TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment
In restricted regions of the rodent brain, neurogenesis persists throughout life, hinting that perhaps similar phenomena may exist in humans. Neural stem cells (NSCs) that reside within the ventricular-subventricular zone (V-SVZ) continually produce functional cells, including neurons that integrate...
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MDPI AG
2025-04-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/15/4/573 |
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| author | David M. Feliciano Angelique Bordey |
| author_facet | David M. Feliciano Angelique Bordey |
| author_sort | David M. Feliciano |
| collection | DOAJ |
| description | In restricted regions of the rodent brain, neurogenesis persists throughout life, hinting that perhaps similar phenomena may exist in humans. Neural stem cells (NSCs) that reside within the ventricular-subventricular zone (V-SVZ) continually produce functional cells, including neurons that integrate into the olfactory bulb circuitry. The ability to achieve this feat is based on genetically encoded transcriptional programs that are controlled by environmentally regulated post-transcriptional signaling pathways. One such pathway that molds V-SVZ neurogenesis is the mTOR pathway. This pathway integrates nutrient sufficiency with growth factor signaling to control distinct steps of neurogenesis. Alterations in mTOR pathway signaling occur in numerous neurodevelopmental disorders. Here, we provide a narrative review for the role of the mTOR pathway in this process and discuss the use of this region to study the mTOR pathway in both health and disease. |
| format | Article |
| id | doaj-art-e80260bd3600401c9891e727bc374264 |
| institution | DOAJ |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-e80260bd3600401c9891e727bc3742642025-08-20T03:14:20ZengMDPI AGBiomolecules2218-273X2025-04-0115457310.3390/biom15040573TSC-mTORC1 Pathway in Postnatal V-SVZ NeurodevelopmentDavid M. Feliciano0Angelique Bordey1Department of Biological Sciences, Clemson University, Clemson, SC 29634-0314, USADepartments of Neurosurgery, and Cellular & Molecular Physiology, Wu Tsai Institute, Yale University School of Medicine, New Haven, CT 06520-8082, USAIn restricted regions of the rodent brain, neurogenesis persists throughout life, hinting that perhaps similar phenomena may exist in humans. Neural stem cells (NSCs) that reside within the ventricular-subventricular zone (V-SVZ) continually produce functional cells, including neurons that integrate into the olfactory bulb circuitry. The ability to achieve this feat is based on genetically encoded transcriptional programs that are controlled by environmentally regulated post-transcriptional signaling pathways. One such pathway that molds V-SVZ neurogenesis is the mTOR pathway. This pathway integrates nutrient sufficiency with growth factor signaling to control distinct steps of neurogenesis. Alterations in mTOR pathway signaling occur in numerous neurodevelopmental disorders. Here, we provide a narrative review for the role of the mTOR pathway in this process and discuss the use of this region to study the mTOR pathway in both health and disease.https://www.mdpi.com/2218-273X/15/4/573neurogenesismTORTSCmTORC1TSC1TSC2 |
| spellingShingle | David M. Feliciano Angelique Bordey TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment Biomolecules neurogenesis mTOR TSC mTORC1 TSC1 TSC2 |
| title | TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment |
| title_full | TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment |
| title_fullStr | TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment |
| title_full_unstemmed | TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment |
| title_short | TSC-mTORC1 Pathway in Postnatal V-SVZ Neurodevelopment |
| title_sort | tsc mtorc1 pathway in postnatal v svz neurodevelopment |
| topic | neurogenesis mTOR TSC mTORC1 TSC1 TSC2 |
| url | https://www.mdpi.com/2218-273X/15/4/573 |
| work_keys_str_mv | AT davidmfeliciano tscmtorc1pathwayinpostnatalvsvzneurodevelopment AT angeliquebordey tscmtorc1pathwayinpostnatalvsvzneurodevelopment |