The Rapidly Evolving Concept of Whole Heart Engineering
Whole heart engineering represents an incredible journey with as final destination the challenging aim to solve end-stage cardiac failure with a biocompatible and living organ equivalent. Its evolution started in 2008 with rodent organs and is nowadays moving closer to clinical application thanks to...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2017-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2017/8920940 |
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| _version_ | 1850163529224552448 |
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| author | Laura Iop Eleonora Dal Sasso Roberta Menabò Fabio Di Lisa Gino Gerosa |
| author_facet | Laura Iop Eleonora Dal Sasso Roberta Menabò Fabio Di Lisa Gino Gerosa |
| author_sort | Laura Iop |
| collection | DOAJ |
| description | Whole heart engineering represents an incredible journey with as final destination the challenging aim to solve end-stage cardiac failure with a biocompatible and living organ equivalent. Its evolution started in 2008 with rodent organs and is nowadays moving closer to clinical application thanks to scaling-up strategies to human hearts. This review will offer a comprehensive examination on the important stages to be reached for the bioengineering of the whole heart, by describing the approaches of organ decellularization, repopulation, and maturation so far applied and the novel technologies of potential interest. In addition, it will carefully address important demands that still need to be satisfied in order to move to a real clinical translation of the whole bioengineering heart concept. |
| format | Article |
| id | doaj-art-e805d77e576b4308a137d8d34050a65b |
| institution | OA Journals |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-e805d77e576b4308a137d8d34050a65b2025-08-20T02:22:15ZengWileyStem Cells International1687-966X1687-96782017-01-01201710.1155/2017/89209408920940The Rapidly Evolving Concept of Whole Heart EngineeringLaura Iop0Eleonora Dal Sasso1Roberta Menabò2Fabio Di Lisa3Gino Gerosa4Cardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Surgery, University of Padua, Padua, ItalyCardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Surgery, University of Padua, Padua, ItalyInstitute of Neuroscience, National Research Council (CNR), Padua, ItalyInstitute of Neuroscience, National Research Council (CNR), Padua, ItalyCardiovascular Regenerative Medicine Group, Department of Cardiac, Thoracic and Vascular Surgery, University of Padua, Padua, ItalyWhole heart engineering represents an incredible journey with as final destination the challenging aim to solve end-stage cardiac failure with a biocompatible and living organ equivalent. Its evolution started in 2008 with rodent organs and is nowadays moving closer to clinical application thanks to scaling-up strategies to human hearts. This review will offer a comprehensive examination on the important stages to be reached for the bioengineering of the whole heart, by describing the approaches of organ decellularization, repopulation, and maturation so far applied and the novel technologies of potential interest. In addition, it will carefully address important demands that still need to be satisfied in order to move to a real clinical translation of the whole bioengineering heart concept.http://dx.doi.org/10.1155/2017/8920940 |
| spellingShingle | Laura Iop Eleonora Dal Sasso Roberta Menabò Fabio Di Lisa Gino Gerosa The Rapidly Evolving Concept of Whole Heart Engineering Stem Cells International |
| title | The Rapidly Evolving Concept of Whole Heart Engineering |
| title_full | The Rapidly Evolving Concept of Whole Heart Engineering |
| title_fullStr | The Rapidly Evolving Concept of Whole Heart Engineering |
| title_full_unstemmed | The Rapidly Evolving Concept of Whole Heart Engineering |
| title_short | The Rapidly Evolving Concept of Whole Heart Engineering |
| title_sort | rapidly evolving concept of whole heart engineering |
| url | http://dx.doi.org/10.1155/2017/8920940 |
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