POLYMORPHISMS OF MATRIX METALLOPROTEASES 2 AND 9 GENES IN ASCENDING AORTA ANEURISM PATIENTS
Aim. To study the role of mononucleotide polymorphisms of the matrix metalloproteases genes MMP2 and MMP9 in the development of ascending aorta aneurism (AOA).Material and methods. Totally 287 patients included with AOA and 227 persons of control group. All patients underwent echocardiography and as...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
«FIRMA «SILICEA» LLC
2015-10-01
|
| Series: | Российский кардиологический журнал |
| Subjects: | |
| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/312 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850029115811299328 |
|---|---|
| author | N. D. Gavrilyuk O. B. Irtyuga T. A. Druzhkova V. E. Uspensky A. B. Malashicheva A. A. Kostareva O. M. Moiseeva |
| author_facet | N. D. Gavrilyuk O. B. Irtyuga T. A. Druzhkova V. E. Uspensky A. B. Malashicheva A. A. Kostareva O. M. Moiseeva |
| author_sort | N. D. Gavrilyuk |
| collection | DOAJ |
| description | Aim. To study the role of mononucleotide polymorphisms of the matrix metalloproteases genes MMP2 and MMP9 in the development of ascending aorta aneurism (AOA).Material and methods. Totally 287 patients included with AOA and 227 persons of control group. All patients underwent echocardiography and assessment of mononucleotide gene polymorphisms of MMP2 (rs2285053) and MMP9 (rs11697325, rs2274755, rs17577) real-time, by PCR.Results. The association of MMP9 (rs11697325) is confirmed for the formation of AOA. AA genotype was significantly more prevalent among AOA patients (c2 =7,2; p=0,01). AA genotype carriers had higher ascending aorta diameter comparing to other persons with different variants (p=0,02). The relation is shown of the polymorphism ММР2 (rs2285053) and AOA development. Persons with CC genotype were more prevalent in the group of the aorta pathology patients (c2 =7,0; р=0,03).Conclusion. Genetic variants ММР9 and ММР2 can be additional risk factors of ascending aorta aneurism development. Therefore the assessment of different polymorphisms of matrix metalloproteases genes is useful for the risk stratification of the patients with ascending aorta dilation. |
| format | Article |
| id | doaj-art-e7d290737a9042f9811d297d72c9b95a |
| institution | DOAJ |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2015-10-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-e7d290737a9042f9811d297d72c9b95a2025-08-20T02:59:37Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202015-10-01010656910.15829/1560-4071-2015-10-65-69312POLYMORPHISMS OF MATRIX METALLOPROTEASES 2 AND 9 GENES IN ASCENDING AORTA ANEURISM PATIENTSN. D. Gavrilyuk0O. B. Irtyuga1T. A. Druzhkova2V. E. Uspensky3A. B. Malashicheva4A. A. Kostareva5O. M. Moiseeva6North-Western Federal Medical Investigation Center, Saint-PetersburgNorth-Western Federal Medical Investigation Center, Saint-PetersburgNorth-Western Federal Medical Investigation Center, Saint-PetersburgNorth-Western Federal Medical Investigation Center, Saint-PetersburgNorth-Western Federal Medical Investigation Center, Saint-Petersburg; Saint-Petersburg State UniversityNorth-Western Federal Medical Investigation Center, Saint-PetersburgNorth-Western Federal Medical Investigation Center, Saint-PetersburgAim. To study the role of mononucleotide polymorphisms of the matrix metalloproteases genes MMP2 and MMP9 in the development of ascending aorta aneurism (AOA).Material and methods. Totally 287 patients included with AOA and 227 persons of control group. All patients underwent echocardiography and assessment of mononucleotide gene polymorphisms of MMP2 (rs2285053) and MMP9 (rs11697325, rs2274755, rs17577) real-time, by PCR.Results. The association of MMP9 (rs11697325) is confirmed for the formation of AOA. AA genotype was significantly more prevalent among AOA patients (c2 =7,2; p=0,01). AA genotype carriers had higher ascending aorta diameter comparing to other persons with different variants (p=0,02). The relation is shown of the polymorphism ММР2 (rs2285053) and AOA development. Persons with CC genotype were more prevalent in the group of the aorta pathology patients (c2 =7,0; р=0,03).Conclusion. Genetic variants ММР9 and ММР2 can be additional risk factors of ascending aorta aneurism development. Therefore the assessment of different polymorphisms of matrix metalloproteases genes is useful for the risk stratification of the patients with ascending aorta dilation.https://russjcardiol.elpub.ru/jour/article/view/312ascending aorta aneurismhereditymatrix metalloproteasesmononucleotide polymorphism |
| spellingShingle | N. D. Gavrilyuk O. B. Irtyuga T. A. Druzhkova V. E. Uspensky A. B. Malashicheva A. A. Kostareva O. M. Moiseeva POLYMORPHISMS OF MATRIX METALLOPROTEASES 2 AND 9 GENES IN ASCENDING AORTA ANEURISM PATIENTS Российский кардиологический журнал ascending aorta aneurism heredity matrix metalloproteases mononucleotide polymorphism |
| title | POLYMORPHISMS OF MATRIX METALLOPROTEASES 2 AND 9 GENES IN ASCENDING AORTA ANEURISM PATIENTS |
| title_full | POLYMORPHISMS OF MATRIX METALLOPROTEASES 2 AND 9 GENES IN ASCENDING AORTA ANEURISM PATIENTS |
| title_fullStr | POLYMORPHISMS OF MATRIX METALLOPROTEASES 2 AND 9 GENES IN ASCENDING AORTA ANEURISM PATIENTS |
| title_full_unstemmed | POLYMORPHISMS OF MATRIX METALLOPROTEASES 2 AND 9 GENES IN ASCENDING AORTA ANEURISM PATIENTS |
| title_short | POLYMORPHISMS OF MATRIX METALLOPROTEASES 2 AND 9 GENES IN ASCENDING AORTA ANEURISM PATIENTS |
| title_sort | polymorphisms of matrix metalloproteases 2 and 9 genes in ascending aorta aneurism patients |
| topic | ascending aorta aneurism heredity matrix metalloproteases mononucleotide polymorphism |
| url | https://russjcardiol.elpub.ru/jour/article/view/312 |
| work_keys_str_mv | AT ndgavrilyuk polymorphismsofmatrixmetalloproteases2and9genesinascendingaortaaneurismpatients AT obirtyuga polymorphismsofmatrixmetalloproteases2and9genesinascendingaortaaneurismpatients AT tadruzhkova polymorphismsofmatrixmetalloproteases2and9genesinascendingaortaaneurismpatients AT veuspensky polymorphismsofmatrixmetalloproteases2and9genesinascendingaortaaneurismpatients AT abmalashicheva polymorphismsofmatrixmetalloproteases2and9genesinascendingaortaaneurismpatients AT aakostareva polymorphismsofmatrixmetalloproteases2and9genesinascendingaortaaneurismpatients AT ommoiseeva polymorphismsofmatrixmetalloproteases2and9genesinascendingaortaaneurismpatients |