Recurrent Spontaneous Tumor Lysis Syndrome in Undiagnosed Follicular T-Cell Lymphoma
Introduction: Spontaneous tumor lysis syndrome (TLS) is a rare, life-threatening metabolic complication that typically occurs in malignancies with high tumor burden. Early recognition is critical, even in the absence of a known malignancy, to prevent severe outcomes. Case Presenta...
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| Format: | Article |
| Language: | English |
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Karger Publishers
2025-02-01
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| Series: | Case Reports in Oncology |
| Online Access: | https://karger.com/article/doi/10.1159/000544865 |
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| author | Feehaan H. Sultan Priya K. Jindal Zeeshaan H. Sultan Nahush R. Bansal Shuhao Qiu |
| author_facet | Feehaan H. Sultan Priya K. Jindal Zeeshaan H. Sultan Nahush R. Bansal Shuhao Qiu |
| author_sort | Feehaan H. Sultan |
| collection | DOAJ |
| description |
Introduction:
Spontaneous tumor lysis syndrome (TLS) is a rare, life-threatening metabolic complication that typically occurs in malignancies with high tumor burden. Early recognition is critical, even in the absence of a known malignancy, to prevent severe outcomes.
Case Presentation:
We report the case of an 89-year-old male with a history of chronic kidney disease, hyperparathyroidism, and myasthenia gravis, who experienced three episodes of TLS within 1 month. Initially, his metabolic disturbances were misattributed to dehydration. During his second admission, imaging revealed extensive lymphadenopathy, and a lymph node biopsy confirmed follicular helper T-cell lymphoma before his third hospitalization. Despite aggressive treatment, he developed metabolic encephalopathy and lost his decision-making capacity, while his family declined palliative care discussions.
Conclusion:
This case highlights the importance of considering TLS in patients with unexplained hyperkalemia, hyperuricemia, and hyperphosphatemia, even in the absence of a malignancy diagnosis. Early diagnosis and multidisciplinary care are essential to improve outcomes.
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| format | Article |
| id | doaj-art-e7def169f7ce4a81ab300ec37b12b07e |
| institution | OA Journals |
| issn | 1662-6575 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj-art-e7def169f7ce4a81ab300ec37b12b07e2025-08-20T01:51:04ZengKarger PublishersCase Reports in Oncology1662-65752025-02-0118141341910.1159/000544865Recurrent Spontaneous Tumor Lysis Syndrome in Undiagnosed Follicular T-Cell LymphomaFeehaan H. SultanPriya K. JindalZeeshaan H. SultanNahush R. BansalShuhao Qiu Introduction: Spontaneous tumor lysis syndrome (TLS) is a rare, life-threatening metabolic complication that typically occurs in malignancies with high tumor burden. Early recognition is critical, even in the absence of a known malignancy, to prevent severe outcomes. Case Presentation: We report the case of an 89-year-old male with a history of chronic kidney disease, hyperparathyroidism, and myasthenia gravis, who experienced three episodes of TLS within 1 month. Initially, his metabolic disturbances were misattributed to dehydration. During his second admission, imaging revealed extensive lymphadenopathy, and a lymph node biopsy confirmed follicular helper T-cell lymphoma before his third hospitalization. Despite aggressive treatment, he developed metabolic encephalopathy and lost his decision-making capacity, while his family declined palliative care discussions. Conclusion: This case highlights the importance of considering TLS in patients with unexplained hyperkalemia, hyperuricemia, and hyperphosphatemia, even in the absence of a malignancy diagnosis. Early diagnosis and multidisciplinary care are essential to improve outcomes. https://karger.com/article/doi/10.1159/000544865 |
| spellingShingle | Feehaan H. Sultan Priya K. Jindal Zeeshaan H. Sultan Nahush R. Bansal Shuhao Qiu Recurrent Spontaneous Tumor Lysis Syndrome in Undiagnosed Follicular T-Cell Lymphoma Case Reports in Oncology |
| title | Recurrent Spontaneous Tumor Lysis Syndrome in Undiagnosed Follicular T-Cell Lymphoma |
| title_full | Recurrent Spontaneous Tumor Lysis Syndrome in Undiagnosed Follicular T-Cell Lymphoma |
| title_fullStr | Recurrent Spontaneous Tumor Lysis Syndrome in Undiagnosed Follicular T-Cell Lymphoma |
| title_full_unstemmed | Recurrent Spontaneous Tumor Lysis Syndrome in Undiagnosed Follicular T-Cell Lymphoma |
| title_short | Recurrent Spontaneous Tumor Lysis Syndrome in Undiagnosed Follicular T-Cell Lymphoma |
| title_sort | recurrent spontaneous tumor lysis syndrome in undiagnosed follicular t cell lymphoma |
| url | https://karger.com/article/doi/10.1159/000544865 |
| work_keys_str_mv | AT feehaanhsultan recurrentspontaneoustumorlysissyndromeinundiagnosedfolliculartcelllymphoma AT priyakjindal recurrentspontaneoustumorlysissyndromeinundiagnosedfolliculartcelllymphoma AT zeeshaanhsultan recurrentspontaneoustumorlysissyndromeinundiagnosedfolliculartcelllymphoma AT nahushrbansal recurrentspontaneoustumorlysissyndromeinundiagnosedfolliculartcelllymphoma AT shuhaoqiu recurrentspontaneoustumorlysissyndromeinundiagnosedfolliculartcelllymphoma |