Advanced NGS analysis of cell-free tumor DNA supports clonal relation to primary high-grade B-cell lymphoma lesion and CNS relapse despite MRI negativity

Advanced NGS analysis of cell-free tumor DNA supports clonal relation to primary high-grade B-cell lymphoma lesion and CNS relapse despite MRI negativity

Abstract High-grade B-cell lymphomas (HGBCLs) are aggressive blood cancers with a severe disease course, especially when the central nervous system (CNS) is involved. Standard histological examination depends on tissue availability and is currently supplemented with molecular tests, as the status of...

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Main Authors: Veronika Navrkalova, Andrea Mareckova, Jakub Porc, Samuel Hricko, Viera Hrabcakova, Jarmila Kissova, Sona Kundova, Marie Jarosova, Sarka Pospisilova, Jana Kotaskova, Andrea Janikova
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Diagnostic Pathology
Subjects:
High-grade B-cell lymphoma
Central nervous system involvement
Cell-free DNA
Next-generation sequencing
Integrative diagnostics
Online Access:https://doi.org/10.1186/s13000-025-01609-2
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