Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide
A simple spectrophotometric method was developed for the determination of cefadroxil in pure bulk and in capsules forms. The method is based on a direct reaction between cefadroxil and sodium hydroxide (1 N). A product with λmax at 342 nm and molar absorptivity of 7.9x103 L mol-1 cm-1 is formed afte...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2011/568620 |
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| author | S. W. Shantier E. A. Gadkariem K. E. Ibrahim H. A. El-Obeid |
| author_facet | S. W. Shantier E. A. Gadkariem K. E. Ibrahim H. A. El-Obeid |
| author_sort | S. W. Shantier |
| collection | DOAJ |
| description | A simple spectrophotometric method was developed for the determination of cefadroxil in pure bulk and in capsules forms. The method is based on a direct reaction between cefadroxil and sodium hydroxide (1 N). A product with λmax at 342 nm and molar absorptivity of 7.9x103 L mol-1 cm-1 is formed after heating cefadroxil with sodium hydroxide (1 N) for 30 minutes. The absorbance-concentration plot was rectilinear over the range 5-25 μg/mL with correlation coefficient values not less than 0.999. The detection limit (LOD) and quantification limit (LOQ) were 0.693 μg/mL and 2.31 μg/mL. The method was validated using the BP liquid chromatographic method for cefadroxil assay. The results obtained by the developed method for the capsules dosage form were statistically compared with those of the BP liquid chromatography method and evaluated at 95% confidence limits. |
| format | Article |
| id | doaj-art-e7bfa350d51345a88506ce94af20aa03 |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-e7bfa350d51345a88506ce94af20aa032025-02-03T01:12:37ZengWileyE-Journal of Chemistry0973-49452090-98102011-01-01831314132210.1155/2011/568620Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium HydroxideS. W. Shantier0E. A. Gadkariem1K. E. Ibrahim2H. A. El-Obeid3Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, SudanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, SudanDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Khartoum, SudanDepartment of Pharmaceutical Chemistry, University of Medical Sciences and Technology, SudanA simple spectrophotometric method was developed for the determination of cefadroxil in pure bulk and in capsules forms. The method is based on a direct reaction between cefadroxil and sodium hydroxide (1 N). A product with λmax at 342 nm and molar absorptivity of 7.9x103 L mol-1 cm-1 is formed after heating cefadroxil with sodium hydroxide (1 N) for 30 minutes. The absorbance-concentration plot was rectilinear over the range 5-25 μg/mL with correlation coefficient values not less than 0.999. The detection limit (LOD) and quantification limit (LOQ) were 0.693 μg/mL and 2.31 μg/mL. The method was validated using the BP liquid chromatographic method for cefadroxil assay. The results obtained by the developed method for the capsules dosage form were statistically compared with those of the BP liquid chromatography method and evaluated at 95% confidence limits.http://dx.doi.org/10.1155/2011/568620 |
| spellingShingle | S. W. Shantier E. A. Gadkariem K. E. Ibrahim H. A. El-Obeid Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide E-Journal of Chemistry |
| title | Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide |
| title_full | Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide |
| title_fullStr | Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide |
| title_full_unstemmed | Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide |
| title_short | Spectrophotmetric Determination of Cefadroxil in Bulk and Dosage Form Using Sodium Hydroxide |
| title_sort | spectrophotmetric determination of cefadroxil in bulk and dosage form using sodium hydroxide |
| url | http://dx.doi.org/10.1155/2011/568620 |
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