Current Clinical Trials for the Monkeypox Virus
Background Monkeypox (MPX) is a zoonotic Orthopoxvirus causing smallpox-like symptoms. Before April 2022, MPX cases outside Africa were rare. The virus can spread through skin-to-skin contact, sexual contact, respiratory droplets, and household items such as towels and blankets. Aim This study was a...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-04-01
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| Series: | Dr. Sulaiman Al Habib Medical Journal |
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| Online Access: | https://journals.lww.com/10.1007/s44229-023-00029-y |
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| _version_ | 1849405285281562624 |
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| author | Mahmoud Kandeel |
| author_facet | Mahmoud Kandeel |
| author_sort | Mahmoud Kandeel |
| collection | DOAJ |
| description | Background
Monkeypox (MPX) is a zoonotic Orthopoxvirus causing smallpox-like symptoms. Before April 2022, MPX cases outside Africa were rare. The virus can spread through skin-to-skin contact, sexual contact, respiratory droplets, and household items such as towels and blankets.
Aim
This study was aimed at highlighting the dire need for vaccination and treatment against this infection. Several in-process clinical trials that may help overcome MPX infection are discussed.
Methods
A search for recent clinical studies was conducted in the clinicaltrials.gov database.
Results
A total of 15 trials were identified. After February 2022, 14 new trials were launched. Of the 15 trials, 9 were observational studies, 3 were treatment studies and 3 were preventive studies. MPX clinical trial topics were classified into four broad categories: MPX virus shedding and clearance; response to MPX vaccine; antiviral treatment for MPX; and awareness regarding MPX. One medication, tecovirimat, and two vaccines are currently in clinical trials.
Conclusions
Few treatments and vaccines are under evaluation. Although multiple trials have been conducted, evidence to determine the present state of MPX infection is currently insufficient. Global collaboration is required to achieve complete understanding of the epidemiology, prevention and control of MPX. |
| format | Article |
| id | doaj-art-e7fc5afd1b614a6e9ab452c6c06e8d52 |
| institution | Kabale University |
| issn | 2666-819X 2590-3349 |
| language | English |
| publishDate | 2023-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dr. Sulaiman Al Habib Medical Journal |
| spelling | doaj-art-e7fc5afd1b614a6e9ab452c6c06e8d522025-08-20T03:36:42ZengWolters Kluwer Medknow PublicationsDr. Sulaiman Al Habib Medical Journal2666-819X2590-33492023-04-0152505710.1007/s44229-023-00029-yCurrent Clinical Trials for the Monkeypox VirusMahmoud KandeelBackground Monkeypox (MPX) is a zoonotic Orthopoxvirus causing smallpox-like symptoms. Before April 2022, MPX cases outside Africa were rare. The virus can spread through skin-to-skin contact, sexual contact, respiratory droplets, and household items such as towels and blankets. Aim This study was aimed at highlighting the dire need for vaccination and treatment against this infection. Several in-process clinical trials that may help overcome MPX infection are discussed. Methods A search for recent clinical studies was conducted in the clinicaltrials.gov database. Results A total of 15 trials were identified. After February 2022, 14 new trials were launched. Of the 15 trials, 9 were observational studies, 3 were treatment studies and 3 were preventive studies. MPX clinical trial topics were classified into four broad categories: MPX virus shedding and clearance; response to MPX vaccine; antiviral treatment for MPX; and awareness regarding MPX. One medication, tecovirimat, and two vaccines are currently in clinical trials. Conclusions Few treatments and vaccines are under evaluation. Although multiple trials have been conducted, evidence to determine the present state of MPX infection is currently insufficient. Global collaboration is required to achieve complete understanding of the epidemiology, prevention and control of MPX.https://journals.lww.com/10.1007/s44229-023-00029-ymonkeypoxvirusclinical trialsvaccinetreatment |
| spellingShingle | Mahmoud Kandeel Current Clinical Trials for the Monkeypox Virus Dr. Sulaiman Al Habib Medical Journal monkeypox virus clinical trials vaccine treatment |
| title | Current Clinical Trials for the Monkeypox Virus |
| title_full | Current Clinical Trials for the Monkeypox Virus |
| title_fullStr | Current Clinical Trials for the Monkeypox Virus |
| title_full_unstemmed | Current Clinical Trials for the Monkeypox Virus |
| title_short | Current Clinical Trials for the Monkeypox Virus |
| title_sort | current clinical trials for the monkeypox virus |
| topic | monkeypox virus clinical trials vaccine treatment |
| url | https://journals.lww.com/10.1007/s44229-023-00029-y |
| work_keys_str_mv | AT mahmoudkandeel currentclinicaltrialsforthemonkeypoxvirus |