Regulation of pyroptosis by NF-κB signaling
Pyroptosis is a form of proinflammatory cell death characterized by inflammasome activation, pore formation, and the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 upon cell rupture. Nuclear factor-κB (NF-κB), a prototypical pro-inflammatory transcription factor, play...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Cell Death |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fceld.2024.1503799/full |
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| author | Ling Yang Yan Zhang Zhuodong Chai Yuqi Zhou Zhenyu Li Yinan Wei |
| author_facet | Ling Yang Yan Zhang Zhuodong Chai Yuqi Zhou Zhenyu Li Yinan Wei |
| author_sort | Ling Yang |
| collection | DOAJ |
| description | Pyroptosis is a form of proinflammatory cell death characterized by inflammasome activation, pore formation, and the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 upon cell rupture. Nuclear factor-κB (NF-κB), a prototypical pro-inflammatory transcription factor, plays a critical role in immune system regulation. Recent research highlights the multifaceted roles of NF-κB signaling in pyroptosis. Various immunologically relevant ligands and their receptors can activate the NF-κB pathway to promote pyroptosis, with Toll-like receptors (TLRs), IL-1 receptors (IL-1Rs), and TNF receptors (TNFRs) being the most prominent. NF-κB regulates the transcription of key components of inflammasomes involved in pyroptosis, particularly the NLRP3 inflammasome. Recent studies also indicate that NF-κB modulates the activation of NLRC4 and AIM2 inflammasomes through distinct pathways in diverse inflammatory conditions, such as acute lung injury and neuroinflammation. Additionally, the NF-κB pathway mediates the production of inflammatory cytokines, including IL-1β, IL-33, and TNF-α, which further regulate pyroptosis. This review examines recent advances in understanding the role of the NF-κB signaling pathway in regulating pyroptosis during infection and inflammation. |
| format | Article |
| id | doaj-art-e7d5becb4d0c4939a05235a5071ee01a |
| institution | DOAJ |
| issn | 2813-5563 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell Death |
| spelling | doaj-art-e7d5becb4d0c4939a05235a5071ee01a2025-08-20T02:45:30ZengFrontiers Media S.A.Frontiers in Cell Death2813-55632025-01-01310.3389/fceld.2024.15037991503799Regulation of pyroptosis by NF-κB signalingLing YangYan ZhangZhuodong ChaiYuqi ZhouZhenyu LiYinan WeiPyroptosis is a form of proinflammatory cell death characterized by inflammasome activation, pore formation, and the release of pro-inflammatory cytokines such as interleukin-1β (IL-1β) and IL-18 upon cell rupture. Nuclear factor-κB (NF-κB), a prototypical pro-inflammatory transcription factor, plays a critical role in immune system regulation. Recent research highlights the multifaceted roles of NF-κB signaling in pyroptosis. Various immunologically relevant ligands and their receptors can activate the NF-κB pathway to promote pyroptosis, with Toll-like receptors (TLRs), IL-1 receptors (IL-1Rs), and TNF receptors (TNFRs) being the most prominent. NF-κB regulates the transcription of key components of inflammasomes involved in pyroptosis, particularly the NLRP3 inflammasome. Recent studies also indicate that NF-κB modulates the activation of NLRC4 and AIM2 inflammasomes through distinct pathways in diverse inflammatory conditions, such as acute lung injury and neuroinflammation. Additionally, the NF-κB pathway mediates the production of inflammatory cytokines, including IL-1β, IL-33, and TNF-α, which further regulate pyroptosis. This review examines recent advances in understanding the role of the NF-κB signaling pathway in regulating pyroptosis during infection and inflammation.https://www.frontiersin.org/articles/10.3389/fceld.2024.1503799/fullpyroptosisNF-κBinflammasomeinfectioninflammation |
| spellingShingle | Ling Yang Yan Zhang Zhuodong Chai Yuqi Zhou Zhenyu Li Yinan Wei Regulation of pyroptosis by NF-κB signaling Frontiers in Cell Death pyroptosis NF-κB inflammasome infection inflammation |
| title | Regulation of pyroptosis by NF-κB signaling |
| title_full | Regulation of pyroptosis by NF-κB signaling |
| title_fullStr | Regulation of pyroptosis by NF-κB signaling |
| title_full_unstemmed | Regulation of pyroptosis by NF-κB signaling |
| title_short | Regulation of pyroptosis by NF-κB signaling |
| title_sort | regulation of pyroptosis by nf κb signaling |
| topic | pyroptosis NF-κB inflammasome infection inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fceld.2024.1503799/full |
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