Dengue Fever: Causes, Complications, and Vaccine Strategies
Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes. Dengue disease varies from mild fever to severe conditions of deng...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2016/6803098 |
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| author | Niyati Khetarpal Ira Khanna |
| author_facet | Niyati Khetarpal Ira Khanna |
| author_sort | Niyati Khetarpal |
| collection | DOAJ |
| description | Dengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. Globalization, increased air travel, and unplanned urbanization have led to increase in the rate of infection and helped dengue to expand its geographic and demographic distribution. Dengue vaccine development has been a challenging task due to the existence of four antigenically distinct dengue virus serotypes, each capable of eliciting cross-reactive and disease-enhancing antibody response against the remaining three serotypes. Recently, Sanofi Pasteur’s chimeric live-attenuated dengue vaccine candidate has been approved in Mexico, Brazil, and Philippines for usage in adults between 9 and 45 years of age. The impact of its limited application to the public health system needs to be evaluated. Simultaneously, the restricted application of this vaccine candidate warrants continued efforts in developing a dengue vaccine candidate which is additionally efficacious for infants and naïve individuals. In this context, alternative strategies of developing a designed vaccine candidate which does not allow production of enhancing antibodies should be explored, as it may expand the umbrella of efficacy to include infants and naïve individuals. |
| format | Article |
| id | doaj-art-e7cfd62846344d3387f657d639a85acb |
| institution | OA Journals |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
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| series | Journal of Immunology Research |
| spelling | doaj-art-e7cfd62846344d3387f657d639a85acb2025-08-20T02:22:15ZengWileyJournal of Immunology Research2314-88612314-71562016-01-01201610.1155/2016/68030986803098Dengue Fever: Causes, Complications, and Vaccine StrategiesNiyati Khetarpal0Ira Khanna1International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, IndiaInternational Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, IndiaDengue is a highly endemic infectious disease of the tropical countries and is rapidly becoming a global burden. It is caused by any of the 4 serotypes of dengue virus and is transmitted within humans through female Aedes mosquitoes. Dengue disease varies from mild fever to severe conditions of dengue hemorrhagic fever and shock syndrome. Globalization, increased air travel, and unplanned urbanization have led to increase in the rate of infection and helped dengue to expand its geographic and demographic distribution. Dengue vaccine development has been a challenging task due to the existence of four antigenically distinct dengue virus serotypes, each capable of eliciting cross-reactive and disease-enhancing antibody response against the remaining three serotypes. Recently, Sanofi Pasteur’s chimeric live-attenuated dengue vaccine candidate has been approved in Mexico, Brazil, and Philippines for usage in adults between 9 and 45 years of age. The impact of its limited application to the public health system needs to be evaluated. Simultaneously, the restricted application of this vaccine candidate warrants continued efforts in developing a dengue vaccine candidate which is additionally efficacious for infants and naïve individuals. In this context, alternative strategies of developing a designed vaccine candidate which does not allow production of enhancing antibodies should be explored, as it may expand the umbrella of efficacy to include infants and naïve individuals.http://dx.doi.org/10.1155/2016/6803098 |
| spellingShingle | Niyati Khetarpal Ira Khanna Dengue Fever: Causes, Complications, and Vaccine Strategies Journal of Immunology Research |
| title | Dengue Fever: Causes, Complications, and Vaccine Strategies |
| title_full | Dengue Fever: Causes, Complications, and Vaccine Strategies |
| title_fullStr | Dengue Fever: Causes, Complications, and Vaccine Strategies |
| title_full_unstemmed | Dengue Fever: Causes, Complications, and Vaccine Strategies |
| title_short | Dengue Fever: Causes, Complications, and Vaccine Strategies |
| title_sort | dengue fever causes complications and vaccine strategies |
| url | http://dx.doi.org/10.1155/2016/6803098 |
| work_keys_str_mv | AT niyatikhetarpal denguefevercausescomplicationsandvaccinestrategies AT irakhanna denguefevercausescomplicationsandvaccinestrategies |