Patterns of germline and somatic mutations in 16 genes associated with mismatch repair function or containing tandem repeat sequences

Patterns of germline and somatic mutations in 16 genes associated with mismatch repair function or containing tandem repeat sequences

Abstract Background We assumed that targeted next‐generation sequencing (NGS) of mismatch repair‐associated genes could improve the detection of driving mutations in colorectal cancers (CRC) with microsatellite instability (MSI) and microsatellite alterations at selected tetranucleotide repeats (EMA...

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Main Authors: Shih‐Ching Chang, Yuan‐Tzu Lan, Pei‐Ching Lin, Shung‐Haur Yang, Chien‐Hsing Lin, Wen‐Yi Liang, Wei‐Shone Chen, Jeng‐Kai Jiang, Jen‐Kou Lin
Format: Article
Language:English
Published: Wiley 2020-01-01
Series:Cancer Medicine
Subjects:
colorectal cancer
EMAST
MMR
MSI
mutation
Online Access:https://doi.org/10.1002/cam4.2702
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