Association between chronic fatigue syndrome/myalgic encephalomyelitis and cardiovascular disease
Abstract Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a medical condition characterized by severe and prolonged fatigue that is not relieved by rest or attributed to any underlying medical or psychological condition. Individuals with CFS/ME are considered to have an increased ri...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86609-4 |
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| author | Mawulorm K. I. Denu Ritika Revoori Cherita Eghan Fredrick Larbi Kwapong Andrew Hillman Cornelius A. Normeshie Kofi Poku Berko Emily L. Aidoo Maame Araba E. Buadu |
| author_facet | Mawulorm K. I. Denu Ritika Revoori Cherita Eghan Fredrick Larbi Kwapong Andrew Hillman Cornelius A. Normeshie Kofi Poku Berko Emily L. Aidoo Maame Araba E. Buadu |
| author_sort | Mawulorm K. I. Denu |
| collection | DOAJ |
| description | Abstract Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a medical condition characterized by severe and prolonged fatigue that is not relieved by rest or attributed to any underlying medical or psychological condition. Individuals with CFS/ME are considered to have an increased risk of a wide range of comorbid conditions, including cardiovascular disease (CVD). The association between CFS/ME and CVD is not fully understood. To determine the prevalence of CFS/ME in a sample population and examine its association with CVD. Weighted sample size data of 114,834 was analyzed from the 2021–2022 national health interview survey (NHIS). Information on sociodemographic factors, CVD risk factors, and history of CFS/ME and CVD were collected. Multivariable logistic regression model was used to determine the association between CFS/ME and CVD, adjusting for traditional CVD risk factors (age, sex, race, hypertension, diabetes, dyslipidemia, smoking, and body mass index (BMI). Median age of participants was 53 years, and majority of participants were female (53.9%). Prevalence of CFS/ME was 1.2%. A history of CFS/ME was significantly associated with CVD (aOR 3.26, 95%CI 2.85, 3.72, p-value: <0.001) after adjusting for traditional CVD risk factors. A history of CFS/ME was independently associated with CVD after adjusting for traditional CVD risk factors. Patients with CFS/ME need close evaluation for CVD. Further studies are needed to better understand the relationship between CFS/ME and CVD. |
| format | Article |
| id | doaj-art-e7f988eea69b48dfa7f607c794ef77ef |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-e7f988eea69b48dfa7f607c794ef77ef2025-01-26T12:26:52ZengNature PortfolioScientific Reports2045-23222025-01-011511710.1038/s41598-025-86609-4Association between chronic fatigue syndrome/myalgic encephalomyelitis and cardiovascular diseaseMawulorm K. I. Denu0Ritika Revoori1Cherita Eghan2Fredrick Larbi Kwapong3Andrew Hillman4Cornelius A. Normeshie5Kofi Poku Berko6Emily L. Aidoo7Maame Araba E. Buadu8Division of Cardiovascular Medicine, University of Massachusetts Medical SchoolDivision of Cardiovascular Medicine, University of Massachusetts Medical SchoolDepartment of Medicine, Brigham and Women’s HospitalDepartment of Medicine, Beth Israel Deaconess Medical CenterDepartment of Radiology, Baylor College of MedicineDepartment of Family Medicine, University of Virginia Medical SchoolDepartment of Medicine, Korle Bu Teaching HospitalDepartment of Medicine, Beth Israel Deaconess Medical CenterDepartment of Medicine, Massachusetts General HospitalAbstract Chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a medical condition characterized by severe and prolonged fatigue that is not relieved by rest or attributed to any underlying medical or psychological condition. Individuals with CFS/ME are considered to have an increased risk of a wide range of comorbid conditions, including cardiovascular disease (CVD). The association between CFS/ME and CVD is not fully understood. To determine the prevalence of CFS/ME in a sample population and examine its association with CVD. Weighted sample size data of 114,834 was analyzed from the 2021–2022 national health interview survey (NHIS). Information on sociodemographic factors, CVD risk factors, and history of CFS/ME and CVD were collected. Multivariable logistic regression model was used to determine the association between CFS/ME and CVD, adjusting for traditional CVD risk factors (age, sex, race, hypertension, diabetes, dyslipidemia, smoking, and body mass index (BMI). Median age of participants was 53 years, and majority of participants were female (53.9%). Prevalence of CFS/ME was 1.2%. A history of CFS/ME was significantly associated with CVD (aOR 3.26, 95%CI 2.85, 3.72, p-value: <0.001) after adjusting for traditional CVD risk factors. A history of CFS/ME was independently associated with CVD after adjusting for traditional CVD risk factors. Patients with CFS/ME need close evaluation for CVD. Further studies are needed to better understand the relationship between CFS/ME and CVD.https://doi.org/10.1038/s41598-025-86609-4Chronic fatigue syndromeMyalgic encephalomyelitisCardiovascular diseaseRisk factors |
| spellingShingle | Mawulorm K. I. Denu Ritika Revoori Cherita Eghan Fredrick Larbi Kwapong Andrew Hillman Cornelius A. Normeshie Kofi Poku Berko Emily L. Aidoo Maame Araba E. Buadu Association between chronic fatigue syndrome/myalgic encephalomyelitis and cardiovascular disease Scientific Reports Chronic fatigue syndrome Myalgic encephalomyelitis Cardiovascular disease Risk factors |
| title | Association between chronic fatigue syndrome/myalgic encephalomyelitis and cardiovascular disease |
| title_full | Association between chronic fatigue syndrome/myalgic encephalomyelitis and cardiovascular disease |
| title_fullStr | Association between chronic fatigue syndrome/myalgic encephalomyelitis and cardiovascular disease |
| title_full_unstemmed | Association between chronic fatigue syndrome/myalgic encephalomyelitis and cardiovascular disease |
| title_short | Association between chronic fatigue syndrome/myalgic encephalomyelitis and cardiovascular disease |
| title_sort | association between chronic fatigue syndrome myalgic encephalomyelitis and cardiovascular disease |
| topic | Chronic fatigue syndrome Myalgic encephalomyelitis Cardiovascular disease Risk factors |
| url | https://doi.org/10.1038/s41598-025-86609-4 |
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