Acute and chronic effects of the short-chain chlorinated paraffins on the monogonont rotifer Brachionus manjavacas revealed by multi-biomarker determination
Short-chain chlorinated paraffins (SCCPs) are persistent organic pollutants of global concern. Despite their presence in low concentrations in aquatic environments, the detrimental effects of SCCPs on zooplankton remain limited. In this study, we evaluated the potential effects of acute and chronic...
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Elsevier
2025-04-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325004221 |
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| author | Jaehee Kim Seong Duk Do Jae-Sung Rhee |
| author_facet | Jaehee Kim Seong Duk Do Jae-Sung Rhee |
| author_sort | Jaehee Kim |
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| description | Short-chain chlorinated paraffins (SCCPs) are persistent organic pollutants of global concern. Despite their presence in low concentrations in aquatic environments, the detrimental effects of SCCPs on zooplankton remain limited. In this study, we evaluated the potential effects of acute and chronic exposure (24 h and 10 days) to various concentrations of SCCPs, including 1/10 NOEC, NOEC, and LC10, as retrieved from a 24-h toxicity experiment, using the monogonont rotifer Brachionus manjavacas. A dose-dependent increase in mortality was measured, with an LC50 value of 132 μg L−1 after 24 h. Treatment to the 24h-LC10 value significantly elevated intracellular content of reactive oxygen species, in addition with a marked elevation in malondialdehyde level. Glutathione levels were elevated following exposure to the 24-h LC10 value, along with the induction of enzymatic activities of crucial antioxidant components, including glutathione S-transferase, glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase. Chronic exposure to the NOEC value over 10 days resulted in hazardous effects on survival, lifespan, reproduction, and population maintenance in B. manjavacas. Taken together, SCCPs induced acute toxicity in rotifers primarily through the induction of oxidative stress. Even at sub-lethal concentrations, consistent exposure can lead to significant detrimental effects throughout the life cycle, indicating that SCCPs pose a serious threat to the sustainability of rotifer populations. |
| format | Article |
| id | doaj-art-e7c477e6cb4549cf9d609614fd0f1899 |
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| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
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| spelling | doaj-art-e7c477e6cb4549cf9d609614fd0f18992025-08-20T01:54:16ZengElsevierEcotoxicology and Environmental Safety0147-65132025-04-0129411808610.1016/j.ecoenv.2025.118086Acute and chronic effects of the short-chain chlorinated paraffins on the monogonont rotifer Brachionus manjavacas revealed by multi-biomarker determinationJaehee Kim0Seong Duk Do1Jae-Sung Rhee2Department of Marine Science, College of Natural Sciences, Incheon National University, Incheon 22012, Republic of KoreaDepartment of Marine Science, College of Natural Sciences, Incheon National University, Incheon 22012, Republic of KoreaDepartment of Marine Science, College of Natural Sciences, Incheon National University, Incheon 22012, Republic of Korea; Research Institute of Basic Sciences, Incheon National University, Incheon 22012, Republic of Korea; Yellow Sea Research Institute, Incheon 22012, Republic of Korea; Corresponding author at: Department of Marine Science, College of Natural Sciences, Incheon National University, Incheon 22012, Republic of Korea.Short-chain chlorinated paraffins (SCCPs) are persistent organic pollutants of global concern. Despite their presence in low concentrations in aquatic environments, the detrimental effects of SCCPs on zooplankton remain limited. In this study, we evaluated the potential effects of acute and chronic exposure (24 h and 10 days) to various concentrations of SCCPs, including 1/10 NOEC, NOEC, and LC10, as retrieved from a 24-h toxicity experiment, using the monogonont rotifer Brachionus manjavacas. A dose-dependent increase in mortality was measured, with an LC50 value of 132 μg L−1 after 24 h. Treatment to the 24h-LC10 value significantly elevated intracellular content of reactive oxygen species, in addition with a marked elevation in malondialdehyde level. Glutathione levels were elevated following exposure to the 24-h LC10 value, along with the induction of enzymatic activities of crucial antioxidant components, including glutathione S-transferase, glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase. Chronic exposure to the NOEC value over 10 days resulted in hazardous effects on survival, lifespan, reproduction, and population maintenance in B. manjavacas. Taken together, SCCPs induced acute toxicity in rotifers primarily through the induction of oxidative stress. Even at sub-lethal concentrations, consistent exposure can lead to significant detrimental effects throughout the life cycle, indicating that SCCPs pose a serious threat to the sustainability of rotifer populations.http://www.sciencedirect.com/science/article/pii/S0147651325004221Chlorinated paraffinsSCCPsMarine zooplanktonOxidative stressChronic toxicity |
| spellingShingle | Jaehee Kim Seong Duk Do Jae-Sung Rhee Acute and chronic effects of the short-chain chlorinated paraffins on the monogonont rotifer Brachionus manjavacas revealed by multi-biomarker determination Ecotoxicology and Environmental Safety Chlorinated paraffins SCCPs Marine zooplankton Oxidative stress Chronic toxicity |
| title | Acute and chronic effects of the short-chain chlorinated paraffins on the monogonont rotifer Brachionus manjavacas revealed by multi-biomarker determination |
| title_full | Acute and chronic effects of the short-chain chlorinated paraffins on the monogonont rotifer Brachionus manjavacas revealed by multi-biomarker determination |
| title_fullStr | Acute and chronic effects of the short-chain chlorinated paraffins on the monogonont rotifer Brachionus manjavacas revealed by multi-biomarker determination |
| title_full_unstemmed | Acute and chronic effects of the short-chain chlorinated paraffins on the monogonont rotifer Brachionus manjavacas revealed by multi-biomarker determination |
| title_short | Acute and chronic effects of the short-chain chlorinated paraffins on the monogonont rotifer Brachionus manjavacas revealed by multi-biomarker determination |
| title_sort | acute and chronic effects of the short chain chlorinated paraffins on the monogonont rotifer brachionus manjavacas revealed by multi biomarker determination |
| topic | Chlorinated paraffins SCCPs Marine zooplankton Oxidative stress Chronic toxicity |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325004221 |
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