“It seems enormously valuable to me.” Perspectives of Dutch (potential) carriers of genetic FTD on onset-predictive biomarker testing

“It seems enormously valuable to me.” Perspectives of Dutch (potential) carriers of genetic FTD on onset-predictive biomarker testing

Abstract Background Onset-predictive biomarker tests (OPBT) in genetic frontotemporal dementia (FTD) may be used to recruit mutation carriers into preventive clinical trials before symptoms manifest. This would require disclosure of OPBT results to potential participants. This study investigates the...

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Bibliographic Details
Main Authors: Charlotte H. Graafland, Harro Seelaar, Jessica L. Panman, Lize C. Jiskoot, Tjitske Kleefstra, Jackie M. Poos, Edo Richard, Maartje H.N. Schermer, John C. van Swieten, Laura Donker Kaat, Eline M. Bunnik
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Onset prediction
Frontotemporal dementia
Biomarker
Ethics
Genetic counselling
Clinical trial recruitment
Online Access:https://doi.org/10.1186/s13195-025-01749-z
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