Short-term blood pressure variability and brain functional network connectivity in older adults
Background: Blood pressure variability is increasingly linked with cerebrovascular disease and Alzheimer's disease, independent of mean blood pressure levels. Elevated blood pressure variability is also associated with attenuated cerebrovascular reactivity, which may have implications for funct...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-03-01
|
| Series: | NeuroImage: Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666956024000047 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849691349272494080 |
|---|---|
| author | Isabel J. Sible Jung Yun Jang Anna E. Blanken John Paul M. Alitin Allie Engstrom Shubir Dutt Anisa J. Marshall Arunima Kapoor Fatemah Shenasa Aimée Gaubert Amy Nguyen Farrah Ferrer David R. Bradford Kathleen E. Rodgers Mara Mather S. Duke Han Daniel A. Nation |
| author_facet | Isabel J. Sible Jung Yun Jang Anna E. Blanken John Paul M. Alitin Allie Engstrom Shubir Dutt Anisa J. Marshall Arunima Kapoor Fatemah Shenasa Aimée Gaubert Amy Nguyen Farrah Ferrer David R. Bradford Kathleen E. Rodgers Mara Mather S. Duke Han Daniel A. Nation |
| author_sort | Isabel J. Sible |
| collection | DOAJ |
| description | Background: Blood pressure variability is increasingly linked with cerebrovascular disease and Alzheimer's disease, independent of mean blood pressure levels. Elevated blood pressure variability is also associated with attenuated cerebrovascular reactivity, which may have implications for functional hyperemia underpinning brain network connectivity. It remains unclear whether blood pressure variability is related to functional network connectivity. We examined relationships between beat-to-beat blood pressure variability and functional connectivity in brain networks vulnerable to aging and Alzheimer's disease. Methods: 53 community-dwelling older adults (mean [SD] age = 69.9 [7.5] years, 62.3% female) without history of dementia or clinical stroke underwent continuous blood pressure monitoring and resting state fMRI scan. Blood pressure variability was calculated as variability independent of mean. Functional connectivity was determined by resting state fMRI for several brain networks: default, salience, dorsal attention, fronto-parietal, and language. Multiple linear regression examined relationships between short-term blood pressure variability and functional network connectivity. Results: Elevated short-term blood pressure variability was associated with lower functional connectivity in the default network (systolic: standardized ß = −0.30 [95% CI -0.59, −0.01], p = .04). There were no significant associations between blood pressure variability and connectivity in other functional networks or between mean blood pressure and functional connectivity in any network. Discussion: Older adults with elevated short-term blood pressure variability exhibit lower resting state functional connectivity in the default network. Findings support the role of blood pressure variability in neurovascular dysfunction and Alzheimer's disease. Blood pressure variability may represent an understudied early vascular risk factor for neurovascular dysfunction relevant to Alzheimer's disease, with potential therapeutic implications. |
| format | Article |
| id | doaj-art-e800f65c28d44fd79d1692f10bbe4d8d |
| institution | DOAJ |
| issn | 2666-9560 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Reports |
| spelling | doaj-art-e800f65c28d44fd79d1692f10bbe4d8d2025-08-20T03:21:03ZengElsevierNeuroImage: Reports2666-95602024-03-014110019810.1016/j.ynirp.2024.100198Short-term blood pressure variability and brain functional network connectivity in older adultsIsabel J. Sible0Jung Yun Jang1Anna E. Blanken2John Paul M. Alitin3Allie Engstrom4Shubir Dutt5Anisa J. Marshall6Arunima Kapoor7Fatemah Shenasa8Aimée Gaubert9Amy Nguyen10Farrah Ferrer11David R. Bradford12Kathleen E. Rodgers13Mara Mather14S. Duke Han15Daniel A. Nation16Department of Psychology, University of Southern California, Los Angeles, CA 90089, USAInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USASan Francisco Veterans Affairs Health Care System, San Francisco, CA, 94121, USA; Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, 94158, USADavis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USADepartment of Psychological Science, University of California Irvine, Irvine, CA 92697, USADepartment of Psychiatry and Behavioral Sciences, University of California, San Francisco, CA, 94158, USADepartment of Psychology, University of Southern California, Los Angeles, CA 90089, USADepartment of Psychological Science, University of California Irvine, Irvine, CA 92697, USADepartment of Psychological Science, University of California Irvine, Irvine, CA 92697, USADavis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USADavis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USADavis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USACenter for Innovation in Brain Science, Department of Pharmacology, The University of Arizona, Tucson, AZ, 85721, USACenter for Innovation in Brain Science, Department of Pharmacology, The University of Arizona, Tucson, AZ, 85721, USADepartment of Psychology, University of