Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas
Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by chronic infection with human papillomavirus (HPV), leading to disseminated flat-topped papules and pityriasis versicolor-like lesions. Patients with EV are predisposed to developing non-melanoma skin cancers, particularly...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1565977/full |
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| author | Zijing Zhang Chuanbo Liu Jinsheng Li |
| author_facet | Zijing Zhang Chuanbo Liu Jinsheng Li |
| author_sort | Zijing Zhang |
| collection | DOAJ |
| description | Epidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by chronic infection with human papillomavirus (HPV), leading to disseminated flat-topped papules and pityriasis versicolor-like lesions. Patients with EV are predisposed to developing non-melanoma skin cancers, particularly squamous cell carcinoma (SCC) in sun-exposed areas. Currently, there is no definitive cure for EV, and management remains largely supportive and symptomatic. We report a case of EV in a 38-year-old male, presenting with classical clinical features and histopathological findings, complicated by the simultaneous development of squamous cell carcinoma(SCC) and basal cell carcinoma (BCC). This case highlights the oncogenic potential of EV-associated HPV subtypes and the importance of regular dermatologic surveillance in affected individuals. |
| format | Article |
| id | doaj-art-e7fa29bd87d44c7dbba287d05d2800ff |
| institution | OA Journals |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-e7fa29bd87d44c7dbba287d05d2800ff2025-08-20T02:03:04ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-06-011210.3389/fmed.2025.15659771565977Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomasZijing Zhang0Chuanbo Liu1Jinsheng Li2The Fourth Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, ChinaDepartment of Plastic and Cosmetic Surgery, Affiliated Hangzhou First People's Hospital, Hangzhou, Zhejiang, ChinaDepartment of Plastic and Cosmetic Surgery, Affiliated Hangzhou First People's Hospital, Hangzhou, Zhejiang, ChinaEpidermodysplasia verruciformis (EV) is a rare genodermatosis characterized by chronic infection with human papillomavirus (HPV), leading to disseminated flat-topped papules and pityriasis versicolor-like lesions. Patients with EV are predisposed to developing non-melanoma skin cancers, particularly squamous cell carcinoma (SCC) in sun-exposed areas. Currently, there is no definitive cure for EV, and management remains largely supportive and symptomatic. We report a case of EV in a 38-year-old male, presenting with classical clinical features and histopathological findings, complicated by the simultaneous development of squamous cell carcinoma(SCC) and basal cell carcinoma (BCC). This case highlights the oncogenic potential of EV-associated HPV subtypes and the importance of regular dermatologic surveillance in affected individuals.https://www.frontiersin.org/articles/10.3389/fmed.2025.1565977/fullepidermodysplasia verruciformissquamous cell carcinomabasal cell carcinomahistopathological examinationmalignancy |
| spellingShingle | Zijing Zhang Chuanbo Liu Jinsheng Li Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas Frontiers in Medicine epidermodysplasia verruciformis squamous cell carcinoma basal cell carcinoma histopathological examination malignancy |
| title | Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas |
| title_full | Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas |
| title_fullStr | Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas |
| title_full_unstemmed | Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas |
| title_short | Case Report: Epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas |
| title_sort | case report epidermodysplasia verruciformis with multiple squamous and basal cell carcinomas |
| topic | epidermodysplasia verruciformis squamous cell carcinoma basal cell carcinoma histopathological examination malignancy |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1565977/full |
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