Impact of underweight status on mortality in sepsis patients: a meta-analysis
ObjectiveThe evidence regarding the impact of underweight status on clinical outcomes in patients with sepsis are still scarce and controversial. We aimed at conducting a meta-analysis to evaluate the potential associations between underweight and the mortality rate among sepsis patients.MethodsA co...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1549709/full |
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| author | Jiaan Chen Fan Zhang Li Liang Xuming Pan Jiancheng Zhang Guangjun Jin |
| author_facet | Jiaan Chen Fan Zhang Li Liang Xuming Pan Jiancheng Zhang Guangjun Jin |
| author_sort | Jiaan Chen |
| collection | DOAJ |
| description | ObjectiveThe evidence regarding the impact of underweight status on clinical outcomes in patients with sepsis are still scarce and controversial. We aimed at conducting a meta-analysis to evaluate the potential associations between underweight and the mortality rate among sepsis patients.MethodsA comprehensive electronic search was performed in PubMed, Cochrane Library, Embase, and Web of Science databases. Odds ratios (ORs) or mean differences and 95% confidence intervals (CIs) were calculated using RevMan 5.3.ResultsA total of 58,348 patients (normal weight group: 49,084 patients; underweight group: 9,264 patients) from 23 studies were included in this meta-analysis. The results indicated that the in-hospital mortality (OR, 1.28; 95% CI, 1.21, 1.35; heterogeneity: I2 = 21%, P = 0.21), 28-day mortality (OR, 1.54; 95% CI, 1.26, 1.88; heterogeneity: I2 = 74%, P < 0.0001) and 1-year mortality (OR, 1.78; 95% CI, 1.58, 2.00; heterogeneity: I2 = 41%, P = 0.17) of underweight patients were significantly higher than those of normal weight patients. However, there was no significant difference in length of hospital stay or intensive care unit length of stay between underweight patients and normal-weight patients.ConclusionUnderweight is associated with increased mortality in patients with sepsis. Physicians should pay more attention to the management of underweight sepsis patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=631417, identifier CRD42025631417. |
| format | Article |
| id | doaj-art-e7f91054ceb64f19b8de1f7f8793612d |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-e7f91054ceb64f19b8de1f7f8793612d2025-02-06T05:21:55ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-02-011210.3389/fmed.2025.15497091549709Impact of underweight status on mortality in sepsis patients: a meta-analysisJiaan Chen0Fan Zhang1Li Liang2Xuming Pan3Jiancheng Zhang4Guangjun Jin5Department of Clinical Medicine, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Clinical Medicine, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Clinical Medicine, The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaDepartment of Emergency, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaObjectiveThe evidence regarding the impact of underweight status on clinical outcomes in patients with sepsis are still scarce and controversial. We aimed at conducting a meta-analysis to evaluate the potential associations between underweight and the mortality rate among sepsis patients.MethodsA comprehensive electronic search was performed in PubMed, Cochrane Library, Embase, and Web of Science databases. Odds ratios (ORs) or mean differences and 95% confidence intervals (CIs) were calculated using RevMan 5.3.ResultsA total of 58,348 patients (normal weight group: 49,084 patients; underweight group: 9,264 patients) from 23 studies were included in this meta-analysis. The results indicated that the in-hospital mortality (OR, 1.28; 95% CI, 1.21, 1.35; heterogeneity: I2 = 21%, P = 0.21), 28-day mortality (OR, 1.54; 95% CI, 1.26, 1.88; heterogeneity: I2 = 74%, P < 0.0001) and 1-year mortality (OR, 1.78; 95% CI, 1.58, 2.00; heterogeneity: I2 = 41%, P = 0.17) of underweight patients were significantly higher than those of normal weight patients. However, there was no significant difference in length of hospital stay or intensive care unit length of stay between underweight patients and normal-weight patients.ConclusionUnderweight is associated with increased mortality in patients with sepsis. Physicians should pay more attention to the management of underweight sepsis patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=631417, identifier CRD42025631417.https://www.frontiersin.org/articles/10.3389/fmed.2025.1549709/full1-year mortalityin-hospital mortalitymeta-analysissepsisunderweight |
| spellingShingle | Jiaan Chen Fan Zhang Li Liang Xuming Pan Jiancheng Zhang Guangjun Jin Impact of underweight status on mortality in sepsis patients: a meta-analysis Frontiers in Medicine 1-year mortality in-hospital mortality meta-analysis sepsis underweight |
| title | Impact of underweight status on mortality in sepsis patients: a meta-analysis |
| title_full | Impact of underweight status on mortality in sepsis patients: a meta-analysis |
| title_fullStr | Impact of underweight status on mortality in sepsis patients: a meta-analysis |
| title_full_unstemmed | Impact of underweight status on mortality in sepsis patients: a meta-analysis |
| title_short | Impact of underweight status on mortality in sepsis patients: a meta-analysis |
| title_sort | impact of underweight status on mortality in sepsis patients a meta analysis |
| topic | 1-year mortality in-hospital mortality meta-analysis sepsis underweight |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1549709/full |
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