Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer

Single-cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer

Abstract Background Cancer-associated fibroblasts (CAFs), known for facilitating the progression and metastasis of colorectal cancer (CRC), have become a promising therapeutic target. However, the significant heterogeneity of CAFs and their intricate crosstalk with tumor cells present substantial ch...

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Bibliographic Details
Main Authors: Yunfei Lu, Yang Chen, Zhenling Wang, Hengyang Shen, Lei Xu, Changzhi Huang, Ying Tong, Yu Shao, Hongqiang Zhang, Zan Fu
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Colorectal cancer
Single-cell RNA sequencing
Spatial transcriptomics
WNT5A
EMT
Online Access:https://doi.org/10.1186/s12967-025-06236-5
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