Natural history of cutaneous human papillomavirus (HPV) infection in men: the HIM study.
Accumulating evidence suggests that cutaneous human papillomavirus (HPV) infection is associated with non-melanoma skin cancer (NMSC). Little is known about the natural history of cutaneous HPV. A sub-cohort of 209 men with no NMSC history, initially enrolled in the HPV infection in men (HIM) study,...
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| Format: | Article |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0104843 |
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| author | Shalaka S Hampras Anna R Giuliano Hui-Yi Lin Kate J Fisher Martha E Abrahamsen Bradley A Sirak Michelle R Iannacone Tarik Gheit Massimo Tommasino Dana E Rollison |
| author_facet | Shalaka S Hampras Anna R Giuliano Hui-Yi Lin Kate J Fisher Martha E Abrahamsen Bradley A Sirak Michelle R Iannacone Tarik Gheit Massimo Tommasino Dana E Rollison |
| author_sort | Shalaka S Hampras |
| collection | DOAJ |
| description | Accumulating evidence suggests that cutaneous human papillomavirus (HPV) infection is associated with non-melanoma skin cancer (NMSC). Little is known about the natural history of cutaneous HPV. A sub-cohort of 209 men with no NMSC history, initially enrolled in the HPV infection in men (HIM) study, were followed for a median of 12.6 months. Epidemiological data were collected through self-administered questionnaires. Cutaneous HPV DNA was measured in normal skin swabs (SS) and eyebrow hairs (EB) for 25 and 16 HPV types in genera β and γ, respectively. Any β HPV infection was more prevalent in SS (67.3%) compared to EB (56.5%, p = 0.04). Incidence in SS was higher than 20 per 1,000 person-months for HPV types 4, 5, 23, 38 and 76. Median duration of persistence of β and γ HPV infection was 8.6 and 6.1 months in EB, respectively, and 11.3 months and 6.3 months, in SS, respectively. Older age (>44 years vs. 18-30 years) was significantly associated with prevalent (SS OR = 3.0, 95% CI = 1.2-7.0) and persistent β HPV infection (EB OR = 6.1, 95% CI = 2.6-14.1). History of blistering sunburn was associated with prevalent (OR = 2.8, 95% CI = 1.3-5.8) and persistent (OR = 2.3, 95% CI = 1.2-4.6) β HPV infection in SS. Cutaneous HPV is highly prevalent in men, with age and blistering sunburn being significant risk factors for cutaneous β HPV infection. |
| format | Article |
| id | doaj-art-e7ea109715204572b78a70a466bcda1f |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e7ea109715204572b78a70a466bcda1f2025-08-20T02:34:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0199e10484310.1371/journal.pone.0104843Natural history of cutaneous human papillomavirus (HPV) infection in men: the HIM study.Shalaka S HamprasAnna R GiulianoHui-Yi LinKate J FisherMartha E AbrahamsenBradley A SirakMichelle R IannaconeTarik GheitMassimo TommasinoDana E RollisonAccumulating evidence suggests that cutaneous human papillomavirus (HPV) infection is associated with non-melanoma skin cancer (NMSC). Little is known about the natural history of cutaneous HPV. A sub-cohort of 209 men with no NMSC history, initially enrolled in the HPV infection in men (HIM) study, were followed for a median of 12.6 months. Epidemiological data were collected through self-administered questionnaires. Cutaneous HPV DNA was measured in normal skin swabs (SS) and eyebrow hairs (EB) for 25 and 16 HPV types in genera β and γ, respectively. Any β HPV infection was more prevalent in SS (67.3%) compared to EB (56.5%, p = 0.04). Incidence in SS was higher than 20 per 1,000 person-months for HPV types 4, 5, 23, 38 and 76. Median duration of persistence of β and γ HPV infection was 8.6 and 6.1 months in EB, respectively, and 11.3 months and 6.3 months, in SS, respectively. Older age (>44 years vs. 18-30 years) was significantly associated with prevalent (SS OR = 3.0, 95% CI = 1.2-7.0) and persistent β HPV infection (EB OR = 6.1, 95% CI = 2.6-14.1). History of blistering sunburn was associated with prevalent (OR = 2.8, 95% CI = 1.3-5.8) and persistent (OR = 2.3, 95% CI = 1.2-4.6) β HPV infection in SS. Cutaneous HPV is highly prevalent in men, with age and blistering sunburn being significant risk factors for cutaneous β HPV infection.https://doi.org/10.1371/journal.pone.0104843 |
| spellingShingle | Shalaka S Hampras Anna R Giuliano Hui-Yi Lin Kate J Fisher Martha E Abrahamsen Bradley A Sirak Michelle R Iannacone Tarik Gheit Massimo Tommasino Dana E Rollison Natural history of cutaneous human papillomavirus (HPV) infection in men: the HIM study. PLoS ONE |
| title | Natural history of cutaneous human papillomavirus (HPV) infection in men: the HIM study. |
| title_full | Natural history of cutaneous human papillomavirus (HPV) infection in men: the HIM study. |
| title_fullStr | Natural history of cutaneous human papillomavirus (HPV) infection in men: the HIM study. |
| title_full_unstemmed | Natural history of cutaneous human papillomavirus (HPV) infection in men: the HIM study. |
| title_short | Natural history of cutaneous human papillomavirus (HPV) infection in men: the HIM study. |
| title_sort | natural history of cutaneous human papillomavirus hpv infection in men the him study |
| url | https://doi.org/10.1371/journal.pone.0104843 |
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