Southern California, Los Angeles, CA 90089, USA; Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USADepartment of Psychology, University of Southern California, Los Angeles, CA 90089, USA; Department of Family Medicine, Keck School of Medicine of University of Southern California, Alhambra, CA 91803, USADavis School of Gerontology, University of Southern California, Los Angeles, CA 90089, USA; Corresponding author. University of Southern California Leonard Davis School of Gerontology 3715 McClintock Ave Los Angeles, CA. 90089, USA.Background: Blood pressure variability is increasingly linked with cerebrovascular disease and Alzheimer's disease, independent of mean blood pressure levels. Elevated blood pressure variability is also associated with attenuated cerebrovascular reactivity, which may have implications for functional hyperemia underpinning brain network connectivity. It remains unclear whether blood pressure variability is related to functional network connectivity. We examined relationships between beat-to-beat blood pressure variability and functional connectivity in brain networks vulnerable to aging and Alzheimer's disease. Methods: 53 community-dwelling older adults (mean [SD] age = 69.9 [7.5] years, 62.3% female) without history of dementia or clinical stroke underwent continuous blood pressure monitoring and resting state fMRI scan. Blood pressure variability was calculated as variability independent of mean. Functional connectivity was determined by resting state fMRI for several brain networks: default, salience, dorsal attention, fronto-parietal, and language. Multiple linear regression examined relationships between short-term blood pressure variability and functional network connectivity. Results: Elevated short-term blood pressure variability was associated with lower functional connectivity in the default network (systolic: standardized ß = −0.30 [95% CI -0.59, −0.01], p = .04). There were no significant associations between blood pressure variability and connectivity in other functional networks or between mean blood pressure and functional connectivity in any network. Discussion: Older adults with elevated short-term blood pressure variability exhibit lower resting state functional connectivity in the default network. Findings support the role of blood pressure variability in neurovascular dysfunction and Alzheimer's disease. Blood pressure variability may represent an understudied early vascular risk factor for neurovascular dysfunction relevant to Alzheimer's disease, with potential therapeutic implications.http://www.sciencedirect.com/science/article/pii/S2666956024000047Blood pressure variabilityFunctional connectivityDefault network |
| spellingShingle | Isabel J. Sible Jung Yun Jang Anna E. Blanken John Paul M. Alitin Allie Engstrom Shubir Dutt Anisa J. Marshall Arunima Kapoor Fatemah Shenasa Aimée Gaubert Amy Nguyen Farrah Ferrer David R. Bradford Kathleen E. Rodgers Mara Mather S. Duke Han Daniel A. Nation Short-term blood pressure variability and brain functional network connectivity in older adults NeuroImage: Reports Blood pressure variability Functional connectivity Default network |
| title | Short-term blood pressure variability and brain functional network connectivity in older adults |
| title_full | Short-term blood pressure variability and brain functional network connectivity in older adults |
| title_fullStr | Short-term blood pressure variability and brain functional network connectivity in older adults |
| title_full_unstemmed | Short-term blood pressure variability and brain functional network connectivity in older adults |
| title_short | Short-term blood pressure variability and brain functional network connectivity in older adults |
| title_sort | short term blood pressure variability and brain functional network connectivity in older adults |
| topic | Blood pressure variability Functional connectivity Default network |
| url | http://www.sciencedirect.com/science/article/pii/S2666956024000047 |
| work_keys_str_mv | AT isabeljsible shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT jungyunjang shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT annaeblanken shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT johnpaulmalitin shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT allieengstrom shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT shubirdutt shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT anisajmarshall shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT arunimakapoor shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT fatemahshenasa shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT aimeegaubert shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT amynguyen shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT farrahferrer shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT davidrbradford shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT kathleenerodgers shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT maramather shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT sdukehan shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults AT danielanation shorttermbloodpressurevariabilityandbrainfunctionalnetworkconnectivityinolderadults |