Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis
Abstract Background The association between red blood cell distribution width (RDW) and short- and long-term all-cause mortality in patients with acute pancreatitis (AP) and sepsis remains unclear. Methods Data were extracted from the MIMIC-IV database for patients diagnosed with AP and sepsis. The...
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2025-07-01
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| Online Access: | https://doi.org/10.1186/s12876-025-04167-5 |
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| author | Qingzhou Song Xuanlin Wu Firooz Ahmad Taheri Linghou Meng Wentao Wang Xianwei Mo |
| author_facet | Qingzhou Song Xuanlin Wu Firooz Ahmad Taheri Linghou Meng Wentao Wang Xianwei Mo |
| author_sort | Qingzhou Song |
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| description | Abstract Background The association between red blood cell distribution width (RDW) and short- and long-term all-cause mortality in patients with acute pancreatitis (AP) and sepsis remains unclear. Methods Data were extracted from the MIMIC-IV database for patients diagnosed with AP and sepsis. The primary research endpoints were all-cause mortality at 28, 90, and 365 days. Kaplan-Meier survival curve analysis, restricted cubic spline (RCS) receiver operating characteristic (ROC) curves, subgroup analysis, and Cox regression were employed to assess the association between RDW and mortality. Results A total of 759 patients with AP and sepsis were included. The all-cause mortality rates were 17.26%, 25.96%, and 31.49% at 28, 90, and 365 days, respectively. Cox regression analysis indicated that, after adjustment for covariates, elevated RDW was significantly associated with increased risk of mortality at 28, 90, and 365 days. The hazard ratios (HR) were 1.08 (95% CI: 1.02–1.14) for 28-day mortality, 1.12 (95% CI: 1.07–1.17) for 90-day mortality, and 1.13 (95% CI: 1.08–1.18) for 365-day mortality. The RCS analysis indicated a nonlinear relationship. Kaplan-Meier analysis demonstrated significantly higher mortality in the high-RDW group compared to the low-RDW group (p < 0.001). The area under the curve (AUC) for RDW was greater than that for BISAP and SIRS, but lower than the SOFA. Subgroup analyses showed no significant interactions between RDW and most subgroups. Conclusion Elevated RDW is independently associated with increased short- and long-term all-cause mortality in patients with AP and sepsis. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-e7e36f55683b444991d088a51ea351542025-08-20T04:03:06ZengBMCBMC Gastroenterology1471-230X2025-07-0125111410.1186/s12876-025-04167-5Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsisQingzhou Song0Xuanlin Wu1Firooz Ahmad Taheri2Linghou Meng3Wentao Wang4Xianwei Mo5Division of Colorectal & Anal Surgery, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer HospitalDepartment of Breast Surgery, Guangxi Medical University Cancer HospitalDivision of Colorectal & Anal Surgery, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer HospitalDivision of Colorectal & Anal Surgery, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer HospitalDivision of Colorectal & Anal Surgery, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer HospitalDivision of Colorectal & Anal Surgery, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer HospitalAbstract Background The association between red blood cell distribution width (RDW) and short- and long-term all-cause mortality in patients with acute pancreatitis (AP) and sepsis remains unclear. Methods Data were extracted from the MIMIC-IV database for patients diagnosed with AP and sepsis. The primary research endpoints were all-cause mortality at 28, 90, and 365 days. Kaplan-Meier survival curve analysis, restricted cubic spline (RCS) receiver operating characteristic (ROC) curves, subgroup analysis, and Cox regression were employed to assess the association between RDW and mortality. Results A total of 759 patients with AP and sepsis were included. The all-cause mortality rates were 17.26%, 25.96%, and 31.49% at 28, 90, and 365 days, respectively. Cox regression analysis indicated that, after adjustment for covariates, elevated RDW was significantly associated with increased risk of mortality at 28, 90, and 365 days. The hazard ratios (HR) were 1.08 (95% CI: 1.02–1.14) for 28-day mortality, 1.12 (95% CI: 1.07–1.17) for 90-day mortality, and 1.13 (95% CI: 1.08–1.18) for 365-day mortality. The RCS analysis indicated a nonlinear relationship. Kaplan-Meier analysis demonstrated significantly higher mortality in the high-RDW group compared to the low-RDW group (p < 0.001). The area under the curve (AUC) for RDW was greater than that for BISAP and SIRS, but lower than the SOFA. Subgroup analyses showed no significant interactions between RDW and most subgroups. Conclusion Elevated RDW is independently associated with increased short- and long-term all-cause mortality in patients with AP and sepsis.https://doi.org/10.1186/s12876-025-04167-5Red blood cell distribution widthAcute pancreatitisSepsisAll-cause mortalityMIMIC-IV. |
| spellingShingle | Qingzhou Song Xuanlin Wu Firooz Ahmad Taheri Linghou Meng Wentao Wang Xianwei Mo Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis BMC Gastroenterology Red blood cell distribution width Acute pancreatitis Sepsis All-cause mortality MIMIC-IV. |
| title | Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis |
| title_full | Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis |
| title_fullStr | Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis |
| title_full_unstemmed | Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis |
| title_short | Association of red blood cell distribution width with short- and long-term all-cause mortality in patients with acute pancreatitis and sepsis |
| title_sort | association of red blood cell distribution width with short and long term all cause mortality in patients with acute pancreatitis and sepsis |
| topic | Red blood cell distribution width Acute pancreatitis Sepsis All-cause mortality MIMIC-IV. |
| url | https://doi.org/10.1186/s12876-025-04167-5 |
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