Efficacy and safety of Dengzhan Shengmai capsule in the treatment of chronic heart failure: a systematic review and meta-analysis
BackgroundDengzhan Shengmai Capsule (DZSMC) is a potential treatment for chronic heart failure (CHF). However, its specific benefits in the treatment of CHF remain unclear.MethodsRelated randomized controlled trials were searched in eight databases up to January 28, 2025, and included studies were d...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1385061/full |
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| author | Shenghua Lu Shenghua Lu Yunfeng Yu Sisi Dai Yaqi Hu Qin He Rongzhen Liu Jianhe Liu Jianhe Liu |
| author_facet | Shenghua Lu Shenghua Lu Yunfeng Yu Sisi Dai Yaqi Hu Qin He Rongzhen Liu Jianhe Liu Jianhe Liu |
| author_sort | Shenghua Lu |
| collection | DOAJ |
| description | BackgroundDengzhan Shengmai Capsule (DZSMC) is a potential treatment for chronic heart failure (CHF). However, its specific benefits in the treatment of CHF remain unclear.MethodsRelated randomized controlled trials were searched in eight databases up to January 28, 2025, and included studies were determined according to the inclusion criteria. Subsequently, the basic characteristics and data from these studies were recorded using Excel 2010. Outcome-related data were subsequently imported into Revman 5.3 for meta-analysis.ResultsFifteen randomized controlled trials with 1606 patients were included in this meta-analysis. The results showed that compared to conventional treatment group, DZSMC combination group significantly improved the clinical effective rate [RR = 1.21, 95% CI (1.16,1.26), P < 0.00001], brain natriuretic peptide (BNP) [MD = −112.60, 95%CI (−212.23, −12.96), P = 0.03], N-terminal pro-B-type natriuretic peptide (NT-proBNP) [MD = −88.27, 95%CI (−108.11, −68.42), P < 0.00001], left ventricular ejection fraction (LVEF) [MD = 6.42, 95% CI (5.57, 7.27), P < 0.00001], left ventricular end-diastolic diameter (LVEDD) [MD = −5.72, 95% CI (−7.56, −3.87), P < 0.00001], left ventricular end-systolic diameter (LVESD) [MD = −5.33, 95% CI (−7.41, −3.26), P < 0.00001], left ventricular end-systolic volume (LVESV) [MD = −20.71, 95% CI (−34.59, −6.82), P = 0.003], and 6 min walk test [MD = 51.90, 95%CI (19.08, 84.72), P = 0.002], while adverse events had no significant difference [RR = 0.70, 95%CI (0.42, 1.17), P = 0.17]. Funnel plots indicated no publication bias for BNP, NT-proBNP, LVEF, and LVESD, while potential bias was observed for other outcomes.ConclusionDZSMC effectively improves clinical symptoms, cardiac function, and ventricular remodeling in CHF patients, with good safety, making it a potential adjuvant therapy for CHF. However, further research is needed to explore the long-term safety of DZSMC in order to enrich clinical evidence.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024507368, PROSPERO [CRD42024507368]. |
| format | Article |
| id | doaj-art-e7d6654a050e4bc9877f6dac19ee8e92 |
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| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-e7d6654a050e4bc9877f6dac19ee8e922025-08-20T03:01:14ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-02-011210.3389/fcvm.2025.13850611385061Efficacy and safety of Dengzhan Shengmai capsule in the treatment of chronic heart failure: a systematic review and meta-analysisShenghua Lu0Shenghua Lu1Yunfeng Yu2Sisi Dai3Yaqi Hu4Qin He5Rongzhen Liu6Jianhe Liu7Jianhe Liu8Department of Cardiovascular Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaBranch of National Clinical Research Center for Chinese Medicine Cardiology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaDepartment of Cardiovascular Medicine, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaBranch of National Clinical Research Center for Chinese Medicine Cardiology, The First Hospital of Hunan University of Chinese Medicine, Changsha, Hunan, ChinaBackgroundDengzhan Shengmai Capsule (DZSMC) is a potential treatment for chronic heart failure (CHF). However, its specific benefits in the treatment of CHF remain unclear.MethodsRelated randomized controlled trials were searched in eight databases up to January 28, 2025, and included studies were determined according to the inclusion criteria. Subsequently, the basic characteristics and data from these studies were recorded using Excel 2010. Outcome-related data were subsequently imported into Revman 5.3 for meta-analysis.ResultsFifteen randomized controlled trials with 1606 patients were included in this meta-analysis. The results showed that compared to conventional treatment group, DZSMC combination group significantly improved the clinical effective rate [RR = 1.21, 95% CI (1.16,1.26), P < 0.00001], brain natriuretic peptide (BNP) [MD = −112.60, 95%CI (−212.23, −12.96), P = 0.03], N-terminal pro-B-type natriuretic peptide (NT-proBNP) [MD = −88.27, 95%CI (−108.11, −68.42), P < 0.00001], left ventricular ejection fraction (LVEF) [MD = 6.42, 95% CI (5.57, 7.27), P < 0.00001], left ventricular end-diastolic diameter (LVEDD) [MD = −5.72, 95% CI (−7.56, −3.87), P < 0.00001], left ventricular end-systolic diameter (LVESD) [MD = −5.33, 95% CI (−7.41, −3.26), P < 0.00001], left ventricular end-systolic volume (LVESV) [MD = −20.71, 95% CI (−34.59, −6.82), P = 0.003], and 6 min walk test [MD = 51.90, 95%CI (19.08, 84.72), P = 0.002], while adverse events had no significant difference [RR = 0.70, 95%CI (0.42, 1.17), P = 0.17]. Funnel plots indicated no publication bias for BNP, NT-proBNP, LVEF, and LVESD, while potential bias was observed for other outcomes.ConclusionDZSMC effectively improves clinical symptoms, cardiac function, and ventricular remodeling in CHF patients, with good safety, making it a potential adjuvant therapy for CHF. However, further research is needed to explore the long-term safety of DZSMC in order to enrich clinical evidence.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024507368, PROSPERO [CRD42024507368].https://www.frontiersin.org/articles/10.3389/fcvm.2025.1385061/fullDengzhan Shengmai capsulechronic heart failurecardiac functionsystematic reviewmeta-analysis |
| spellingShingle | Shenghua Lu Shenghua Lu Yunfeng Yu Sisi Dai Yaqi Hu Qin He Rongzhen Liu Jianhe Liu Jianhe Liu Efficacy and safety of Dengzhan Shengmai capsule in the treatment of chronic heart failure: a systematic review and meta-analysis Frontiers in Cardiovascular Medicine Dengzhan Shengmai capsule chronic heart failure cardiac function systematic review meta-analysis |
| title | Efficacy and safety of Dengzhan Shengmai capsule in the treatment of chronic heart failure: a systematic review and meta-analysis |
| title_full | Efficacy and safety of Dengzhan Shengmai capsule in the treatment of chronic heart failure: a systematic review and meta-analysis |
| title_fullStr | Efficacy and safety of Dengzhan Shengmai capsule in the treatment of chronic heart failure: a systematic review and meta-analysis |
| title_full_unstemmed | Efficacy and safety of Dengzhan Shengmai capsule in the treatment of chronic heart failure: a systematic review and meta-analysis |
| title_short | Efficacy and safety of Dengzhan Shengmai capsule in the treatment of chronic heart failure: a systematic review and meta-analysis |
| title_sort | efficacy and safety of dengzhan shengmai capsule in the treatment of chronic heart failure a systematic review and meta analysis |
| topic | Dengzhan Shengmai capsule chronic heart failure cardiac function systematic review meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1385061/full |
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