Functional role of pyruvate kinase M2 in cell cycle arrest and extracellular matrix secretion of renal tubular epithelial cell induced by transforming growth factor-β1

Functional role of pyruvate kinase M2 in cell cycle arrest and extracellular matrix secretion of renal tubular epithelial cell induced by transforming growth factor-β1

Objective To explore the functional role of pyruvate kinase M2（PKM 2） in cell cycle arrest and extracellular matrix secretion of renal tubular epithelial cell induced by transforming growth factor-β1（TGF-β1）.Methods HK-2 cells were stimulated by TGF-β1 for establishing an in vitro model of renal tub...

Full description

Saved in:

Bibliographic Details
Main Authors:	Wu Hong-luan, An Ning, Chen Xiao-cui, Pang Hao-wen, Yang Chen, Liu Hua-feng
Format:	Article
Language:	zho
Published:	Editorial Department of Journal of Clinical Nephrology 2021-01-01
Series:	Linchuang shenzangbing zazhi
Subjects:	Renal tubular epithelial cell Pyruvate kinase M2 TGF-β1 Cell cycle arrest Extracellular matrix secretion
Online Access:	http://www.lcszb.com/thesisDetails?columnId=57902018&Fpath=home&index=0
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Effect of transforming growth factor-β (TGF-β) on gene expression profile of human tubular epithelial cells and bioinformatic analysis
by: WANG Guo-ping, et al.
Published: (2019-01-01)

Pyruvate kinase M2 modulates mitochondrial dynamics and EMT in alveolar epithelial cells during sepsis-associated pulmonary fibrosis
by: Jinhua Feng, et al.
Published: (2025-02-01)

Effect of calcitriol on up-regulated expression of renin in renal tubular epithelial cells induced by high glucose
by: HAO Tian-ya, et al.
Published: (2016-01-01)

ARA290 inhibits apoptosis of renal tubular epithelial cells in diabetic rats
by: DANG Jian-zhong, et al.
Published: (2019-01-01)

Development of a cell-based target engagement assay for pyruvate dehydrogenase kinase
by: Mya D. Gough, et al.
Published: (2025-04-01)

Effects of Pyruvate Kinase Phosphorylation and Acetylation on Its Activity and Structure
by: Xiaolan HUANG, et al.
Published: (2025-09-01)

Single-Cell Profiling of Tubular Epithelial Cells in Adaptive State in the Urine Sediment of Patients With Early and Advanced Diabetic Kidney Disease
by: Dongzhao Ma, et al.
Published: (2025-03-01)

DNA-PKcs participates in the repair of renal tubular epithelial cell injury
by: Dan Feng, et al.
Published: (2025-12-01)

Proteinuria and proximal tubular epithelial cells: correlation between immunofluorescence, histology, and degree of proteinuria
by: Maria Bernadette CY Chow, et al.
Published: (2024-10-01)

Role of autophagy in lipid aggregation in lipid-induced renal tubular epithelial damage
by: WANG Rui, et al.
Published: (2016-01-01)

DPP8 and DPP9 promote tubular epithelial cell ferroptosis in acute kidney injury
by: Kexin Guan, et al.
Published: (2025-07-01)

Elevation of ISG15 promotes diabetic kidney disease by modulating renal tubular epithelial cell pyroptosis
by: Lingzhi Huang, et al.
Published: (2025-06-01)

Immunoassay for pyruvate kinase M1/2 as an Alzheimer’s biomarker in CSF
by: de Geus Matthijs B., et al.
Published: (2025-07-01)

The protective effect of kaempferol on high glucose-stimulated renal tubular epithelial cells
by: Xiao-Cui Jiao, et al.
Published: (2025-08-01)

Homocysteine induces ferroptosis in renal tubular epithelial cells via β-catenin/GPX4 signaling pathway
by: Yanping Lei, et al.
Published: (2025-07-01)

Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain
by: Afag M Rashidova
Published: (2018-09-01)

Inhibition of Caspase-3/GSDME Pathway-Mediated Pyroptosis of Renal Tubular Epithelial Cells by Dagliflozin in the Pathogenesis of Diabetic Kidney Disease and Study of Its Mechanism
by: Jiang H, et al.
Published: (2025-06-01)

Allosteric regulation of pyruvate kinase enables efficient and robust gluconeogenesis by preventing metabolic conflicts and carbon overflow
by: Fukang She, et al.
Published: (2025-02-01)

