Fecal shedding and transmission of vaccine–derived poliovirus: A systematic review and meta–analysis
Objective: This review aims to summarize the emergence and transmission of vaccine-derived poliovirus (VDPV) across various geographies, its impacts, and the developments of immunization techniques and vaccines. Methods: This systematic review and meta-analysis followed Prioritization of Reporting I...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2025-01-01
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| Series: | One Health Bulletin |
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| Online Access: | https://journals.lww.com/10.4103/ohbl.ohbl_29_24 |
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| _version_ | 1850154242193489920 |
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| author | Gangerdiwala Mariya Yunus Kanchwala Aliasgar Taher Khan Adnan Akram Dudhane Suraj Anil Haji Sana Anis Abusufiyan Shaikh |
| author_facet | Gangerdiwala Mariya Yunus Kanchwala Aliasgar Taher Khan Adnan Akram Dudhane Suraj Anil Haji Sana Anis Abusufiyan Shaikh |
| author_sort | Gangerdiwala Mariya Yunus |
| collection | DOAJ |
| description | Objective:
This review aims to summarize the emergence and transmission of vaccine-derived poliovirus (VDPV) across various geographies, its impacts, and the developments of immunization techniques and vaccines.
Methods:
This systematic review and meta-analysis followed Prioritization of Reporting Items for Systematic Reviews and MetaAnalyses (PRIMSA) criteria and was registered with Prospective Systematic Reviews (CRD42023389248). We included clinical studies such as randomized controlled trials, cohort studies, case reports and cross-sectional studies accessing the fecal excretion of VDPV. Five independent reviewers selected appropriate and relevant studies from PubMed, ScienceDirect and Google Scholar published before January 2023. Statistical analyses were performed using odds ratios (OR) with 95% confidence intervals (Cl) and a random effects model to address heterogeneity (I2), with publication bias evaluated via funnel plots and statistical tests.
Results:
Out of the 83 initially identified studies, 9 were included in meta-analysis. Participants who received the first dose of monovalent oral polio vaccine (mOPV) did not show statistically significant fecal shedding compared to those treated with the second dose (OR: 1.02, 95% CI: 0.51-2.03, P=0.47). Individuals who received the novel oral polio vaccine (nOPV) significantly reduce virus fecal shedding after the second dose compared to the first dose (OR: 2.95. 95% CI: 1.39-6.25, P=0.00). Sero-conversion rates do not differ significantly between two doses in participants received mOPV (OR:1.10, 95% CI: 0.60-2.01, P=0.35), meanwhile nOPV exhibit a higher seroconversion rate (OR: 0.07, 95% CI: 0.01-0.67, P=0.01).
Conclusions:
This study provides the evidence supporting the clinical efficacy and safety of nOPV compared to mOPV. |
| format | Article |
| id | doaj-art-e7ca9b36f5434e498f21d9bf1ff349af |
| institution | OA Journals |
| issn | 2773-0344 2773-0352 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | One Health Bulletin |
| spelling | doaj-art-e7ca9b36f5434e498f21d9bf1ff349af2025-08-20T02:25:25ZengWolters Kluwer Medknow PublicationsOne Health Bulletin2773-03442773-03522025-01-0151253210.4103/ohbl.ohbl_29_24Fecal shedding and transmission of vaccine–derived poliovirus: A systematic review and meta–analysisGangerdiwala Mariya YunusKanchwala Aliasgar TaherKhan Adnan AkramDudhane Suraj AnilHaji Sana AnisAbusufiyan ShaikhObjective: This review aims to summarize the emergence and transmission of vaccine-derived poliovirus (VDPV) across various geographies, its impacts, and the developments of immunization techniques and vaccines. Methods: This systematic review and meta-analysis followed Prioritization of Reporting Items for Systematic Reviews and MetaAnalyses (PRIMSA) criteria and was registered with Prospective Systematic Reviews (CRD42023389248). We included clinical studies such as randomized controlled trials, cohort studies, case reports and cross-sectional studies accessing the fecal excretion of VDPV. Five independent reviewers selected appropriate and relevant studies from PubMed, ScienceDirect and Google Scholar published before January 2023. Statistical analyses were performed using odds ratios (OR) with 95% confidence intervals (Cl) and a random effects model to address heterogeneity (I2), with publication bias evaluated via funnel plots and statistical tests. Results: Out of the 83 initially identified studies, 9 were included in meta-analysis. Participants who received the first dose of monovalent oral polio vaccine (mOPV) did not show statistically significant fecal shedding compared to those treated with the second dose (OR: 1.02, 95% CI: 0.51-2.03, P=0.47). Individuals who received the novel oral polio vaccine (nOPV) significantly reduce virus fecal shedding after the second dose compared to the first dose (OR: 2.95. 95% CI: 1.39-6.25, P=0.00). Sero-conversion rates do not differ significantly between two doses in participants received mOPV (OR:1.10, 95% CI: 0.60-2.01, P=0.35), meanwhile nOPV exhibit a higher seroconversion rate (OR: 0.07, 95% CI: 0.01-0.67, P=0.01). Conclusions: This study provides the evidence supporting the clinical efficacy and safety of nOPV compared to mOPV.https://journals.lww.com/10.4103/ohbl.ohbl_29_24oral polio vaccinefecal sheddingvaccine derived polio virusnovel oral polio vaccine (nopv)monovalent oral polio vaccine (mopv) |
| spellingShingle | Gangerdiwala Mariya Yunus Kanchwala Aliasgar Taher Khan Adnan Akram Dudhane Suraj Anil Haji Sana Anis Abusufiyan Shaikh Fecal shedding and transmission of vaccine–derived poliovirus: A systematic review and meta–analysis One Health Bulletin oral polio vaccine fecal shedding vaccine derived polio virus novel oral polio vaccine (nopv) monovalent oral polio vaccine (mopv) |
| title | Fecal shedding and transmission of vaccine–derived poliovirus: A systematic review and meta–analysis |
| title_full | Fecal shedding and transmission of vaccine–derived poliovirus: A systematic review and meta–analysis |
| title_fullStr | Fecal shedding and transmission of vaccine–derived poliovirus: A systematic review and meta–analysis |
| title_full_unstemmed | Fecal shedding and transmission of vaccine–derived poliovirus: A systematic review and meta–analysis |
| title_short | Fecal shedding and transmission of vaccine–derived poliovirus: A systematic review and meta–analysis |
| title_sort | fecal shedding and transmission of vaccine derived poliovirus a systematic review and meta analysis |
| topic | oral polio vaccine fecal shedding vaccine derived polio virus novel oral polio vaccine (nopv) monovalent oral polio vaccine (mopv) |
| url | https://journals.lww.com/10.4103/ohbl.ohbl_29_24 |
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