ADRENO- AND CHOLINOREACTIVITY OF ERYTHROCYTES AND ESTIMATION OF THEIR CONJUGATION WITH PARAMETERS OF FREE RADICAL BALANCE OF BLOOD IN NON-LINEAR RATS
The values of the β-adrenoreactivity of erythrocytes (β-ARE, 40.6 ± 2.3 rel. units) and the M-cholinoreactivity of erythrocytes (M-ChRE, 7.9 ± 0.3 rel. units), concentration of hemoglobin, the parameters of free radical balance: the level of TBA-reactive products (TBA-RP) and catalase activity in er...
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Russian Academy of Sciences, Siberian Branch Publishing House
2019-09-01
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| Series: | Сибирский научный медицинский журнал |
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| Online Access: | https://sibmed.elpub.ru/jour/article/view/206 |
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| author | E. V. Kuryanova A. V. Tryasuchev D. L. Teply |
| author_facet | E. V. Kuryanova A. V. Tryasuchev D. L. Teply |
| author_sort | E. V. Kuryanova |
| collection | DOAJ |
| description | The values of the β-adrenoreactivity of erythrocytes (β-ARE, 40.6 ± 2.3 rel. units) and the M-cholinoreactivity of erythrocytes (M-ChRE, 7.9 ± 0.3 rel. units), concentration of hemoglobin, the parameters of free radical balance: the level of TBA-reactive products (TBA-RP) and catalase activity in erythrocytes and plasma were determined in male non-linear rats. Sample grouping by clustering largest β-ARE showed that rats with a high β-ARE (>50 rel. units) have a greater concentration of hemoglobin, TBA-RP and CAT in erythrocytes, than rats with an average (30 to 50 rel. units) and low (<30 rel. units) β-ARE. According to the results of the correlation and factor analysis, M-ChRE is predominantly conjugated with erythrocyte (Factor 1), and β-ARE – with plasma characteristics of free radical balance in blood (Factor 3). The introduction of β-adrenergic blocker anapriline (2 mg/kg bw) decreases β-ARE and potentiates the accumulation of TBA-RP in the erythrocytes and plasma, the administration of the blocker of M-cholinergic receptors atropine (1 mg/kg bw) reduces not only M-ChRE, but also β-ARE and promotes the growth of erythrocyte catalase activity. Thus, in the intact state, under the conditions of blockade of adrenergic receptor and cholinergic receptors, dependences have been revealed that make it possible to treat β-ARE and M-ChRE as a link between regulatory influences on erythrocytes and biochemical, including free radical processes in the «erythrocyte – blood plasma». |
| format | Article |
| id | doaj-art-e7d9d54bbb6b402680fa051ad35c2433 |
| institution | Kabale University |
| issn | 2410-2512 2410-2520 |
| language | Russian |
| publishDate | 2019-09-01 |
| publisher | Russian Academy of Sciences, Siberian Branch Publishing House |
| record_format | Article |
| series | Сибирский научный медицинский журнал |
| spelling | doaj-art-e7d9d54bbb6b402680fa051ad35c24332025-08-20T03:50:44ZrusRussian Academy of Sciences, Siberian Branch Publishing HouseСибирский научный медицинский журнал2410-25122410-25202019-09-01394374510.15372/SSMJ20190405164ADRENO- AND CHOLINOREACTIVITY OF ERYTHROCYTES AND ESTIMATION OF THEIR CONJUGATION WITH PARAMETERS OF FREE RADICAL BALANCE OF BLOOD IN NON-LINEAR RATSE. V. Kuryanova0A. V. Tryasuchev1D. L. Teply2The Astrakhan State UniversityThe Astrakhan State UniversityThe Astrakhan State UniversityThe values of the β-adrenoreactivity of erythrocytes (β-ARE, 40.6 ± 2.3 rel. units) and the M-cholinoreactivity of erythrocytes (M-ChRE, 7.9 ± 0.3 rel. units), concentration of hemoglobin, the parameters of free radical balance: the level of TBA-reactive products (TBA-RP) and catalase activity in erythrocytes and plasma were determined in male non-linear rats. Sample grouping by clustering largest β-ARE showed that rats with a high β-ARE (>50 rel. units) have a greater concentration of hemoglobin, TBA-RP and CAT in erythrocytes, than rats with an average (30 to 50 rel. units) and low (<30 rel. units) β-ARE. According to the results of the correlation and factor analysis, M-ChRE is predominantly conjugated with erythrocyte (Factor 1), and β-ARE – with plasma characteristics of free radical balance in blood (Factor 3). The introduction of β-adrenergic blocker anapriline (2 mg/kg bw) decreases β-ARE and potentiates the accumulation of TBA-RP in the erythrocytes and plasma, the administration of the blocker of M-cholinergic receptors atropine (1 mg/kg bw) reduces not only M-ChRE, but also β-ARE and promotes the growth of erythrocyte catalase activity. Thus, in the intact state, under the conditions of blockade of adrenergic receptor and cholinergic receptors, dependences have been revealed that make it possible to treat β-ARE and M-ChRE as a link between regulatory influences on erythrocytes and biochemical, including free radical processes in the «erythrocyte – blood plasma».https://sibmed.elpub.ru/jour/article/view/206adreno- and cholinoreactivity of erythrocytesfree radical balance of bloodanaprilineatropinenonlinear rats |
| spellingShingle | E. V. Kuryanova A. V. Tryasuchev D. L. Teply ADRENO- AND CHOLINOREACTIVITY OF ERYTHROCYTES AND ESTIMATION OF THEIR CONJUGATION WITH PARAMETERS OF FREE RADICAL BALANCE OF BLOOD IN NON-LINEAR RATS Сибирский научный медицинский журнал adreno- and cholinoreactivity of erythrocytes free radical balance of blood anapriline atropine nonlinear rats |
| title | ADRENO- AND CHOLINOREACTIVITY OF ERYTHROCYTES AND ESTIMATION OF THEIR CONJUGATION WITH PARAMETERS OF FREE RADICAL BALANCE OF BLOOD IN NON-LINEAR RATS |
| title_full | ADRENO- AND CHOLINOREACTIVITY OF ERYTHROCYTES AND ESTIMATION OF THEIR CONJUGATION WITH PARAMETERS OF FREE RADICAL BALANCE OF BLOOD IN NON-LINEAR RATS |
| title_fullStr | ADRENO- AND CHOLINOREACTIVITY OF ERYTHROCYTES AND ESTIMATION OF THEIR CONJUGATION WITH PARAMETERS OF FREE RADICAL BALANCE OF BLOOD IN NON-LINEAR RATS |
| title_full_unstemmed | ADRENO- AND CHOLINOREACTIVITY OF ERYTHROCYTES AND ESTIMATION OF THEIR CONJUGATION WITH PARAMETERS OF FREE RADICAL BALANCE OF BLOOD IN NON-LINEAR RATS |
| title_short | ADRENO- AND CHOLINOREACTIVITY OF ERYTHROCYTES AND ESTIMATION OF THEIR CONJUGATION WITH PARAMETERS OF FREE RADICAL BALANCE OF BLOOD IN NON-LINEAR RATS |
| title_sort | adreno and cholinoreactivity of erythrocytes and estimation of their conjugation with parameters of free radical balance of blood in non linear rats |
| topic | adreno- and cholinoreactivity of erythrocytes free radical balance of blood anapriline atropine nonlinear rats |
| url | https://sibmed.elpub.ru/jour/article/view/206 |
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