |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-e80799cd3be040c1966542c7109f57cb2025-08-20T03:50:22ZengElsevierHeliyon2405-84402025-07-011112e4348810.1016/j.heliyon.2025.e43488Myricetin and chlorogenic acid from globe artichoke (Cynara cardunculus var. scolymus) as negative modulators of human Interferon I-αRosana Rotondo0Milagros Bürgi1Marianela Masin2Ana Adalid-Martínez3Jaime Prohens4Gustavo R. Rodríguez5Andrea M. Escalante6Cátedra de Sistemas de Cultivos Intensivos-Área Horticultura, Facultad de Ciencias Agrarias de la Universidad Nacional de Rosario, Campo Experimental Villarino C.C. 14 (S2125ZAA), Zavalla, ArgentinaFacultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ruta Nacional Nº 168, km 472, C.C. 242 (S3000ZAA), Santa Fe, ArgentinaFacultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Ruta Nacional Nº 168, km 472, C.C. 242 (S3000ZAA), Santa Fe, ArgentinaInstituto de Conservación y Mejora de la Agrodiversidad Valenciana, Universitat Politècnica de València, Camino de Vera 14, 46022, Valencia, SpainInstituto de Conservación y Mejora de la Agrodiversidad Valenciana, Universitat Politècnica de València, Camino de Vera 14, 46022, Valencia, SpainInstituto de Investigaciones en Ciencias Agrarias de Rosario, Cátedra de Genética, Facultad de Ciencias Agrarias de la Universidad Nacional de Rosario, Campo Experimental Villarino C.C. 14 (S2125ZAA), Zavalla, Argentina; Corresponding author.Departamento de Química Orgánica, Facultad de Ciencias Bioquímicas y Farmacéuticas de la Universidad Nacional de Rosario, Suipacha, 531 (S2002LRK) Rosario, Argentina; Corresponding author.The major phenolics of Cynara cardunculus var. scolymus were determined in extracts from leaves and edible parts of four genotypes named Gauchito, Madrigal, Gurí and Opal. The extracts were evaluated for their antioxidant capacity and the potential to inhibit the human recombinant alpha interferon (rhIFN-α). The extracts of edible parts of Madrigal, Opal and Gurí genotypes exhibited the highest antioxidant capacity in the autographic assay, while the highest levels of chlorogenic and di-caffeoylquinic acids were in Gurí extracts. Among the flavonoids -apigenin, luteolin, myricetin and quercetin-, the Gurí and Opal genotypes showed the highest myricetin content. Leaf extracts of Gurí and Madrigal reduced the expression of fluorescent protein representing the inhibition of rhIFN-α activity by 78 % and 65 %, respectively. The inhibition is greater when the extracts have as minimum content of chlorogenic acid (600 mg kg−1) and myricetin (6 mg kg−1) in the edible part. These results indicate that these artichoke genotypes may be of great interest as functional foods for their antioxidant activity and for inhibiting IFN-α, with possible new applications in preventing oxidative processes and alleviating diseases resulting from high levels of IFN-α.http://www.sciencedirect.com/science/article/pii/S2405844025018742Bioactive compoundsAntioxidant capacityFunctional food |
| spellingShingle | Rosana Rotondo Milagros Bürgi Marianela Masin Ana Adalid-Martínez Jaime Prohens Gustavo R. Rodríguez Andrea M. Escalante Myricetin and chlorogenic acid from globe artichoke (Cynara cardunculus var. scolymus) as negative modulators of human Interferon I-α Heliyon Bioactive compounds Antioxidant capacity Functional food |
| title | Myricetin and chlorogenic acid from globe artichoke (Cynara cardunculus var. scolymus) as negative modulators of human Interferon I-α |
| title_full | Myricetin and chlorogenic acid from globe artichoke (Cynara cardunculus var. scolymus) as negative modulators of human Interferon I-α |
| title_fullStr | Myricetin and chlorogenic acid from globe artichoke (Cynara cardunculus var. scolymus) as negative modulators of human Interferon I-α |
| title_full_unstemmed | Myricetin and chlorogenic acid from globe artichoke (Cynara cardunculus var. scolymus) as negative modulators of human Interferon I-α |
| title_short | Myricetin and chlorogenic acid from globe artichoke (Cynara cardunculus var. scolymus) as negative modulators of human Interferon I-α |
| title_sort | myricetin and chlorogenic acid from globe artichoke cynara cardunculus var scolymus as negative modulators of human interferon i α |
| topic | Bioactive compounds Antioxidant capacity Functional food |
| url | http://www.sciencedirect.com/science/article/pii/S2405844025018742 |
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