Mechanisms of Allergic Inflammation
Genetic predisposition and environmental instructions tune thresholds for activation, effector functions and life span of T cells, other inflammatory cells and resident tissue cells. Defects in apoptosis and peripheral tolerance in T cells define different allergic phenotypes. High IFN-g-producing a...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2009-06-01
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| Series: | Güncel Pediatri |
| Subjects: | |
| Online Access: | http://www.guncelpediatri.com/yazilar.asp?yaziid=885&sayiid= |
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| Summary: | Genetic predisposition and environmental instructions tune thresholds for activation, effector functions and life span of T cells, other inflammatory cells and resident tissue cells. Defects in apoptosis and peripheral tolerance in T cells define different allergic phenotypes. High IFN-g-producing activated allergen-specific T cells predominantly undergo apoptosis in the circulation, skewing the immune response to surviving Th2 cells in atopic diseases. In affected tissues, these cells switch on effector cytokines, induce activation and apoptosis of epithelial cells. On the other hand, in monoallergic non-atopic individuals disturbed balance toward allergen-specific T helper 2 cells instead of T regulatory 1 cells characterize the T cell response. (Journal of Current Pediatrics 2009; 7: 24-30) |
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| ISSN: | 1304-9054 |