Sex-specific DNA methylation changes in placental thyroid hormone regulatory genes following prenatal exposure to flame retardants

Sex-specific DNA methylation changes in placental thyroid hormone regulatory genes following prenatal exposure to flame retardants

Prenatal exposure to organophosphate esters (OPEs) and polybrominated diphenyl ethers (PBDEs) has been linked to disrupted fetal thyroid hormone (TH), though the underlying mechanisms remain unclear. Based on the S-MBCS cohort, we analyzed OPE metabolite concentrations in maternal urine during early...

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Bibliographic Details
Main Authors: Min Luan, Haijun Zhu, Fen Yang, Hong Liang, Xiuxia Song, Longmei Jin, Honglei Ji, Wei Yuan, Qihan Wu, Xiujuan Su, Maohua Miao
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
Organophosphate esters
Polybrominated diphenyl ethers
Placenta
Thyroid hormone
DNA methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651325011856
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