Endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complications
Aim. То assess endothelial function (EF) and lipid peroxidation (LPO) in patients with arterial hypertension (AH) and its cerebral complications.Material and methods. In total, 49 patients with ischemic stroke (IS), 37 patients with uncomplicated essentialAH (EAH) and 25 blood donors as controls wer...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«SILICEA-POLIGRAF» LLC
2009-04-01
|
| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1721 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850028167042957312 |
|---|---|
| author | M. V. Kazak T. S. Romanenko M. G. Omelyanenko A. V. Lebedeva I. K. Tomilova V. N. Vyatkin A. V. Kontsevaya |
| author_facet | M. V. Kazak T. S. Romanenko M. G. Omelyanenko A. V. Lebedeva I. K. Tomilova V. N. Vyatkin A. V. Kontsevaya |
| author_sort | M. V. Kazak |
| collection | DOAJ |
| description | Aim. То assess endothelial function (EF) and lipid peroxidation (LPO) in patients with arterial hypertension (AH) and its cerebral complications.Material and methods. In total, 49 patients with ischemic stroke (IS), 37 patients with uncomplicated essentialAH (EAH) and 25 blood donors as controls were examined. NO concentration (its stable metabolites, nitrates and nitrites) was measured by Griss method; citrulline (C) and malonic dialdehyde (MDA) levels were assessed with photocolorimetric method. Desquamated endotheliocytes (DE) were counted according to the method by J. Hladovec. LPO and plasma antioxidant activity (AOA) were studied with biochemiluminescence analysis.Results. In IS patients, NO and C concentrations were lowerthan inAH patients and controls, while DE numbers were higher in the former. These parameters were combined into one factor, “integral index of endothelial dysfunction” (IIED), with values of -0,86±0,19, 0,12±0,09, and 1,21±0,23 units in patients with IS, AH and in controls, respectively (p<0,005). LPO intensity was higher in IS individuals than in the controls; the same was true for MDA levels. AOA in IS subjects was similar to that in the control group. IIED was significantly correlated with LPO intensity and MDA concentration in IS patients.Conclusion. UncomplicatedAH was characterised by compensated endothelial dysfunction, while NO-endothelium system was decompensated in stroke. IIED parameter, representing EF in general, encompassed NO and C concentrations as well as DE count. In stroke patients, LPO activation was not associated with compensatory increase in AOA Endothelial dysfunction and LPO were strongly correlated. |
| format | Article |
| id | doaj-art-e7f83eac58314e85bc770a3b4209bbba |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2009-04-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-e7f83eac58314e85bc770a3b4209bbba2025-08-20T02:59:54Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252009-04-018228321439Endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complicationsM. V. Kazak0T. S. Romanenko1M. G. Omelyanenko2A. V. Lebedeva3I. K. Tomilova4V. N. Vyatkin5A. V. Kontsevaya6Ivanovo State Medical AcademyIvanovo State Medical AcademyIvanovo State Medical AcademyIvanovo State Medical AcademyIvanovo State Medical AcademyIvanovo Region Clinical HospitalState Research Centre for Preventive Medicine, Federal Agency on High Medical TechnologiesAim. То assess endothelial function (EF) and lipid peroxidation (LPO) in patients with arterial hypertension (AH) and its cerebral complications.Material and methods. In total, 49 patients with ischemic stroke (IS), 37 patients with uncomplicated essentialAH (EAH) and 25 blood donors as controls were examined. NO concentration (its stable metabolites, nitrates and nitrites) was measured by Griss method; citrulline (C) and malonic dialdehyde (MDA) levels were assessed with photocolorimetric method. Desquamated endotheliocytes (DE) were counted according to the method by J. Hladovec. LPO and plasma antioxidant activity (AOA) were studied with biochemiluminescence analysis.Results. In IS patients, NO and C concentrations were lowerthan inAH patients and controls, while DE numbers were higher in the former. These parameters were combined into one factor, “integral index of endothelial dysfunction” (IIED), with values of -0,86±0,19, 0,12±0,09, and 1,21±0,23 units in patients with IS, AH and in controls, respectively (p<0,005). LPO intensity was higher in IS individuals than in the controls; the same was true for MDA levels. AOA in IS subjects was similar to that in the control group. IIED was significantly correlated with LPO intensity and MDA concentration in IS patients.Conclusion. UncomplicatedAH was characterised by compensated endothelial dysfunction, while NO-endothelium system was decompensated in stroke. IIED parameter, representing EF in general, encompassed NO and C concentrations as well as DE count. In stroke patients, LPO activation was not associated with compensatory increase in AOA Endothelial dysfunction and LPO were strongly correlated.https://cardiovascular.elpub.ru/jour/article/view/1721endothelial dysfunctionlipid peroxidationarterial hypertensionischemic stroke |
| spellingShingle | M. V. Kazak T. S. Romanenko M. G. Omelyanenko A. V. Lebedeva I. K. Tomilova V. N. Vyatkin A. V. Kontsevaya Endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complications Кардиоваскулярная терапия и профилактика endothelial dysfunction lipid peroxidation arterial hypertension ischemic stroke |
| title | Endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complications |
| title_full | Endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complications |
| title_fullStr | Endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complications |
| title_full_unstemmed | Endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complications |
| title_short | Endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complications |
| title_sort | endothelial function and lipid peroxidation in patients with arterial hypertension and its cerebral complications |
| topic | endothelial dysfunction lipid peroxidation arterial hypertension ischemic stroke |
| url | https://cardiovascular.elpub.ru/jour/article/view/1721 |
| work_keys_str_mv | AT mvkazak endothelialfunctionandlipidperoxidationinpatientswitharterialhypertensionanditscerebralcomplications AT tsromanenko endothelialfunctionandlipidperoxidationinpatientswitharterialhypertensionanditscerebralcomplications AT mgomelyanenko endothelialfunctionandlipidperoxidationinpatientswitharterialhypertensionanditscerebralcomplications AT avlebedeva endothelialfunctionandlipidperoxidationinpatientswitharterialhypertensionanditscerebralcomplications AT iktomilova endothelialfunctionandlipidperoxidationinpatientswitharterialhypertensionanditscerebralcomplications AT vnvyatkin endothelialfunctionandlipidperoxidationinpatientswitharterialhypertensionanditscerebralcomplications AT avkontsevaya endothelialfunctionandlipidperoxidationinpatientswitharterialhypertensionanditscerebralcomplications |