Transcriptomic, mutational and structural bioinformatics approaches to explore the therapeutic role of FAP in predominant cancer types

Transcriptomic, mutational and structural bioinformatics approaches to explore the therapeutic role of FAP in predominant cancer types

Abstract Fibroblast activating protein (FAP) is a cell surface marker of cancer-associated fibroblasts with a distinct pro-tumorigenic role. The present study analyzed the pan-cancer expression; and clinical and mutational profiles of the FAP coding gene. Molecular dynamics simulation (MDS) decipher...

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Bibliographic Details
Main Authors: Gayathri Ashok, Abdullah F. AlAsmari, Fawaz AlAsmari, Paul Livingstone, Anand Anbarasu, Sudha Ramaiah
Format: Article
Language:English
Published: Springer 2024-11-01
Series:Discover Oncology
Subjects:
Cancer-associated fibroblasts
Overall survival
Molecular docking
Molecular dynamics simulations
Mutations
Tumor microenvironment
Online Access:https://doi.org/10.1007/s12672-024-01531-x
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