The effect of workplace environment on coal miners' gut microbiota in a mouse model
The coal mine workplace environment is a significant factor in inducing occupational health issues, such as intestinal dysfunction in coal miners. However, the mechanism by which the coal mine workplace environment induces intestinal dysfunction is still unclear. Therefore, we applied the Coal Mine...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1453798/full |
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| author | Lei Li Lei Li Mei Zhi Mei Zhi Siwei Wang Siwei Wang Siwei Wang Jun Deng Jun Deng Qing Cai Dayun Feng |
| author_facet | Lei Li Lei Li Mei Zhi Mei Zhi Siwei Wang Siwei Wang Siwei Wang Jun Deng Jun Deng Qing Cai Dayun Feng |
| author_sort | Lei Li |
| collection | DOAJ |
| description | The coal mine workplace environment is a significant factor in inducing occupational health issues, such as intestinal dysfunction in coal miners. However, the mechanism by which the coal mine workplace environment induces intestinal dysfunction is still unclear. Therefore, we applied the Coal Mine Workplace Environment Biological Simulation (CEBS) model which was previously constructed to detect the intestinal pathological manifestations and changes in the gut microbiota of mice from the perspectives of intestinal function, tissue morphology, and cell molecules. CEBS mice showed increased fecal water content, shortened colon length, significant activation of MPO+ and CD11b+ numbers, and significant changes in IL-1b, IL-6, and IL-12 expression levels. In addition, we also found an imbalance in the proportions of Firmicutes, Bacteroidetes, Lactobacillus, and Parabacteroides in CEBS mice, resulting in significant changes in gut microbial diversity. After intervention with compound probiotics, the intestinal function of CEBS + Mix mice was improved and inflammation levels were reduced. Results indicated that stress in the coal mine workplace environment can lead to intestinal dysfunction and inflammatory damage of the colon and use of compound probiotics can improve intestinal dysfunction in CBES mice. In our study, we revealed that there is a correlation between coal mine workplace environment and diversity disorders of gut microbiota. This discovery has enhanced the relevant theories on the causes of intestinal dysfunction in coal miners and has suggested a new approach to intervention. |
| format | Article |
| id | doaj-art-e7ed86c6b79f4353a4e907828687772e |
| institution | DOAJ |
| issn | 1664-302X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj-art-e7ed86c6b79f4353a4e907828687772e2025-08-20T02:50:02ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2024-12-011510.3389/fmicb.2024.14537981453798The effect of workplace environment on coal miners' gut microbiota in a mouse modelLei Li0Lei Li1Mei Zhi2Mei Zhi3Siwei Wang4Siwei Wang5Siwei Wang6Jun Deng7Jun Deng8Qing Cai9Dayun Feng10School of Safety Science and Engineering, Xi'an University of Science and Technology, Xi'an, ChinaKey Laboratory for Prevention and Control of Coal Fires in Shaanxi Province, Xi'an, ChinaSchool of Safety Science and Engineering, Xi'an University of Science and Technology, Xi'an, ChinaKey Laboratory for Prevention and Control of Coal Fires in Shaanxi Province, Xi'an, ChinaSchool of Safety Science and Engineering, Xi'an University of Science and Technology, Xi'an, ChinaKey Laboratory for Prevention and Control of Coal Fires in Shaanxi Province, Xi'an, ChinaSafety Supervision Department, Nanhai Department of Transportation, Foshan, ChinaSchool of Safety Science and Engineering, Xi'an University of Science and Technology, Xi'an, ChinaKey Laboratory for Prevention and Control of Coal Fires in Shaanxi Province, Xi'an, ChinaDepartment of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaDepartment of Neurosurgery and Institute for Functional Brain Disorders, Tangdu Hospital, Fourth Military Medical University, Xi'an, ChinaThe coal mine workplace environment is a significant factor in inducing occupational health issues, such as intestinal dysfunction in coal miners. However, the mechanism by which the coal mine workplace environment induces intestinal dysfunction is still unclear. Therefore, we applied the Coal Mine Workplace Environment Biological Simulation (CEBS) model which was previously constructed to detect the intestinal pathological manifestations and changes in the gut microbiota of mice from the perspectives of intestinal function, tissue morphology, and cell molecules. CEBS mice showed increased fecal water content, shortened colon length, significant activation of MPO+ and CD11b+ numbers, and significant changes in IL-1b, IL-6, and IL-12 expression levels. In addition, we also found an imbalance in the proportions of Firmicutes, Bacteroidetes, Lactobacillus, and Parabacteroides in CEBS mice, resulting in significant changes in gut microbial diversity. After intervention with compound probiotics, the intestinal function of CEBS + Mix mice was improved and inflammation levels were reduced. Results indicated that stress in the coal mine workplace environment can lead to intestinal dysfunction and inflammatory damage of the colon and use of compound probiotics can improve intestinal dysfunction in CBES mice. In our study, we revealed that there is a correlation between coal mine workplace environment and diversity disorders of gut microbiota. This discovery has enhanced the relevant theories on the causes of intestinal dysfunction in coal miners and has suggested a new approach to intervention.https://www.frontiersin.org/articles/10.3389/fmicb.2024.1453798/fullcoal mine workplace environmentintestinal dysfunctiongut microbiotacompound probioticsintervention |
| spellingShingle | Lei Li Lei Li Mei Zhi Mei Zhi Siwei Wang Siwei Wang Siwei Wang Jun Deng Jun Deng Qing Cai Dayun Feng The effect of workplace environment on coal miners' gut microbiota in a mouse model Frontiers in Microbiology coal mine workplace environment intestinal dysfunction gut microbiota compound probiotics intervention |
| title | The effect of workplace environment on coal miners' gut microbiota in a mouse model |
| title_full | The effect of workplace environment on coal miners' gut microbiota in a mouse model |
| title_fullStr | The effect of workplace environment on coal miners' gut microbiota in a mouse model |
| title_full_unstemmed | The effect of workplace environment on coal miners' gut microbiota in a mouse model |
| title_short | The effect of workplace environment on coal miners' gut microbiota in a mouse model |
| title_sort | effect of workplace environment on coal miners gut microbiota in a mouse model |
| topic | coal mine workplace environment intestinal dysfunction gut microbiota compound probiotics intervention |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2024.1453798/full |
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