Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging
Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition. Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unkno...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.27 |
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| author | Emanuele Marzetti Giuseppe Privitera Vincenzo Simili Stephanie E. Wohlgemuth Lorenzo Aulisa Marco Pahor Christiaan Leeuwenburgh |
| author_facet | Emanuele Marzetti Giuseppe Privitera Vincenzo Simili Stephanie E. Wohlgemuth Lorenzo Aulisa Marco Pahor Christiaan Leeuwenburgh |
| author_sort | Emanuele Marzetti |
| collection | DOAJ |
| description | Sarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition. Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unknown. An altered regulation of myocyte apoptosis has recently emerged as a possible contributor to the pathogenesis of sarcopenia. Studies in animal models have shown that the severity of skeletal muscle apoptosis increases over the course of aging and correlates with the degree of muscle mass and strength decline. Several apoptotic pathways are operative in aged muscles, with the mitochondria- and TNF-α-mediated pathways likely being the most relevant to sarcopenia. However, despite the growing number of studies on the subject, a definite mechanistic link between myocyte apoptosis and age-related muscle atrophy has not yet been established. Furthermore, the evidence on the role played by apoptosis in human sarcopenia is still sparse. Clearly, further research is required to better define the involvement of myocyte apoptosis in the pathogenesis of muscle loss at advanced age. This knowledge will likely help in the design of more effective therapeutic strategies to preserve muscle mass into old age, thus fostering independence of the elderly population and reducing the socioeconomic burden associated with sarcopenia. |
| format | Article |
| id | doaj-art-e7f4b42e57614a28aced6b617606d9bc |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e7f4b42e57614a28aced6b617606d9bc2025-08-20T03:21:02ZengWileyThe Scientific World Journal1537-744X2010-01-011034034910.1100/tsw.2010.27Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of AgingEmanuele Marzetti0Giuseppe Privitera1Vincenzo Simili2Stephanie E. Wohlgemuth3Lorenzo Aulisa4Marco Pahor5Christiaan Leeuwenburgh6Department of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL, USADepartment of Anesthesiology, Catholic University of the Sacred Heart, Rome, ItalyDepartment of Anesthesiology, Catholic University of the Sacred Heart, Rome, ItalyDepartment of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL, USADepartment of Orthopaedics and Traumatology, Catholic University of the Sacred Heart, Rome, ItalyDepartment of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL, USADepartment of Aging and Geriatric Research, Institute on Aging, Division of Biology of Aging, University of Florida, Gainesville, FL, USASarcopenia, the age-related decline in muscle mass and function, represents a significant health issue due to the high prevalence of frailty and disability associated with this condition. Nevertheless, the cellular mechanisms responsible for the loss of muscle mass in old age are still largely unknown. An altered regulation of myocyte apoptosis has recently emerged as a possible contributor to the pathogenesis of sarcopenia. Studies in animal models have shown that the severity of skeletal muscle apoptosis increases over the course of aging and correlates with the degree of muscle mass and strength decline. Several apoptotic pathways are operative in aged muscles, with the mitochondria- and TNF-α-mediated pathways likely being the most relevant to sarcopenia. However, despite the growing number of studies on the subject, a definite mechanistic link between myocyte apoptosis and age-related muscle atrophy has not yet been established. Furthermore, the evidence on the role played by apoptosis in human sarcopenia is still sparse. Clearly, further research is required to better define the involvement of myocyte apoptosis in the pathogenesis of muscle loss at advanced age. This knowledge will likely help in the design of more effective therapeutic strategies to preserve muscle mass into old age, thus fostering independence of the elderly population and reducing the socioeconomic burden associated with sarcopenia.http://dx.doi.org/10.1100/tsw.2010.27 |
| spellingShingle | Emanuele Marzetti Giuseppe Privitera Vincenzo Simili Stephanie E. Wohlgemuth Lorenzo Aulisa Marco Pahor Christiaan Leeuwenburgh Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging The Scientific World Journal |
| title | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
| title_full | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
| title_fullStr | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
| title_full_unstemmed | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
| title_short | Multiple Pathways to the Same End: Mechanisms of Myonuclear Apoptosis in Sarcopenia of Aging |
| title_sort | multiple pathways to the same end mechanisms of myonuclear apoptosis in sarcopenia of aging |
| url | http://dx.doi.org/10.1100/tsw.2010.27 |
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