A Review of the Nonsurgical Treatment of Oral Leukoplakia
The aim of this paper was to assess the nonsurgical treatment of oral leukoplakia (OL). A medline search from 1983 to 2009 was conducted. The topical or systemic nonsurgical treatments or combination of both was reviewed. The primary outcomes of interest were clinical resolution, malignant transform...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | International Journal of Dentistry |
| Online Access: | http://dx.doi.org/10.1155/2010/186018 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849691438213758976 |
|---|---|
| author | Adriana Spinola Ribeiro Patrícia Ribeiro Salles Tarcília Aparecida da Silva Ricardo Alves Mesquita |
| author_facet | Adriana Spinola Ribeiro Patrícia Ribeiro Salles Tarcília Aparecida da Silva Ricardo Alves Mesquita |
| author_sort | Adriana Spinola Ribeiro |
| collection | DOAJ |
| description | The aim of this paper was to assess the nonsurgical treatment of oral leukoplakia (OL). A medline search from 1983 to 2009 was conducted. The topical or systemic nonsurgical treatments or combination of both was reviewed. The primary outcomes of interest were clinical resolution, malignant transformation, follow-up, and recurrence of OL. Studies showed a rate higher than 50% of clinical resolution with photodynamic therapy, beta-carotene, lycopene, or vitamin A. Few studies reported rates of recurrence from 5 to 67% and of malignant transformation from 8 to 23%. There is a lack of randomized clinical trials that assess the effectiveness of nonsurgical treatment of OL. At this time, randomized controlled trials for nonsurgical treatment of OL demonstrate no evidence of effective treatment in preventing malignant transformation and recurrence. It reinforces that even after clinical resolution, OL should be regularly followed. |
| format | Article |
| id | doaj-art-e7fa08387f004f61a95ef8d4d64874f7 |
| institution | DOAJ |
| issn | 1687-8728 1687-8736 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Dentistry |
| spelling | doaj-art-e7fa08387f004f61a95ef8d4d64874f72025-08-20T03:21:02ZengWileyInternational Journal of Dentistry1687-87281687-87362010-01-01201010.1155/2010/186018186018A Review of the Nonsurgical Treatment of Oral LeukoplakiaAdriana Spinola Ribeiro0Patrícia Ribeiro Salles1Tarcília Aparecida da Silva2Ricardo Alves Mesquita3Department of Oral Surgery, Medicine and Pathology, Dental School, Federal University of Minas Gerais, CEP 31.270-901, Belo Horizonte, Minas Gerais, BrazilDepartment of Oral Surgery, Medicine and Pathology, Dental School, Federal University of Minas Gerais, CEP 31.270-901, Belo Horizonte, Minas Gerais, BrazilDepartment of Oral Surgery, Medicine and Pathology, Dental School, Federal University of Minas Gerais, CEP 31.270-901, Belo Horizonte, Minas Gerais, BrazilDepartment of Oral Surgery, Medicine and Pathology, Dental School, Federal University of Minas Gerais, CEP 31.270-901, Belo Horizonte, Minas Gerais, BrazilThe aim of this paper was to assess the nonsurgical treatment of oral leukoplakia (OL). A medline search from 1983 to 2009 was conducted. The topical or systemic nonsurgical treatments or combination of both was reviewed. The primary outcomes of interest were clinical resolution, malignant transformation, follow-up, and recurrence of OL. Studies showed a rate higher than 50% of clinical resolution with photodynamic therapy, beta-carotene, lycopene, or vitamin A. Few studies reported rates of recurrence from 5 to 67% and of malignant transformation from 8 to 23%. There is a lack of randomized clinical trials that assess the effectiveness of nonsurgical treatment of OL. At this time, randomized controlled trials for nonsurgical treatment of OL demonstrate no evidence of effective treatment in preventing malignant transformation and recurrence. It reinforces that even after clinical resolution, OL should be regularly followed.http://dx.doi.org/10.1155/2010/186018 |
| spellingShingle | Adriana Spinola Ribeiro Patrícia Ribeiro Salles Tarcília Aparecida da Silva Ricardo Alves Mesquita A Review of the Nonsurgical Treatment of Oral Leukoplakia International Journal of Dentistry |
| title | A Review of the Nonsurgical Treatment of Oral Leukoplakia |
| title_full | A Review of the Nonsurgical Treatment of Oral Leukoplakia |
| title_fullStr | A Review of the Nonsurgical Treatment of Oral Leukoplakia |
| title_full_unstemmed | A Review of the Nonsurgical Treatment of Oral Leukoplakia |
| title_short | A Review of the Nonsurgical Treatment of Oral Leukoplakia |
| title_sort | review of the nonsurgical treatment of oral leukoplakia |
| url | http://dx.doi.org/10.1155/2010/186018 |
| work_keys_str_mv | AT adrianaspinolaribeiro areviewofthenonsurgicaltreatmentoforalleukoplakia AT patriciaribeirosalles areviewofthenonsurgicaltreatmentoforalleukoplakia AT tarciliaaparecidadasilva areviewofthenonsurgicaltreatmentoforalleukoplakia AT ricardoalvesmesquita areviewofthenonsurgicaltreatmentoforalleukoplakia AT adrianaspinolaribeiro reviewofthenonsurgicaltreatmentoforalleukoplakia AT patriciaribeirosalles reviewofthenonsurgicaltreatmentoforalleukoplakia AT tarciliaaparecidadasilva reviewofthenonsurgicaltreatmentoforalleukoplakia AT ricardoalvesmesquita reviewofthenonsurgicaltreatmentoforalleukoplakia |