Effect of apigenin regulating lncRNA MEG8 on high glucose-induced injury of human renal tubular epithelial cells
by: Lu Di, et al.
Published: (2022-01-01)

Contents of plasma М2-pyruvate kinase (M2-РК) in patients with inflammatory bowel diseases
by: Ye. A. Konovich, et al.
Published: (2010-11-01)

Effects and mechanisms of telmisartan on adiponectin receptors in rat renal proximal tubular epithelial cells induced by high glucose
by: BU Xi, et al.
Published: (2019-01-01)

Oxoglutarate dehydrogenase-L regulates mitochondrial metabolism reprogramming of renal tubular epithelial cells to alleviate renal fibrosis
by: YANG Yingxian, et al.
Published: (2025-06-01)

Pyruvate kinase directly generates GTP in glycolysis, supporting growth and contributing to guanosine toxicity
by: Fukang She, et al.
Published: (2025-04-01)

Mortality among US veterans with a physician-documented diagnosis of pyruvate kinase deficiency
by: Erin Zagadailov, et al.
Published: (2024-12-01)

Flow-Cytometric Quantification of Urine Kidney Epithelial Cells Specifically Reflects Tubular Damage in Acute Kidney Diseases
by: Leonie Wagner, et al.
Published: (2025-04-01)

Inhibition of Axl attenuates acute kidney injury by alleviating inflammation via SOCS3 downregulation in tubular epithelial cells
by: Xin Kang, et al.
Published: (2025-07-01)

Mechanism of inhibiting renal tubular epithelial cell transformation by silencing dendritic cell CRR7 receptor
by: Gao Ting-ting, et al.
Published: (2021-01-01)

Ginsenoside Rb1 alleviates renal tubular epithelial cell injury in diabetic kidney disease by inhibiting the aldose reductase activity
by: Wang Meng-jing, et al.
Published: (2025-07-01)

Effects of miR-4429/NQO1 on high glucose-induced renal tubular epithelial injury and inflammatory factor secretion
by: ZHOU Yan, et al.
Published: (2020-01-01)

ACSF2-PGK1 interaction promotes ferroptosis in renal tubular epithelial cells of diabetic nephropathy by regulating Keap1/Nrf2 signaling
by: Xinran Liu, et al.
Published: (2025-12-01)

Protective effect of CoCl<sub>2</sub> on vancomycin-induced apoptosis of human renal tubular epithelial cells
by: Liu Yuan, et al.
Published: (2025-05-01)

Caffeic acid phenethyl ester protects renal tubular epithelial cells against ferroptosis in diabetic kidney disease via restoring PINK1-mediated mitophagy
by: Ying Lu, et al.
Published: (2025-07-01)

Renal tubular epithelial cell related partial epithelial-mesenchymal transition in AAⅠ induced renal fibrosis via Wnt7b/β-catenin signaling
by: Yi-Fan Wang, et al.
Published: (2025-05-01)

Total cornus officinalis glycosides inhibit high glucose-induced cell apoptosis and oxidative damage of human renal tubular epithelial cell line HK-2
by: ZHANG Xiaodong, LI Wendong, CHEN Jinghe, ZHANG Yanqin
Published: (2024-12-01)

Effect of angiotensin Ⅱ type 1 receptor on injury of renal tubular epithelial cells induced by high glucose
by: ZHA Dong-qing, et al.
Published: (2018-01-01)

The novelty of profilin 2 in regulating pyruvate kinase M2 nuclear translocation and promoting tumor angiogenesis in lung adenocarcinoma
by: Xiaohui Du, et al.
Published: (2025-05-01)

Deletion of Pyruvate Carboxylase in Tubular Epithelial Cell Promotes Renal Fibrosis by Regulating SQOR/cGAS/STING‐Mediated Glycolysis
by: Hao Huang, et al.
Published: (2025-04-01)

Effects of osthole on renal tubular epithelial cell injury and Nrf2/HO-1 signal pathway induced by high glucose，hypoxia and reoxygenation
by: Han Ming-yue, et al.
Published: (2022-05-01)

Effects of chikusetsu saponin Ⅳa on high glucose-induced human renal tubular epithelial cell injury through regulating circEIF4G2/miR-379-5p
by: Qin Li, et al.
Published: (2022-06-01)

Jumi extract lowered the expression of inflammatory and fibrotic components in human renal tubular epithelial cells induced by high glucose through inhibiting long noncoding RNA RMRP gene
by: Cheng Tao, et al.
Published: (2022-02-01)