Treatment of osteoradionecrosis of the jaw with injectable platelet-rich fibrin (i-PRF): case series
Objective: This study evaluated the use of autogenous blood concentrate (injectable platelet-rich fibrin) [i-PRF] for promoting soft tissue healing in osteoradionecrosis (ORN) lesions in patients who underwent head and neck radiotherapy. Material and Methods: This study included five ORN lesions in...
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| Format: | Article |
| Language: | English |
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Universidade Estadual Paulista
2024-08-01
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| Series: | Brazilian Dental Science |
| Online Access: | https://ojs.ict.unesp.br/index.php/cob/article/view/4264 |
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| author | Nuryê Rezende Prisinoto Guilherme José Pimentel Lopes de Oliveira Roberta de Oliveira Alves Sérgio Vitorino Cardoso Lívia Bonjardim Lima Priscilla Barbosa Ferreira Soares |
| author_facet | Nuryê Rezende Prisinoto Guilherme José Pimentel Lopes de Oliveira Roberta de Oliveira Alves Sérgio Vitorino Cardoso Lívia Bonjardim Lima Priscilla Barbosa Ferreira Soares |
| author_sort | Nuryê Rezende Prisinoto |
| collection | DOAJ |
| description |
Objective: This study evaluated the use of autogenous blood concentrate (injectable platelet-rich fibrin) [i-PRF] for promoting soft tissue healing in osteoradionecrosis (ORN) lesions in patients who underwent head and neck radiotherapy. Material and Methods: This study included five ORN lesions in four patients who were treated with i-PRF (applied weekly for 4 weeks to the lesions). Soft tissue features were evaluated through clinical analysis at baseline and at 7, 15, 30, 60, and 90 days after the first session of i-PRF. Extension of the bone lesions was evaluated radiographically. Patient-centered related outcomes were evaluated using quality-of-life questionnaires at baseline and 90 days after the first treatment session. Quality of life data were analyzed using descriptive and frequency statistics and the Wilcoxon test. Results: Of the 5 treated lesions, 1 was completely closed and 3 remained open. The open lesions showed increased necrotic tissue exposure. No changes were observed in the radiographic appearance of the lesions. There was also no impact on the patient’s quality of life. Conclusion: The results suggest that the majority of ORN lesions remained stable after the application of i-PRF, with a slight improvement in the quality of the mucosa around the lesions. Furthermore, it was observed that i-PRF did not compromise the quality of life of patients during treatment.
KEYWORDS
Head and neck neoplasms; Osteoradionecrosis; Platelet-rich fibrin; Quality of life; Radiotherapy
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| format | Article |
| id | doaj-art-e8018fc42cbb417f8cb919c353ea20ce |
| institution | Kabale University |
| issn | 2178-6011 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Universidade Estadual Paulista |
| record_format | Article |
| series | Brazilian Dental Science |
| spelling | doaj-art-e8018fc42cbb417f8cb919c353ea20ce2025-08-22T13:49:33ZengUniversidade Estadual PaulistaBrazilian Dental Science2178-60112024-08-0127210.4322/bds.2024.e4264Treatment of osteoradionecrosis of the jaw with injectable platelet-rich fibrin (i-PRF): case seriesNuryê Rezende Prisinoto0https://orcid.org/0000-0001-6254-8854Guilherme José Pimentel Lopes de Oliveira1https://orcid.org/0000-0001-8778-0115Roberta de Oliveira Alves2https://orcid.org/0000-0001-6528-3038Sérgio Vitorino Cardoso3https://orcid.org/0000-0003-1809-0617Lívia Bonjardim Lima4https://orcid.org/0000-0002-9924-4077Priscilla Barbosa Ferreira Soares5https://orcid.org/0000-0002-4492-8957Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Periodontia e Implantodontia. Uberlândia, MG, Brazil.Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Periodontia e Implantodontia. Uberlândia, MG, Brazil.Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Periodontia e Implantodontia. Uberlândia, MG, Brazil.Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Patologia Bucal. Uberlândia, MG, Brazil.Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Cirurgia Traumatologia Buco Maxilo Facial e Implantodontia. Uberlândia, MG, Brazil.Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Periodontia e Implantodontia. Uberlândia, MG, Brazil. Objective: This study evaluated the use of autogenous blood concentrate (injectable platelet-rich fibrin) [i-PRF] for promoting soft tissue healing in osteoradionecrosis (ORN) lesions in patients who underwent head and neck radiotherapy. Material and Methods: This study included five ORN lesions in four patients who were treated with i-PRF (applied weekly for 4 weeks to the lesions). Soft tissue features were evaluated through clinical analysis at baseline and at 7, 15, 30, 60, and 90 days after the first session of i-PRF. Extension of the bone lesions was evaluated radiographically. Patient-centered related outcomes were evaluated using quality-of-life questionnaires at baseline and 90 days after the first treatment session. Quality of life data were analyzed using descriptive and frequency statistics and the Wilcoxon test. Results: Of the 5 treated lesions, 1 was completely closed and 3 remained open. The open lesions showed increased necrotic tissue exposure. No changes were observed in the radiographic appearance of the lesions. There was also no impact on the patient’s quality of life. Conclusion: The results suggest that the majority of ORN lesions remained stable after the application of i-PRF, with a slight improvement in the quality of the mucosa around the lesions. Furthermore, it was observed that i-PRF did not compromise the quality of life of patients during treatment. KEYWORDS Head and neck neoplasms; Osteoradionecrosis; Platelet-rich fibrin; Quality of life; Radiotherapy https://ojs.ict.unesp.br/index.php/cob/article/view/4264 |
| spellingShingle | Nuryê Rezende Prisinoto Guilherme José Pimentel Lopes de Oliveira Roberta de Oliveira Alves Sérgio Vitorino Cardoso Lívia Bonjardim Lima Priscilla Barbosa Ferreira Soares Treatment of osteoradionecrosis of the jaw with injectable platelet-rich fibrin (i-PRF): case series Brazilian Dental Science |
| title | Treatment of osteoradionecrosis of the jaw with injectable platelet-rich fibrin (i-PRF): case series |
| title_full | Treatment of osteoradionecrosis of the jaw with injectable platelet-rich fibrin (i-PRF): case series |
| title_fullStr | Treatment of osteoradionecrosis of the jaw with injectable platelet-rich fibrin (i-PRF): case series |
| title_full_unstemmed | Treatment of osteoradionecrosis of the jaw with injectable platelet-rich fibrin (i-PRF): case series |
| title_short | Treatment of osteoradionecrosis of the jaw with injectable platelet-rich fibrin (i-PRF): case series |
| title_sort | treatment of osteoradionecrosis of the jaw with injectable platelet rich fibrin i prf case series |
| url | https://ojs.ict.unesp.br/index.php/cob/article/view/4264 |
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