Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directions
The pathogenesis of inflammatory bowel disease (IBD) is complex and multifactorial. Undertreated disease has substantial individual and societal consequences. Current patient classification and subsequent positioning of IBD therapy are based on crude, readily accessible clinical data. These broad pa...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-02-01
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| Series: | eGastroenterology |
| Online Access: | https://egastroenterology.bmj.com/content/2/1/e100006.full |
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| author | Peter R Gibson Miles P Sparrow Fan Zhang Georgina L Hold Alex Boussioutas Susan J Connor Robert D Little Thisun Jayawardana Sabrina Koentgen Mark G Ward |
| author_facet | Peter R Gibson Miles P Sparrow Fan Zhang Georgina L Hold Alex Boussioutas Susan J Connor Robert D Little Thisun Jayawardana Sabrina Koentgen Mark G Ward |
| author_sort | Peter R Gibson |
| collection | DOAJ |
| description | The pathogenesis of inflammatory bowel disease (IBD) is complex and multifactorial. Undertreated disease has substantial individual and societal consequences. Current patient classification and subsequent positioning of IBD therapy are based on crude, readily accessible clinical data. These broad parameters are unlikely to reflect underlying molecular profiles and may account for the observed heterogeneity in treatment response. Precision medicine offers identification and integration of molecular profiles into clinical decision-making. Despite several promising scientific and technological advances, the pathogenesis and targetable molecular drivers of IBD remain incompletely understood. Precision medicine therefore remains aspirational. This comprehensive narrative review describes our current understanding of IBD pathophysiology, highlights preliminary genetic, immunological and microbial predictors of treatment response and outlines the role of ‘big data’ and machine learning in the path towards precision medicine. |
| format | Article |
| id | doaj-art-e7dbfb915d5640beb659756b18fe8572 |
| institution | DOAJ |
| issn | 2766-0125 2976-7296 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | eGastroenterology |
| spelling | doaj-art-e7dbfb915d5640beb659756b18fe85722025-08-20T02:39:25ZengBMJ Publishing GroupeGastroenterology2766-01252976-72962024-02-012110.1136/egastro-2023-100006Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directionsPeter R Gibson0Miles P Sparrow1Fan Zhang2Georgina L Hold3Alex Boussioutas4Susan J Connor5Robert D Little6Thisun Jayawardana7Sabrina Koentgen8Mark G Ward92 Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, AustraliaDepartment of Gastroenterology, Alfred Hospital, Melbourne, Victoria, AustraliaDepartment of Pathophysiology, Guizhou Medical University, Guiyang, China3 Microbiome Research Centre, University of New South Wales, Sydney, New South Wales, Australia2 Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, AustraliaDepartment of Gastroenterology, Liverpool Hospital, Sydney, New South Wales, Australia2 Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Victoria, Australia3 Microbiome Research Centre, University of New South Wales, Sydney, New South Wales, Australia3 Microbiome Research Centre, University of New South Wales, Sydney, New South Wales, AustraliaDepartment of Gastroenterology, Alfred Hospital, Melbourne, Victoria, AustraliaThe pathogenesis of inflammatory bowel disease (IBD) is complex and multifactorial. Undertreated disease has substantial individual and societal consequences. Current patient classification and subsequent positioning of IBD therapy are based on crude, readily accessible clinical data. These broad parameters are unlikely to reflect underlying molecular profiles and may account for the observed heterogeneity in treatment response. Precision medicine offers identification and integration of molecular profiles into clinical decision-making. Despite several promising scientific and technological advances, the pathogenesis and targetable molecular drivers of IBD remain incompletely understood. Precision medicine therefore remains aspirational. This comprehensive narrative review describes our current understanding of IBD pathophysiology, highlights preliminary genetic, immunological and microbial predictors of treatment response and outlines the role of ‘big data’ and machine learning in the path towards precision medicine.https://egastroenterology.bmj.com/content/2/1/e100006.full |
| spellingShingle | Peter R Gibson Miles P Sparrow Fan Zhang Georgina L Hold Alex Boussioutas Susan J Connor Robert D Little Thisun Jayawardana Sabrina Koentgen Mark G Ward Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directions eGastroenterology |
| title | Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directions |
| title_full | Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directions |
| title_fullStr | Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directions |
| title_full_unstemmed | Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directions |
| title_short | Pathogenesis and precision medicine for predicting response in inflammatory bowel disease: advances and future directions |
| title_sort | pathogenesis and precision medicine for predicting response in inflammatory bowel disease advances and future directions |
| url | https://egastroenterology.bmj.com/content/2/1/e100006.full |
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