Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study.
<h4>Objective</h4>To determine which of four Dixon image types [in-phase (IP), out-of-phase (OP), fat only (FO) and water-only (WO)] is most sensitive for detecting multiple myeloma (MM) focal lesions on whole body MRI (WB-MRI) images.<h4>Methods</h4>Thirty patients with clin...
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180562&type=printable |
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| author | Timothy J P Bray Saurabh Singh Arash Latifoltojar Kannan Rajesparan Farzana Rahman Priya Narayanan Sahar Naaseri Andre Lopes Alan Bainbridge Shonit Punwani Margaret A Hall-Craggs |
| author_facet | Timothy J P Bray Saurabh Singh Arash Latifoltojar Kannan Rajesparan Farzana Rahman Priya Narayanan Sahar Naaseri Andre Lopes Alan Bainbridge Shonit Punwani Margaret A Hall-Craggs |
| author_sort | Timothy J P Bray |
| collection | DOAJ |
| description | <h4>Objective</h4>To determine which of four Dixon image types [in-phase (IP), out-of-phase (OP), fat only (FO) and water-only (WO)] is most sensitive for detecting multiple myeloma (MM) focal lesions on whole body MRI (WB-MRI) images.<h4>Methods</h4>Thirty patients with clinically-suspected MM underwent WB-MRI at 3 Tesla. Unenhanced IP, OP, FO and WO Dixon images were generated and read by four radiologists. On each image type, each radiologist identified and labelled all visible myeloma lesions in the bony pelvis. Each identified lesion was compared with a reference standard consisting of pre- and post-contrast Dixon and diffusion weighted imaging (read by a further consultant radiologist) to determine whether the lesion was truly positive. Lesion count, true positives, sensitivity, and positive predictive value were compared across the four Dixon image types.<h4>Results</h4>Lesion count, true positives, sensitivity and confidence scores were all significantly higher on FO images than on IP images (p>0.05).<h4>Discussion</h4>FO images are more sensitive than other Dixon image types for MM focal lesions, and should be preferentially read by radiologists to improve diagnostic accuracy and reporting efficiency. |
| format | Article |
| id | doaj-art-e7e7a678581d4e7aa4e640e32c253f13 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-e7e7a678581d4e7aa4e640e32c253f132025-08-20T02:01:56ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01127e018056210.1371/journal.pone.0180562Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study.Timothy J P BraySaurabh SinghArash LatifoltojarKannan RajesparanFarzana RahmanPriya NarayananSahar NaaseriAndre LopesAlan BainbridgeShonit PunwaniMargaret A Hall-Craggs<h4>Objective</h4>To determine which of four Dixon image types [in-phase (IP), out-of-phase (OP), fat only (FO) and water-only (WO)] is most sensitive for detecting multiple myeloma (MM) focal lesions on whole body MRI (WB-MRI) images.<h4>Methods</h4>Thirty patients with clinically-suspected MM underwent WB-MRI at 3 Tesla. Unenhanced IP, OP, FO and WO Dixon images were generated and read by four radiologists. On each image type, each radiologist identified and labelled all visible myeloma lesions in the bony pelvis. Each identified lesion was compared with a reference standard consisting of pre- and post-contrast Dixon and diffusion weighted imaging (read by a further consultant radiologist) to determine whether the lesion was truly positive. Lesion count, true positives, sensitivity, and positive predictive value were compared across the four Dixon image types.<h4>Results</h4>Lesion count, true positives, sensitivity and confidence scores were all significantly higher on FO images than on IP images (p>0.05).<h4>Discussion</h4>FO images are more sensitive than other Dixon image types for MM focal lesions, and should be preferentially read by radiologists to improve diagnostic accuracy and reporting efficiency.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180562&type=printable |
| spellingShingle | Timothy J P Bray Saurabh Singh Arash Latifoltojar Kannan Rajesparan Farzana Rahman Priya Narayanan Sahar Naaseri Andre Lopes Alan Bainbridge Shonit Punwani Margaret A Hall-Craggs Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study. PLoS ONE |
| title | Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study. |
| title_full | Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study. |
| title_fullStr | Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study. |
| title_full_unstemmed | Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study. |
| title_short | Diagnostic utility of whole body Dixon MRI in multiple myeloma: A multi-reader study. |
| title_sort | diagnostic utility of whole body dixon mri in multiple myeloma a multi reader study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0180562&type=printable |
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